Search Results - "OGURA, Keiji"

Construction of an integrated database for hERG blocking small molecules by Sato, Tomohiro, Yuki, Hitomi, Ogura, Keiji, Honma, Teruki

“…The inhibition of the hERG potassium channel is closely related to the prolonged QT interval, and thus assessing this risk could greatly facilitate the…”
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Support Vector Machine model for hERG inhibitory activities based on the integrated hERG database using descriptor selection by NSGA-II by Ogura, Keiji, Sato, Tomohiro, Yuki, Hitomi, Honma, Teruki

“…Assessing the hERG liability in the early stages of drug discovery programs is important. The recent increase of hERG-related information in public databases…”
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Constitutive NF-κB Activation in Colorectal Carcinoma Plays a Key Role in Angiogenesis, Promoting Tumor Growth by SAKAMOTO, Kei, MAEDA, Shin, HIKIBA, Yohko, NAKAGAWA, Hayato, HAYAKAWA, Yoku, SHIBATA, Wataru, YANAI, Ayako, OGURA, Keiji, OMATA, Masao

“…Purpose: Nuclear factor κB (NF-κB) is an important transcription factor in various biological processes. Constitutive NF-κB activation has been noted in many…”
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Prognostic significance of pathogenic variants in BRCA1, BRCA2, ATM and PALB2 genes in men undergoing hormonal therapy for advanced prostate cancer by Kimura, Hiroko, Mizuno, Kei, Shiota, Masaki, Narita, Shintaro, Terada, Naoki, Fujimoto, Naohiro, Ogura, Keiji, Hatano, Shotaro, Iwasaki, Yusuke, Hakozaki, Nozomi, Ishitoya, Satoshi, Sumiyoshi, Takayuki, Goto, Takayuki, Kobayashi, Takashi, Nakagawa, Hidewaki, Kamoto, Toshiyuki, Eto, Masatoshi, Habuchi, Tomonori, Ogawa, Osamu, Momozawa, Yukihide, Akamatsu, Shusuke

“…Background The prognostic significance of germline variants in homologous recombination repair genes in advanced prostate cancer (PCa), especially with regard…”
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Deletion of Apoptosis Signal-Regulating Kinase 1 Attenuates Acetaminophen-Induced Liver Injury by Inhibiting c-Jun N-Terminal Kinase Activation by Nakagawa, Hayato, Maeda, Shin, Hikiba, Yohko, Ohmae, Tomoya, Shibata, Wataru, Yanai, Ayako, Sakamoto, Kei, Ogura, Keiji, Noguchi, Takuya, Karin, Michael, Ichijo, Hidenori, Omata, Masao

“…Background & Aims: Acetaminophen (APAP) overdose is the most frequent cause of drug-induced liver failure. C-jun N-terminal kinase (JNK) is thought to play a…”
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Outcomes of Endoscopic Submucosal Dissection for Colorectal Epithelial Neoplasms in 200 Consecutive Cases by Fujishiro, Mitsuhiro, Yahagi, Naohisa, Kakushima, Naomi, Kodashima, Shinya, Muraki, Yosuke, Ono, Satoshi, Yamamichi, Nobutake, Tateishi, Ayako, Oka, Masashi, Ogura, Keiji, Kawabe, Takao, Ichinose, Masao, Omata, Masao

“…Background & Aims: The clinical outcomes for endoscopic submucosal dissection (ESD), a novel endoluminal surgery for gastrointestinal neoplasm in the…”
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Increased Frequency of Copy Number Variations Revealed by Array Comparative Genomic Hybridization in the Offspring of Male Mice Exposed to Low Dose-Rate Ionizing Radiation by Ogura, Keiji, Ayabe, Yoshiko, Harada, Chihiro, Tanaka, 3rd, Ignacia Braga, Tanaka, Satoshi, Komura, Jun-Ichiro

“…There is very little information on the transgenerational or genetic effects of low dose-rate ionizing radiation. We report the detection of the…”
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The Reduction in Gastric Atrophy after Helicobacter pylori Eradication Is Reduced by Treatment with Inhibitors of Gastric Acid Secretion by Niikura, Ryota, Hayakawa, Yoku, Hirata, Yoshihiro, Ogura, Keiji, Fujishiro, Mitsuhiro, Yamada, Atsuo, Ushiku, Tetsuo, Konishi, Mitsuru, Fukayama, Masashi, Koike, Kazuhiko

“…( ) eradication therapy may improve gastric atrophy and intestinal metaplasia, but the results of previous studies have not always been consistent. The aim of…”
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Acute Middle Gastrointestinal Bleeding Risk Associated with NSAIDs, Antithrombotic Drugs, and PPIs: A Multicenter Case-Control Study by Nagata, Naoyoshi, Niikura, Ryota, Yamada, Atsuo, Sakurai, Toshiyuki, Shimbo, Takuro, Kobayashi, Yuka, Okamoto, Makoto, Mitsuno, Yuzo, Ogura, Keiji, Hirata, Yoshihiro, Fujimoto, Kazuma, Akiyama, Junichi, Uemura, Naomi, Koike, Kazuhiko

“…Middle gastrointestinal bleeding (MGIB) risk has not been fully investigated due to its extremely rare occurrence and the need for multiple endoscopies to…”
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Reduction in Mutation Frequency by Very Low-Dose Gamma Irradiation of Drosophila melanogaster Germ Cells by Ogura, Keiji, Magae, Junji, Kawakami, Yasushi, Koana, Takao

