Search Results - "OHIZUMI, Iwao"

Anti-glypican 3 antibody as a potential antitumor agent for human liver cancer by Ishiguro, Takahiro, Sugimoto, Masamichi, Kinoshita, Yasuko, Miyazaki, Yoko, Nakano, Kiyotaka, Tsunoda, Hiroyuki, Sugo, Izumi, Ohizumi, Iwao, Aburatani, Hiroyuki, Hamakubo, Takao, Kodama, Tatsuhiko, Tsuchiya, Masayuki, Yamada-Okabe, Hisafumi

“…Human glypican 3 (GPC3) is preferentially expressed in the tumor tissues of liver cancer patients. In this study, we obtained a monoclonal antibody (mAb)…”
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A new disulfide‐linked dimer of a single‐chain antibody fragment against human CD47 induces apoptosis in lymphoid malignant cells via the hypoxia inducible factor‐1α pathway by Sagawa, Morihiko, Shimizu, Takatsune, Fukushima, Naoshi, Kinoshita, Yasuko, Ohizumi, Iwao, Uno, Shinsuke, Kikuchi, Yasufumi, Ikeda, Yasuo, Yamada‐Okabe, Hisafumi, Kizaki, Masahiro

“…CD47 belongs to the immunoglobulin superfamily and is associated with β‐integrins. Recently it was reported that CD47 ligation rapidly induces apoptosis in…”
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Identification of soluble NH2-terminal fragment of glypican-3 as a serological marker for early-stage hepatocellular carcinoma by HIPPO, Yoshitaka, WATANABE, Kiyotaka, NEZU, Jun-Ichi, TSUNODA, Hiroyuki, YOSHINO, Takeshi, OHIZUMI, Iwao, TSUCHIYA, Masayuki, OHNISHI, Shin, MAKUUCHI, Masatoshi, HAMAKUBO, Takao, KODAMA, Tatsuhiko, ABURATANI, Hiroyuki, WATANABE, Akira, MIDORIKAWA, Yutaka, YAMAMOTO, Shogo, IHARA, Sigeo, TOKITA, Susumu, IWANARI, Hiroko, ITO, Yukio, NAKANO, Kiyotaka

“…For detection of hepatocellular carcinoma (HCC) in patients with liver cirrhosis, serum alpha-fetoprotein has been widely used, but its sensitivity has not…”
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Viral envelope protein gp64 transgenic mouse facilitates the generation of monoclonal antibodies against exogenous membrane proteins displayed on baculovirus by Saitoh, Ryoichi, Ohtomo, Toshihiko, Yamada, Yoshiki, Kamada, Nobuo, Nezu, Jun-ichi, Kimura, Naoki, Funahashi, Shin-ichi, Furugaki, Koh, Yoshino, Takeshi, Kawase, Yosuke, Kato, Atsuhiko, Ueda, Otoya, Jishage, Kou-ichi, Suzuki, Masami, Fukuda, Rie, Arai, Masahiro, Iwanari, Hiroko, Takahashi, Kazuaki, Sakihama, Toshiko, Ohizumi, Iwao, Kodama, Tatsuhiko, Tsuchiya, Masayuki, Hamakubo, Takao

“…We have been investigating the functional display of multipass membrane protein such as transporter or G-protein coupled receptor on the budded baculovirus…”
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Discovery of thiochroman derivatives bearing a carboxy-containing side chain as orally active pure antiestrogens by Kanbe, Yoshitake, Kim, Myung-Hwa, Nishimoto, Masahiro, Ohtake, Yoshihito, Tsunenari, Toshiaki, Taniguchi, Kenji, Ohizumi, Iwao, Kaiho, Shin-ichi, Nabuchi, Yoshiaki, Kawata, Setsu, Morikawa, Kazumi, Jo, Jae-Chon, Kwon, Hee-An, Lim, Hyun-Suk, Kim, Hak-Yeop

“…Thiochroman derivatives bearing the carboxy moiety in the long side chain exhibited remarkable antiestrogen activity when administered orally. In order to…”
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Recovery of functional peptide transporter PepT1 in budded baculovirus fraction by Saitoh, Ryoichi, Ohtomo, Toshihiko, Ito, Yukio, Nezu, Jun-ichi, Kimura, Naoki, Funahashi, Shin-ichi, Aso, Yoshinori, Ohizumi, Iwao, Kodama, Tatsuhiko, Hamakubo, Takao, Tsuchiya, Masayuki

