Search Results - "OGO, Naohisa"

Discovery of a New STAT3 Inhibitor Acting on the Linker Domain by Koseki, Tatsuya, Suehiro, Naoya, Masuda, Yoshiaki, Miyoshi, Nao, Muraoka, Daisuke, Ogo, Naohisa, Asai, Akira

“…Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that contributes to tumor cell growth and survival and is often…”
Get full text

Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling by Araki, Toshihiro, Watanabe, Yuuki, Okada, Yusuke, Murakami, Hisashi, Ogo, Naohisa, Asai, Akira

“…Signal transducer and activator of transcription 3 (STAT3) plays key roles in cancer cell proliferation, invasion, and immunosuppression. In many human cancer…”
Get full text

Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation by Sawada, Jun-ichi, Matsuno, Kenji, Ogo, Naohisa, Asai, Akira

“…[Display omitted] Kinesin-5 has received considerable attention as a new target for mitosis. Various small-molecule compounds targeting kinesin-5 have been…”
Get full text

Antitumor activity of a novel oral signal transducer and activator of transcription 3 inhibitor YHO‐1701 by Nishisaka, Fukiko, Taniguchi, Keisuke, Tsugane, Momomi, Hirata, Genya, Takagi, Akimitsu, Asakawa, Naoyuki, Kurita, Akinobu, Takahashi, Hiroyuki, Ogo, Naohisa, Shishido, Yoshiyuki, Asai, Akira

“…The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival and invasion…”
Get full text

Antiviral effect of theaflavins against caliciviruses by Ohba, Mai, Oka, Tomoichiro, Ando, Takayuki, Arahata, Saori, Ikegaya, Asaka, Takagi, Hirotaka, Ogo, Naohisa, Zhu, Chelsea, Owada, Kazuhiro, Kawamori, Fumihiko, Wang, Qiuhong, Saif, Linda J, Asai, Akira

“…Caliciviruses are contagious pathogens of humans and various animals. They are the most common cause of viral gastroenteritis in humans, and can cause lethal…”
Get full text

Involvement of phosphatidylinositol metabolism in aluminum-induced malate secretion in Arabidopsis by Wu, Liujie, Sadhukhan, Ayan, Kobayashi, Yuriko, Ogo, Naohisa, Tokizawa, Mutsutomo, Agrahari, Raj Kishan, Ito, Hiroki, Iuchi, Satoshi, Kobayashi, Masatomo, Asai, Akira, Koyama, Hiroyuki

“…To identify the upstream signaling of aluminum-induced malate secretion through aluminum-activated malate transporter 1 (AtALMT1), a pharmacological assay…”
Get full text

STX‐0119, a novel STAT3 dimerization inhibitor, prevents fibrotic gene expression in a mouse model of kidney fibrosis by regulating Cxcr4 and Ccr1 expression by Makitani, Kouki, Ogo, Naohisa, Asai, Akira

“…Kidney fibrosis is a histological hallmark of chronic kidney disease (CKD) and is believed to be involved in the progression of CKD. Therefore, inhibition of…”
Get full text

Structural Basis of New Allosteric Inhibition in Kinesin Spindle Protein Eg5 by Yokoyama, Hideshi, Sawada, Jun-ichi, Katoh, Shiori, Matsuno, Kenji, Ogo, Naohisa, Ishikawa, Yoshinobu, Hashimoto, Hiroshi, Fujii, Satoshi, Asai, Akira

“…Kinesin spindle protein Eg5 is a target for anticancer therapies, and small molecule inhibitors of its ATPase activity have been developed. We herein report…”
Get full text

Visualization and quantification of dynamic STAT3 homodimerization in living cells using homoFluoppi by Okada, Yusuke, Watanabe, Taku, Shoji, Toru, Taguchi, Kyoko, Ogo, Naohisa, Asai, Akira

“…Dimerization in signal transduction is a dynamically regulated process and a key regulatory mechanism. Signal transducer and activator of transcription 3…”
Get full text

STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis by Yanagimura, Naohiro, Takeuchi, Shinji, Fukuda, Koji, Arai, Sachiko, Tanimoto, Azusa, Nishiyama, Akihiro, Ogo, Naohisa, Takahashi, Hiroyuki, Asai, Akira, Watanabe, Satoshi, Kikuchi, Toshiaki, Yano, Seiji

“…Patients with advanced anaplastic lymphoma kinase ( ALK )-rearranged non-small cell lung cancer who are prescribed ALK-tyrosine kinase inhibitors (ALK-TKIs)…”
Get full text

Inhibition of STAT3 by Anticancer Drug Bendamustine by Iwamoto, Kazunori, Uehara, Yutaka, Inoue, Yukie, Taguchi, Kyoko, Muraoka, Daisuke, Ogo, Naohisa, Matsuno, Kenji, Asai, Akira

“…Bendamustine (BENDA), which bears the bis(2-chloroethyl)amino moiety, is an alkylating agent that stops the growth of cancer cells by binding to DNA and…”
Get full text

Epirubicin, Identified Using a Novel Luciferase Reporter Assay for Foxp3 Inhibitors, Inhibits Regulatory T Cell Activity by Kashima, Hajime, Momose, Fumiyasu, Umehara, Hiroshi, Miyoshi, Nao, Ogo, Naohisa, Muraoka, Daisuke, Shiku, Hiroshi, Harada, Naozumi, Asai, Akira