“…Ogura, K., Magae, J., Kawakami, Y. and Koana, T. Reduction in Mutation Frequency by Very Low-Dose Gamma Irradiation of Drosophila melanogaster Germ Cells…”
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C-Jun NH2-Terminal Kinase 1 Is a Critical Regulator for the Development of Gastric Cancer in Mice by SHIBATA, Wataru, MAEDA, Shin, HIKIBA, Yohko, YANAI, Ayako, SAKAMOTO, Kei, NAKAGAWA, Hayato, OGURA, Keiji, KARIN, Michael, OMATA, Masao

“…c-Jun NH(2)-terminal kinase (JNK) links several cellular processes, including proliferation and survival, and is believed to be involved in carcinogenesis…”
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A Randomized Controlled Trial Evaluating the Usefulness of a Transparent Hood Attached to the Tip of the Colonoscope by KONDO, Shintaro, YAMAJI, Yutaka, OMATA, Masao, WATABE, Hirotsugu, YAMADA, Atsuo, SUGIMOTO, Takafumi, OHTA, Miki, OGURA, Keiji, OKAMOTO, Makoto, YOSHIDA, Haruhiko, KAWABE, Takao

“…Considering the increasing demand for colonoscopy, auxiliary devices that could facilitate the examination would be useful. A hood attached to the tip of the…”
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Assessment of the Risk Factors for Colonic Diverticular Hemorrhage by Yamada, Atsuo, Sugimoto, Takafumi, Kondo, Shintaro, Ohta, Miki, Watabe, Hirotsugu, Maeda, Shin, Togo, Goichi, Yamaji, Yutaka, Ogura, Keiji, Okamoto, Makoto, Yoshida, Haruhiko, Kawabe, Takao, Kawase, Tateo, Omata, Masao

“…Purpose Colonic diverticulosis, although usually asymptomatic, sometimes causes diverticular hemorrhage. Studies about risk factors, other than nonsteroidal…”
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Successful outcomes of a novel endoscopic treatment for GI tumors: endoscopic submucosal dissection with a mixture of high-molecular-weight hyaluronic acid, glycerin, and sugar by Fujishiro, Mitsuhiro, MD, PhD, Yahagi, Naohisa, MD, PhD, Nakamura, Masanori, MD, Kakushima, Naomi, MD, Kodashima, Shinya, MD, Ono, Satoshi, MD, Kobayashi, Katsuya, MD, Hashimoto, Takuhei, MD, Yamamichi, Nobutake, MD, PhD, Tateishi, Ayako, MD, Shimizu, Yasuhito, MD, PhD, Oka, Masashi, MD, PhD, Ogura, Keiji, MD, PhD, Kawabe, Takao, MD, PhD, Ichinose, Masao, MD, PhD, Omata, Masao, MD, PhD

“…Background Endoscopic submucosal dissection (ESD) has recently been developed for endoscopic treatment of GI tumors, which enables us to resect even large…”
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Essential roles of high-mobility group box 1 in the development of murine colitis and colitis-associated cancer by Maeda, Shin, Hikiba, Yohko, Shibata, Wataru, Ohmae, Tomoya, Yanai, Ayako, Ogura, Keiji, Yamada, Shingo, Omata, Masao

“…High-mobility group box 1 (HMGB1) is a nuclear factor released extracellularly as a proinflammatory cytokine. We measured the HMGB1 concentration in the sera…”
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Development of caged non-hydrolyzable phosphoamino acids and application to photo-control of binding affinity of phosphopeptide mimetic to phosphopeptide-recognizing protein by Ebisuno, Koji, Denda, Masaya, Ogura, Keiji, Inokuma, Tsubasa, Shigenaga, Akira, Otaka, Akira

“…The design and synthesis of caged non-hydrolyzable phospho-serine, -threonine, and -tyrosine derivatives that generate parent non-hydrolyzable phosphoamino…”
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Neutrophil infiltration and the distribution of intestinal metaplasia is associated with metachronous gastric cancer following endoscopic submucosal dissection by Sugimoto, Takafumi, Yamaji, Yutaka, Sakitani, Kosuke, Isomura, Yoshihiro, Yoshida, Shuntaro, Yamada, Atsuo, Hirata, Yoshihiro, Ogura, Keiji, Okamoto, Makoto, Koike, Kazuhiko

“…Endoscopic submucosal dissection (ESD) of early gastric cancer is a minimally invasive procedure. However, the risk for metachronous cancers after successful…”
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The Effect of Helicobacter pylori Eradication on Reducing the Incidence of Gastric Cancer by Ogura, Keiji, Hirata, Yoshihiro, Yanai, Ayako, Shibata, Wataru, Ohmae, Tomoya, Mitsuno, Yuzo, Maeda, Shin, Watabe, Hirotsugu, Yamaji, Yutaka, Okamoto, Makoto, Yoshida, Haruhiko, Kawabe, Takao, Omata, Masao

“…Epidemiologically, the association between chronic Helicobacter pylori infection and development of gastric cancer is well established. Although the…”
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Virulence factors of Helicobacter pylori responsible for gastric diseases in Mongolian gerbil by Ogura, K, Maeda, S, Nakao, M, Watanabe, T, Tada, M, Kyutoku, T, Yoshida, H, Shiratori, Y, Omata, M

“…Helicobacter pylori infection induces various gastroduodenal diseases. We examined the role of two genes, vacA and cagE, in the gastric pathogenesis induced by…”
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MyD88 and TNF Receptor-Associated Factor 6 Are Critical Signal Transducers in Helicobacter pylori-Infected Human Epithelial Cells by Hirata, Yoshihiro, Ohmae, Tomoya, Shibata, Wataru, Maeda, Shin, Ogura, Keiji, Yoshida, Haruhiko, Kawabe, Takao, Omata, Masao

“…Helicobacter pylori induces NF-kappaB activation, leading to mucosal inflammation via cag pathogenicity island. Although recent studies have implicated several…”
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