Search Results - "OGURI, Kazuta"

Interaction of cytochrome P450 3A4 and UDP-glucuronosyltransferase 2B7: evidence for protein-protein association and possible involvement of CYP3A4 J-helix in the interaction by Takeda, Shuso, Ishii, Yuji, Iwanaga, Megumi, Nurrochmad, Arief, Ito, Yuji, Mackenzie, Peter I, Nagata, Kiyoshi, Yamazoe, Yasushi, Oguri, Kazuta, Yamada, Hideyuki

“…We have reported that the protein-protein interaction between UDP-glucuronosyltransferase (UGT) 2B7 and cytochrome P450 3A4 (CYP3A4) alters UGT2B7 function…”
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INHIBITION OF UDP-GLUCURONOSYLTRANSFERASE 2B7-CATALYZED MORPHINE GLUCURONIDATION BY KETOCONAZOLE: DUAL MECHANISMS INVOLVING A NOVEL NONCOMPETITIVE MODE by TAKEDA, Shuso, KITAJIMA, Yurie, ISHII, Yuji, NISHIMURA, Yoshio, MACKENZIE, Peter I, OGURI, Kazuta, YAMADA, Hideyuki

“…Glucuronidation of morphine in humans is predominantly catalyzed by UDP-glucuronosyltransferase 2B7 (UGT2B7). Since our recent research suggested that…”
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Induction of the hepatic cytochrome P450 2B subfamily by xenobiotics: research history, evolutionary aspect, relation to tumorigenesis, and mechanism by Yamada, Hideyuki, Ishii, Yuji, Yamamoto, Midori, Oguri, Kazuta

“…The cytochrome P450 belonging to the CYP2B subfamily has long been of great interest because it can be induced by xenobiotics. While a well known diagnostic…”
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Modulation of UDP-glucuronosyltransferase function by cytochrome P450: evidence for the alteration of UGT2B7-catalyzed glucuronidation of morphine by CYP3A4 by Takeda, Shuso, Ishii, Yuji, Iwanaga, Megumi, Mackenzie, Peter I, Nagata, Kiyoshi, Yamazoe, Yasushi, Oguri, Kazuta, Yamada, Hideyuki

“…Modulation of UDP-glucuronosyltransferase 2B7 (UGT2B7)-catalyzed morphine glucuronidation by cytochrome P450 (P450) was studied. The effects of P450 isozymes…”
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Suppression of Carbonic Anhydrase III mRNA Level by an Aryl Hydrocarbon Receptor Ligand in Primary Cultured Hepatocytes of Rat by Ishii, Yuji, Akazawa, Daisuke, Aoki, Yasunobu, Yamada, Hideyuki, Oguri, Kazuta

“…The effect of an aryl hydrocarbon receptor (AhR) ligand on the carbonic anhydrase III (CAIII) mRNA level was studied using primary cultured hepatocytes of…”
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Cytochrome P450 1A1 (CYP1A1) Inhibitor α-Naphthoflavone Interferes with UDP-Glucuronosyltransferase (UGT) Activity in Intact but Not in Permeabilized Hepatic Microsomes from 3-Methylcholanthrene-Treated Rats: Possible Involvement of UGT–P450 Interactions by Taura, Ken-ichiro, Naito, Eri, Ishii, Yuji, Mori, Masa-aki, Oguri, Kazuta, Yamada, Hideyuki

“…The effects of cytochrome P450 (P450, CYP) ligands and permeabilization of microsomes on 3-hydroxybenzo(a)pyrene [3-OH-B(a)P] glucuronidation mediated by rat…”
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Simultaneous expression of guinea pig UDP-glucuronosyltransferase 2B21 and 2B22 in COS-7 cells enhances UDP-glucuronosyltransferase 2B21-catalyzed morphine-6-glucuronide formation by Ishii, Y, Miyoshi, A, Watanabe, R, Tsuruda, K, Tsuda, M, Yamaguchi-Nagamatsu, Y, Yoshisue, K, Tanaka, M, Maji, D, Ohgiya, S, Oguri, K

“…Although UDP-glucuronosyltransferases (UGTs) act as an important detoxification system for many endogenous and exogenous compounds, they are also involved in…”
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Reduction of the Toxicity of 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Mice Using an Antiulcer Drug, Geranylgeranylacetone by Ishida, Takumi, Oshimo, Tomomi, Nishimura, Akihisa, Mutoh, Junpei, Ishii, Yuji, Koga, Nobuyuki, Yamada, Hideyuki, Hashiguchi, Isao, Akamine, Akifumi, Oguri, Kazuta

“…The protective effect of geranylgeranylacetone (GGA), an antiulcer drug, against the acute toxicity and teratogenicity produced by…”
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Modulation of UDP-Glucuronosyltransferase 2B7 Function by Cytochrome P450s in Vitro: Differential Effects of CYP1A2, CYP2C9 and CYP3A4 by Takeda, Shuso, Ishii, Yuji, Mackenzie, Peter I., Nagata, Kiyoshi, Yamazoe, Yasushi, Oguri, Kazuta, Yamada, Hideyuki