“…Transporters play a critical role in many physiological and pathological states and expression of the functional transporter protein is essential in exploring…”
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Molecular cloning and characterization of antigens expressed on rat tumor vascular endothelial cells by Taniguchi, Kenji, Harada, Naoki, Ohizumi, Iwao, Kinoshita, Michiko, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Kaiho, Shin‐ichi, Mayumi, Tadanori

“…We have previously prepared monoclonal antibodies (MAbs) against tumor vasculature using cultured rat tumor endothelial cells (TECs) isolated from solid KMT‐17…”
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Recognition of Human Activated CD44 by Tumor Vasculature-Targeted Antibody by Taniguchi, Kenji, Harada, Naoki, Ohizumi, Iwao, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Kaiho, Shin-ichi, Mayumi, Tadanori

“…TES-23 monoclonal antibody (MAb), which targets rat CD44H on tumor vascular endothelial cells (TEC), dominantly reacted to human activated CD44 rather than…”
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Tumor Vascular Targeting Using a Tumor-Tissue Endothelium-Specific Monoclonal Antibody as an Effective Strategy for Cancer Chemotherapy by Makimoto, Hiroo, Koizumi, Kei-ichi, Tsunoda, Shin-ichi, Wakai, Yukiko, Matsui, Junji, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Ohizumi, Iwao, Taniguchi, Kenji, Saito, Hiroyuki, Utoguchi, Naoki, Ohsugi, Yoshiyuki, Mayumi, Tadanori

“…In this study, we attempted to develop tumor vascular targeting with a tumor tissue endothelium-specific monoclonal antibody. TES-23, which strongly and…”
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Suppression of solid tumor growth by a monoclonal antibody against tumor vasculature in rats: Involvement of intravascular thrombosis and fibrinogenesis by Ohizumi, Iwao, Taniguchi, Kenji, Saito, Hiroyuki, Kawata, Hiromitsu, Tsunoda, Shin‐ichi, Makimoto, Hiroo, Wakai, Yukiko, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Utoguchi, Naoki, Kaiho, Shin‐ichi, Ohsugi, Yoshiyuki, Mayumi, Tadanori

“…We have reported that immunization of rat tumor‐derived endothelial cells (TEC) isolated from KMT‐17 solid tumors results in the generation of several…”
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Identification of tumor vascular antigens by monoclonal antibodies prepared from rat‐tumor‐derived endothelial cells by Ohizumi, Iwao, Tsunoda, Shin‐ichi, Taniguchi, Kenji, Saito, Hiroyuki, Esaki, Keiko, Koizumi, Keiichi, Makimoto, Hiroo, Wakai, Yukiko, Matsui, Junji, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Utoguchi, Naoki, Ohsugi, Yoshiyuki, Mayumi, Tadanori

“…We have reported the isolation and specific in vitro properties of tumor‐derived endothelial cells (TEC) from rat KMT‐17 fibrosarcomas transplanted into rats…”
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Effective Cancer Targeting Using an Anti‐tumor Tissue Vascular Endotheliumspecific Monoclonal Antibody (TES‐23) by Wakai, Yukiko, Matsui, Junji, Koizumi, Keiichi, Tsunoda, Shin‐ichi, Makimoto, Hiroo, Ohizumi, Iwao, Taniguchi, Kenji, Kaiho, Shin‐ichi, Saito, Hiroyuki, Utoguchi, Naoki, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Ohsugi, Yoshiyuki, Mayumi, Tadanori

“…Immunoconjugate targeting of solid tumors has not been routinely successful because the endothelial cells of blood vessels act as a physical barrier against…”
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Anti-glypican 3 antibodies cause ADCC against human hepatocellular carcinoma cells by Nakano, Kiyotaka, Orita, Tetsuro, Nezu, Junichi, Yoshino, Takeshi, Ohizumi, Iwao, Sugimoto, Masamichi, Furugaki, Koh, Kinoshita, Yasuko, Ishiguro, Takahiro, Hamakubo, Takao, Kodama, Tatsuhiko, Aburatani, Hiroyuki, Yamada-Okabe, Hisafumi, Tsuchiya, Masayuki

“…Glypican 3 (GPC3), a GPI-anchored heparan sulfate proteoglycan, is expressed in the majority of hepatocellular carcinoma (HCC) tissues. Using MRL/lpr mice, we…”
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Antibody-Based Therapy Targeting Tumor Vascular Endothelial Cells Suppresses Solid Tumor Growth in Rats by Ohizumi, Iwao, Tsunoda, Shin-ichi, Taniguchi, Kenji, Saito, Hiroyuki, Esaki, Keiko, Makimoto, Hiroo, Wakai, Yukiko, Tsutsumi, Yasuo, Nakagawa, Shinsaku, Utoguchi, Naoki, Kaiho, Shin-ichi, Ohsugi, Yoshiyuki, Mayumi, Tadanori

