CLINICAL EXPERIENCE OF CS-1170 IN URINARY TRACT INFECTIONS

1. CS-1170 was administered to 56 in-patients diagnosed as urinary tract infection at each Department of Urology of Kyushu University, Fukuoka University, Sanshin-Kai Hara Hospital, Kyushu Kosei Nenkin Hospital, Miyazaki Prefectural Hospital and Hiroshima Red Cross Hospital from February to July 197...

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Published in:	CHEMOTHERAPY Vol. 26; no. Supplement5; pp. 526 - 536
Main Authors:	MOMOSE, SHUNRO, KUMAZAWA, JOICHI, SAKAMOTO, KIMITAKA, ARIYOSHI, ASAMI, OSHIMA, KAZUHIRO, HARA, SANSHIN, HARA, TAKAHIKO, NANRI, KAZUSHIGE, YAMAGUCHI, AKITO, OMOTO, TETSUO, TAKESUE, TETSURO, ITO, KENJI, KURODA, NORIYUKI, NAKAYAMA, KEN, HIEDA, SADAMU, HIRATA, HIROSHI, OGUSU, MASATO, KURAMOTO, HIROSHI
Format:	Journal Article
Language:	English Japanese
Published:	Japanese Society of Chemotherapy 1978
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Summary:	1. CS-1170 was administered to 56 in-patients diagnosed as urinary tract infection at each Department of Urology of Kyushu University, Fukuoka University, Sanshin-Kai Hara Hospital, Kyushu Kosei Nenkin Hospital, Miyazaki Prefectural Hospital and Hiroshima Red Cross Hospital from February to July 1977. 2. Cases were selected at random, and CS-1170 was administered intravenously to 28 cases at a dose of 0.5 g twice daily (morning and evening), and the drug was administered intravenously to 28 cases at a dose of 1.0g twice daily (morning and evening), each consecutively for 5 days. 3. Six cases were dropouted following the judgement of doctors in charge, and the results obtained were excellent in 19 cases, good in 20 cases and poor in 11 cases, that is, excellent rate 38%, and effective rate 78%. The group of lg daily resulted in excellent 7 cases, good 10 cases, poor 6 cases, excellent rate 30.4% and effective rate 73.9%, whereas the group of 2g daily resulted in excellent 12 cases, good 10 cases, poor 5 cases, excellent rate 44.4% and effective rate 81.5%, no significant difference being observed thus between both groups. 4. Thirty-five cases of chronic complicated urinary tract infection were judged the results following Judgement by UT! Criteria, and the results obtained were excellent in 3 cases, good in 19 cases, poor in 12 cases, and effective rate 64.8%. The group of 1 g daily resulted in excellent 2 cases, good 11 cases, poor 6 cases, and effective rate 68.4%3, whereas the group of 2 g daily resulted in excellent 1 case, good 8 cases, poor 6 cases, and effective rate 60%, no significant difference being observed thus between both groups. 5. No side effect of the drug was noticed, except a case complained of nausea, vomiting and anxiety, and the administration was interrupted after 2 days. 6. Bacteriologically, 32 strains out of 55 strains disappeared, 7 strains persisted, and 11 strains were substituted. All 4 strains of E. coli disappeared, while 12 strains out of 17 strains of Proteus sp. and 10 strains out of 11 strains of Serratia disappeared. Out of 6 strains of Pseudomonas sp., 1 strain disappeared and other 5 strains persisted. Pseudomonas sp. was found in 5 strains out of 12 strains which appeared as bacterial substitution.
ISSN:	0009-3165 1884-5894
DOI:	10.11250/chemotherapy1953.26.Supplement5_526