Search Results - "OGAWA, Nobuya"

JTT-553, a novel Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 inhibitor, improves glucose metabolism in diet-induced obesity and genetic T2DM mice by Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Kobayashi, Akio, Ohta, Takeshi, Kakutani, Makoto, Imanaka, Tsuneo, Ogawa, Nobuya

“…Type 2 diabetes mellitus (T2DM) arises primarily due to lifestyle factors and genetics. A number of lifestyle factors are known to be important in the…”
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Pharmacological Characterization of [trans-5′-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2′,3′-dihydrospiro(cyclohexane-1,1′-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA:Diacylglycerol Transferase (DGAT) 1 Inhibitor by Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya

“…Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. This enzyme is considered to be a…”
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Intestinal fatty acid infusion modulates food preference as well as calorie intake via the vagal nerve and midbrain–hypothalamic neural pathways in rats by Ogawa, Nobuya, Ito, Makoto, Yamaguchi, Hideki, Shiuchi, Tetsuya, Okamoto, Shiki, Wakitani, Korekiyo, Minokoshi, Yasuhiko, Nakazato, Masamitsu

“…Abstract The intestine plays important roles in the regulation of feeding behavior by sensing macronutrients. Intestinal fatty acids strongly suppress food…”
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A comparative double-blind randomized trial of activated protein C and unfractionated heparin in the treatment of disseminated intravascular coagulation by AOKI, Nobuo, MATSUDA, Tamotsu, SAITO, Hidehiko, TAKATSUKI, Kiyoshi, OKAJIMA, Kenji, TAKAHASHI, Hoyu, TAKAMATSU, Junki, ASAKURA, Hidesaku, OGAWA, Nobuya

“…A randomized prospective double-blind trial was performed to compare the safety and efficacy of human activated protein C (APC) and unfractionated heparin for…”
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Cell cycle-dependent chronotoxicity of irinotecan hydrochloride in mice by Ohdo, S, Makinosumi, T, Ishizaki, T, Yukawa, E, Higuchi, S, Nakano, S, Ogawa, N

“…The mechanisms underlying the circadian rhythm of the toxicity induced by irinotecan hydrochloride (CPT-11;…”
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Vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide receptor chimeras reveal domains that determine specificity of vasoactive intestinal polypeptide binding and activation by Hashimoto, H, Ogawa, N, Hagihara, N, Yamamoto, K, Imanishi, K, Nogi, H, Nishino, A, Fujita, T, Matsuda, T, Nagata, S, Baba, A

“…Vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) receptors are closely related G protein-coupled…”
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JTP‐109192, a novel G protein‐coupled receptor 119 agonist, prevents atherosclerosis by improving hypercholesterolaemia in congenic spontaneously hyperlipidaemic mice by Tadaki, Hironobu, Ogawa, Naoto, Yamanaka, Masao, Motohashi, Yu, Sasase, Tomohiko, Kawai, Takashi, Toriniwa, Yasufumi, Fukuda, Sumiaki, Ogawa, Nobuya, Harada, Kazuhito, Ohta, Takeshi, Yamada, Takahisa

“…G protein‐coupled receptor 119 (GPR119) expression in pancreatic β‐cells and intestinal L‐cells is a potential therapeutic target for the treatment of type 2…”
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Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor by Aino, Hiroshi, Hashimoto, Hitoshi, Ogawa, Nobuya, Nishino, Akiko, Yamamoto, Kyohei, Nogi, Hiroyuki, Nagata, Shigekazu, Baba, Akemichi

“…The PACAP-R gene, encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor (PACAP-R), has been isolated and its structural organization…”
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Safety and Efficacy of the Neuraminidase Inhibitor Zanamivir in Treating Influenza Virus Infection in Adults: Results from Japan by Matsumoto, Keizo, Ogawa, Nobuya, Nerome, Kuniaki, Numazaki, Yoshio, Kawakami, Yoshikazu, Shirato, Kunio, Arakawa, Masaaki, Kudoh, Shoji, Shimokata, Kaoru, Nakajima, Shigenori, Yamakido, Michio, Kashiwagi, Seizaburo, Nagatake, Tsuyoshi, Kawakami, Y, Miyamoto, H, Inoue, H, Shirato, K, Miura, Y, Watanabe, A, Nakai, Y, Ishii, M, Sakamoto, M, Kudoh, S, Abe, S, Yamaguchi, T, Arakawa, M, Sega, H, Shimatsu, Y, Yoshimine, F, Shimokata, K, Masuda, T, Yamamoto, M, Iwata, M, Nakajima, S, Ito, M, Takeda, T, Ohsawa, N, Kato, M, Yamakido, M, Takahashi, J, Miyazawa, T, Soejima, R, Sasaki, T, Nagatake, T, Masaki, H, Kashiwagi, S, Ueno, K, Hayashida, K, Ando, M, Ikegami, A

“…The study was carried out to evaluate the therapeutic effects of zanamivir, a highly selective, potent and specific inhibitor of influenza A and B virus…”
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Chronopharmacology of granulocyte colony-stimulating factor in mice by Ohdo, S, Arata, N, Furukubo, T, Yukawa, E, Higuchi, S, Nakano, S, Ogawa, N

“…The role of the sensitivity of bone marrow cells to, and the pharmacokinetics of granulocyte colony-stimulating factor (G-CSF) on the rhythm of…”
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Feeding conditions and estrous cycle of female rats under the activity-stress procedure from aspects of anorexia nervosa by Watanabe, K, Hara, C, