Search Results - "OHBA, Shinsuke"

Hedgehog Signaling in Skeletal Development: Roles of Indian Hedgehog and the Mode of Its Action by Ohba, Shinsuke

“…Hedgehog (Hh) signaling is highly conserved among species and plays indispensable roles in various developmental processes. There are three Hh members in…”
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Hedgehog Signaling in Endochondral Ossification by Ohba, Shinsuke

“…Hedgehog (Hh) signaling plays crucial roles in the patterning and morphogenesis of various organs within the bodies of vertebrates and insects. Endochondral…”
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Genome-scale actions of master regulators directing skeletal development by Ohba, Shinsuke

“…The mammalian skeleton develops through two distinct modes of ossification: intramembranous ossification and endochondral ossification. During the process of…”
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Understanding paraxial mesoderm development and sclerotome specification for skeletal repair by Tani, Shoichiro, Chung, Ung-il, Ohba, Shinsuke, Hojo, Hironori

“…Pluripotent stem cells (PSCs) are attractive regenerative therapy tools for skeletal tissues. However, a deep understanding of skeletal development is required…”
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Sp7 Action in the Skeleton: Its Mode of Action, Functions, and Relevance to Skeletal Diseases by Hojo, Hironori, Ohba, Shinsuke

“…Osteoblast differentiation is a tightly regulated process in which key transcription factors (TFs) and their target genes constitute gene regulatory networks…”
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Kruppel-like Factors in Skeletal Physiology and Pathologies by Abe, Makoto, Saeki, Naoya, Ikeda, Yuki, Ohba, Shinsuke

“…Kruppel-like factors (KLFs) belong to a large group of zinc finger-containing transcription factors with amino acid sequences resembling the Drosophila gap…”
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Single-Cell RNA-Sequencing Reveals the Skeletal Cellular Dynamics in Bone Repair and Osteoporosis by Wu, Sixun, Ohba, Shinsuke, Matsushita, Yuki

“…The bone is an important organ that performs various functions, and the bone marrow inside the skeleton is composed of a complex intermix of hematopoietic,…”
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Distinct Transcriptional Programs Underlie Sox9 Regulation of the Mammalian Chondrocyte by Ohba, Shinsuke, He, Xinjun, Hojo, Hironori, McMahon, Andrew P.

“…Sox9 encodes an essential transcriptional regulator of chondrocyte specification and differentiation. When Sox9 nuclear activity was compared with markers of…”
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Runx1 contributes to articular cartilage maintenance by enhancement of cartilage matrix production and suppression of hypertrophic differentiation by Yano, Fumiko, Ohba, Shinsuke, Murahashi, Yasutaka, Tanaka, Sakae, Saito, Taku, Chung, Ung-il

“…Osteoarthritis (OA) results from an imbalance of the dynamic equilibrium between the breakdown and repair of joint tissues. Previously, we reported that Runx1…”
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Generation of orthotopically functional salivary gland from embryonic stem cells by Tanaka, Junichi, Ogawa, Miho, Hojo, Hironori, Kawashima, Yusuke, Mabuchi, Yo, Hata, Kenji, Nakamura, Shiro, Yasuhara, Rika, Takamatsu, Koki, Irié, Tarou, Fukada, Toshiyuki, Sakai, Takayoshi, Inoue, Tomio, Nishimura, Riko, Ohara, Osamu, Saito, Ichiro, Ohba, Shinsuke, Tsuji, Takashi, Mishima, Kenji

“…Organoids generated from pluripotent stem cells are used in the development of organ replacement regenerative therapy by recapitulating the process of…”
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Direct cell–cell contact between mature osteoblasts and osteoclasts dynamically controls their functions in vivo by Furuya, Masayuki, Kikuta, Junichi, Fujimori, Sayumi, Seno, Shigeto, Maeda, Hiroki, Shirazaki, Mai, Uenaka, Maki, Mizuno, Hiroki, Iwamoto, Yoriko, Morimoto, Akito, Hashimoto, Kunihiko, Ito, Takeshi, Isogai, Yukihiro, Kashii, Masafumi, Kaito, Takashi, Ohba, Shinsuke, Chung, Ung-il, Lichtler, Alexander C., Kikuchi, Kazuya, Matsuda, Hideo, Yoshikawa, Hideki, Ishii, Masaru

“…Bone homeostasis is regulated by communication between bone-forming mature osteoblasts (mOBs) and bone-resorptive mature osteoclasts (mOCs). However, the…”
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ChIP-Seq Assays from Mammalian Cartilage and Chondrocytes by Yamakawa, Akira, Hojo, Hironori, Ohba, Shinsuke