“…Effects of cytochrome P450 isoforms, CYP1A2, CYP2C9 and CYP3A4, on the catalytic activity of UDP-glucuronosyltransferase 2B7 (UGT2B7) expressed in COS cell…”
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Characteristic glucuronidation pattern of physiologic concentration of morphine in rat brain by Nagano, Emiko, Yamada, Hideyuki, Oguri, Kazuta

“…Formation of conjugated metabolites from morphine at a very low level in brain was studied in vitro in rats. Incubation of a low concentration of 3H-morphine…”
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A Highly Toxic Coplanar Polychlorinated Biphenyl Compound Suppresses Δ5 and Δ6 Desaturase Activities Which Play Key Roles in Arachidonic Acid Synthesis in Rat Liver by Matsusue, Kimihiko, Ishii, Yuji, Ariyoshi, Noritaka, Oguri, Kazuta

“…The effect of 3,3‘,4,4‘,5-pentachlorobiphenyl (PenCB) on the synthesis of unsaturated fatty acids was studied in male Wistar rats. The arachidonic acid (20:4)…”
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Estrogen-Dependent Regulation of the Expression of Hepatic Cyp2b and 3a Isoforms: Assessment Using Aromatase-Deficient Mice by Yamada, Hideyuki, Gohyama, Noriko, Honda, Shin-ichiro, Hara, Takayuki, Harada, Nobuhiro, Oguri, Kazuta

“…The role of estrogen in the expression and induction of hepatic Cyp2b and Cyp3a isoforms was studied using mice [Ar (−/−) mice] lacking aromatase, a key enzyme…”
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Effects of dioxins on stress-responsive systems and their relevance to toxicity by Ishida, Takumi, Hori, Miho, Ishii, Yuji, Oguri, Kazuta, Yamada, Hideyuki

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Enhancement of Acetaminophen Cytotoxicity in Selenium-binding Protein-overexpressed COS-1 Cells by Ishida, Takumi, Abe, Masamiki, Oguri, Kazuta, Yamada, Hideyuki

“…The role of selenium-binding protein (SeBP), which has a high ability to associate with acetaminophen (AAP), on the cytotoxicity of AAP was studied. To clarify…”
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Metabolism of Drugs of Abuse: Its Contribution to the Toxicity and the Inter-Individual Differences in Drug Sensitivity by Yamada, Hideyuki, Ishii, Yuji, Oguri, Kazuta

“…Abuse of drugs remains a serious and world-wide problem. As exemplified by opioids, there are large inter-individual differences in the effects and toxicity of…”
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FORMATION OF HIGHLY ANALGESIC MORPHINE-6-GLUCURONIDE FOLLOWING PHYSIOLOGIC CONCENTRATION OF MORPHINE IN HUMAN BRAIN by YAMADA, Hideyuki, ISHII, Kumiko, ISHII, Yuji, IEIRI, Ichiro, NISHIO, Syunji, MORIOKA, Takato, OGURI, Kazuta

“…3H-Morphine at physiologic concentration was metabolized in vitro to its 3- and 6-glucuronides by human brain homogenate. Recombinant UGT2B7, one of the…”
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Liver Proteins that are Sensitive to a Dioxin-Like Toxic Compound, Coplanar Polychlorinated Biphenyl, 3,3′,4,4′,5-Pentachlorobiphenyl by Ishii, Yuji, Oguri, Kazuta

“…This review deals with the reducing ability of a dioxin-like toxic compound, coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PCB126) in…”
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A highly toxic PCB produces unusual changes in the fatty acid composition of rat liver by Matsusue, Kimihiko, Ishii, Yuji, Ariyoshi, Noritaka, Oguri, Kazuta

“…The changes in lipici metabolism produced by a coplanar PCB were studied in rats. Male Wistar rats were given a single intraperitoneal injection of…”
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Effect of a Ligand Selective for Peripheral Benzodiazepine Receptors on the Expression of Rat Hepatic P-450 Cytochromes: Assessment of the Effect In Vivo and in a Hepatocyte Culture System by YAMADA, H, MATSUKI, Y, YAMAGUCHI, T, OGURI, K

“…The peripheral benzodiazepine receptor plays a role in the translocation of cholesterol into mitochondria where steroidogenesis occurs. Sterols have been…”
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Suppression of Carbonic Anhydrase III in Rat Liver by a Dioxin-Related Toxic Compound, Coplanar Polychlorinated Biphenyl, 3,3′,4,4′,5-Pentachlorobiphenyl by Ikeda, Masumi, Ishii, Yuji, Kato, Harutoshi, Akazawa, Daisuke, Hatsumura, Megumu, Ishida, Takumi, Matsusue, Kimihiko, Yamada, Hideyuki, Oguri, Kazuta

“…A coplanar polychlorinated biphenyl, 3,3′,4,4′,5-pentachlorobiphenyl (PenCB), significantly suppresses the expression of rat liver carbonic anhydrase III…”
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