“…We have developed a new approach to antibody-based therapy of solid tumors by targeting tumor vascular endothelial cells (EC) which are essential for the…”
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Thiochroman Derivative CH4986399, A New Nonsteroidal Estrogen Receptor Down-regulator, Is Effective in Breast Cancer Models by YONEYA, Takaaki, TANIGUCHI, Kenji, NAKAMURA, Ryo, TSUNENARI, Toshiaki, OHIZUMI, Iwao, KANBE, Yoshitake, MORIKAWA, Kazumi, KAIHO, Shin-Ichi, YAMADA-OKABE, Hisafumi

“…Tamoxifen, a selective estrogen receptor modulator, and fulvestrant, a selective estrogen receptor down-regulator (SERD), are now available for estrogen…”
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Abstract 2426: Anti-Glypican3 antibody for treatment of human liver cancer by Ishiguro, Takahiro, Kinoshita, Yasuko, Sugimoto, Masamichi, Miyazaki, Yoko, Kato, Atsuhiko, Nakano, Kiyotaka, Takai, Hirotake, Tsunoda, Hiroyuki, Sugo, Izumi, Ohizumi, Iwao, Aburatani, Hiroyuki, Hamakubo, Takao, Kodama, Tatsuhiko, Tsuchiya, Masayuki, Okabe, Hisafumi Yamada

“…Abstract Glypican-3 (GPC3) is a member of the glypican family of heparan sulfate proteoglycans, which are linked to the cell surface through a glycosyl…”
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A New Disulfide-Linked Dimer of a Single-Chain Antibody Fragment Against Human CD47 Induces Apoptosis in Lymphoid Malignant Cells In Vitro and In Vivo Via the HIF-1α Pathway: A Possible Novel Therapeutic Agent for B-CLL by Sagawa, Morihiko, Shimizu, Takatsune, Xian, Mingji, Chizuka, Aki, Fukushima, Naoshi, Kinoshita, Yasuko, Ohizumi, Iwao, Ikeda, Yasuo, Okabe, Hisafumi, Kizaki, Masahiro

“…CD47 belongs to the immunoglobulin superfamily, and is expressed as a 50 kDa cell surface antigen in a wide variety of tissues. CD47 is associated with…”
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Discovery of thiochroman and chroman derivatives as pure antiestrogens and their structure–activity relationship by Kanbe, Yoshitake, Kim, Myung-Hwa, Nishimoto, Masahiro, Ohtake, Yoshihito, Kato, Nobuaki, Tsunenari, Toshiaki, Taniguchi, Kenji, Ohizumi, Iwao, Kaiho, Shin-ichi, Morikawa, Kazumi, Jo, Jae-Chon, Lim, Hyun-Suk, Kim, Hak-Yeop

“…In order to develop pure antiestrogens, a series of 7-hydroxy-3-(4-hydroxyphenyl)chroman and 7-hydroxy-3-(4-hydroxyphenyl)thiochroman derivatives with…”
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Newly discovered orally active pure antiestrogens by Kanbe, Yoshitake, Kim, Myung-Hwa, Nishimoto, Masahiro, Ohtake, Yoshihito, Yoneya, Takaaki, Ohizumi, Iwao, Tsunenari, Toshiaki, Taniguchi, Kenji, Kaiho, Shin-ichi, Nabuchi, Yoshiaki, Araya, Hiroshi, Kawata, Setsu, Morikawa, Kazumi, Jo, Jae-Chon, Kwon, Hee-An, Lim, Hyun-Suk, Kim, Hak-Yeop

“…Steroid derivatives bearing the carboxy moiety in the long side chain at the 7-α position exhibited remarkable antiestrogen activities when administered…”
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Effective cancer targeting using an anti-tumor tissue vascular endothelium-specific monoclonal antibody (TES23) by WAKAI, Yukiko, MATSUI, Junji, TSUTSUMI, Yasuo, NAKAGAWA, Shinsaku, OHSUGI, Yoshiyuki, MAYUMI, Tadanori, KOIZUMI, Keiichi, TSUNODA, Shin-Ichi, MAKIMOTO, Hiroo, OHIZUMI, Iwao, TANIGUCHI, Kenji, KAIHO, Shin-Ihi, SAITO, Hiroyuki, UTOGUCHI, Naoki

“…Immunoconjugate targeting of solid tumors has not been routinely successful because the endo-thelial cells of blood vessels act as a physical barrier against…”
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