“…Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is a powerful tool to identify binding profiles of transcriptional regulators and chromatin…”
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Mesenchymal stromal cells in the bone marrow niche consist of multi-populations with distinct transcriptional and epigenetic properties by Kanazawa, Sanshiro, Okada, Hiroyuki, Hojo, Hironori, Ohba, Shinsuke, Iwata, Junichi, Komura, Makoto, Hikita, Atsuhiko, Hoshi, Kazuto

“…Although multiple studies have investigated the mesenchymal stem and progenitor cells (MSCs) that give rise to mature bone marrow, high heterogeneity in their…”
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Periosteal stem cells control growth plate stem cells during postnatal skeletal growth by Tsukasaki, Masayuki, Komatsu, Noriko, Negishi-Koga, Takako, Huynh, Nam Cong-Nhat, Muro, Ryunosuke, Ando, Yutaro, Seki, Yuka, Terashima, Asuka, Pluemsakunthai, Warunee, Nitta, Takeshi, Nakamura, Takashi, Nakashima, Tomoki, Ohba, Shinsuke, Akiyama, Haruhiko, Okamoto, Kazuo, Baron, Roland, Takayanagi, Hiroshi

“…The ontogeny and fate of stem cells have been extensively investigated by lineage-tracing approaches. At distinct anatomical sites, bone tissue harbors…”
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Fabrication of calcium phosphate-loaded carboxymethyl cellulose non-woven sheets for bone regeneration by Qi, Pan, Ohba, Shinsuke, Hara, Yuichi, Fuke, Masaya, Ogawa, Takayuki, Ohta, Seiichi, Ito, Taichi

“…[Display omitted] •Calcium phosphate-loaded carboxymethyl cellulose non-woven sheets (CMC/CaP sheet) were fabricated.•The combined effect of CMC and CaP…”
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Switching of Cell Proliferation/Differentiation in Thiol–Maleimide Clickable Microcapsules Triggered by in Situ Conjugation of Biomimetic Peptides by Oki, Yuichiro, Kirita, Katsuhisa, Ohta, Seiichi, Ohba, Shinsuke, Horiguchi, Ikki, Sakai, Yasuyuki, Ito, Taichi

“…Extracellular environments significantly affect cell proliferation, differentiation, and functions. The extracellular environment changes during many…”
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Runx2 and Runx3 differentially regulate articular chondrocytes during surgically induced osteoarthritis development by Nagata, Kosei, Hojo, Hironori, Chang, Song Ho, Okada, Hiroyuki, Yano, Fumiko, Chijimatsu, Ryota, Omata, Yasunori, Mori, Daisuke, Makii, Yuma, Kawata, Manabu, Kaneko, Taizo, Iwanaga, Yasuhide, Nakamoto, Hideki, Maenohara, Yuji, Tachibana, Naohiro, Ishikura, Hisatoshi, Higuchi, Junya, Taniguchi, Yuki, Ohba, Shinsuke, Chung, Ung-il, Tanaka, Sakae, Saito, Taku

“…The Runt-related transcription factor (Runx) family plays various roles in the homeostasis of cartilage. Here, we examined the role of Runx2 and Runx3 for…”
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Bone regeneration by human dental pulp stem cells using a helioxanthin derivative and cell-sheet technology by Fujii, Yasuyuki, Kawase-Koga, Yoko, Hojo, Hironori, Yano, Fumiko, Sato, Marika, Chung, Ung-Il, Ohba, Shinsuke, Chikazu, Daichi

“…Human dental pulp stem cells (DPSCs), which have the ability to differentiate into multiple lineages, were recently identified. DPSCs can be collected readily…”
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Wnt/β-catenin signaling contributes to articular cartilage homeostasis through lubricin induction in the superficial zone by Xuan, Fengjun, Yano, Fumiko, Mori, Daisuke, Chijimatsu, Ryota, Maenohara, Yuji, Nakamoto, Hideki, Mori, Yoshifumi, Makii, Yuma, Oichi, Takeshi, Taketo, Makoto Mark, Hojo, Hironori, Ohba, Shinsuke, Chung, Ung-Il, Tanaka, Sakae, Saito, Taku

“…Both loss- and gain-of-function of Wnt/β-catenin signaling in chondrocytes result in exacerbation of osteoarthritis (OA). Here, we examined the activity and…”
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Messenger RNA delivery of a cartilage-anabolic transcription factor as a disease-modifying strategy for osteoarthritis treatment by Aini, Hailati, Itaka, Keiji, Fujisawa, Ayano, Uchida, Hirokuni, Uchida, Satoshi, Fukushima, Shigeto, Kataoka, Kazunori, Saito, Taku, Chung, Ung-il, Ohba, Shinsuke

“…Osteoarthritis (OA) is a chronic degenerative joint disease and a major health problem in the elderly population. No disease-modifying osteoarthritis drug…”
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