“…Forkhead box protein p3 (Foxp3) is crucial to the development and suppressor function of regulatory T cells (Tregs) that have a significant role in…”
Get full text

Effect of the STAT3 inhibitor STX-0119 on the proliferation of cancer stem-like cells derived from recurrent glioblastoma by ASHIZAWA, TADASHI, MIYATA, HARUO, IIZUKA, AKIRA, KOMIYAMA, MASARU, OSHITA, CHIE, KUME, AKIKO, NOGAMI, MASAHIRO, YAGOTO, MIKA, ITO, ICHIRO, OISHI, TAKUMA, WATANABE, REIKO, MITSUYA, KOICHI, MATSUNO, KENJI, FURUYA, TOSHIO, OKAWARA, TADASHI, OTSUKA, MASAMI, OGO, NAOHISA, ASAI, AKIRA, NAKASU, YOKO, YAMAGUCHI, KEN, AKIYAMA, YASUTO

“…Signal transducer and activator of transcription (STAT) 3, a member of a family of DNA-binding molecules, is a potential target in the treatment of cancer. The…”
Get full text

Fluvoxamine, an anti-depressant, inhibits human glioblastoma invasion by disrupting actin polymerization by Hayashi, Keiichiro, Michiue, Hiroyuki, Yamada, Hiroshi, Takata, Katsuyoshi, Nakayama, Hiroki, Wei, Fan-Yan, Fujimura, Atsushi, Tazawa, Hiroshi, Asai, Akira, Ogo, Naohisa, Miyachi, Hiroyuki, Nishiki, Tei-ichi, Tomizawa, Kazuhito, Takei, Kohji, Matsui, Hideki

“…Glioblastoma multiforme (GBM) is the most common malignant brain tumor with a median survival time about one year. Invasion of GBM cells into normal brain is…”
Get full text

Discovery and Synthesis of Heterocyclic Carboxamide Derivatives as Potent Anti-norovirus Agents by Ohba, Mai, Oka, Tomoichiro, Ando, Takayuki, Arahata, Saori, Ikegaya, Asaka, Takagi, Hirotaka, Ogo, Naohisa, Owada, Kazuhiro, Kawamori, Fumihiko, Wang, Qiuhong, Saif, Linda J., Asai, Akira

“…There is an urgent need for structurally novel anti-norovirus agents. In this study, we describe the synthesis, anti-norovirus activity, and structure–activity…”
Get full text

Identification and Characterization of a Novel Dual Inhibitor of Indoleamine 2,3-dioxygenase 1 and Tryptophan 2,3-dioxygenase by Yoshioka, Saeko, Ikeda, Tomonori, Fukuchi, Sogo, Kawai, Yurika, Ohta, Katsumi, Murakami, Hisashi, Ogo, Naohisa, Muraoka, Daisuke, Takikawa, Osamu, Asai, Akira

“…Kynurenine (Kyn), a metabolite of tryptophan (Trp), is a key regulator of mammal immune responses such as cancer immune tolerance. Indoleamine-2,3-dioxygenase…”
Get full text

Novel multiplexed assay for identifying SH2 domain antagonists of STAT family proteins by Takakuma, Kazuyuki, Ogo, Naohisa, Uehara, Yutaka, Takahashi, Susumu, Miyoshi, Nao, Asai, Akira

“…Some of the signal transducer and activator of transcription (STAT) family members are constitutively activated in a wide variety of human tumors. The activity…”
Get full text

Identification of a New Series of STAT3 Inhibitors by Virtual Screening by Matsuno, Kenji, Masuda, Yoshiaki, Uehara, Yutaka, Sato, Hiroshi, Muroya, Ayumu, Takahashi, Osamu, Yokotagawa, Takane, Furuya, Toshio, Okawara, Tadashi, Otsuka, Masami, Ogo, Naohisa, Ashizawa, Tadashi, Oshita, Chie, Tai, Sachiko, Ishii, Hidee, Akiyama, Yasuto, Asai, Akira

“…The signal transducer and activator of transcription 3 (STAT3) is considered to be an attractive therapeutic target for oncology drug development. We…”
Get full text

Chemical augmentation of mitochondrial electron transport chains tunes T cell activation threshold in tumors by Dotsu, Yosuke, Muraoka, Daisuke, Ogo, Naohisa, Sonoda, Yudai, Yasui, Kiyoshi, Yamaguchi, Hiroyuki, Yagita, Hideo, Mukae, Hiroshi, Asai, Akira, Ikeda, Hiroaki

“…BackgroundCancer immunotherapy shows insufficient efficacy for low immunogenic tumors. Furthermore, tumors often downregulate antigen and major…”
Get full text

The Lipid-Binding Defective Dynamin 2 Mutant in Charcot-Marie-Tooth Disease Impairs Proper Actin Bundling and Actin Organization in Glomerular Podocytes by Hamasaki, Eriko, Wakita, Natsuki, Yasuoka, Hiroki, Nagaoka, Hikaru, Morita, Masayuki, Takashima, Eizo, Uchihashi, Takayuki, Takeda, Tetsuya, Abe, Tadashi, Lee, Ji-Won, Iimura, Tadahiro, Saleem, Moin A, Ogo, Naohisa, Asai, Akira, Narita, Akihiro, Takei, Kohji, Yamada, Hiroshi

“…Dynamin is an endocytic protein that functions in vesicle formation by scission of invaginated membranes. Dynamin maintains the structure of foot processes in…”
Get full text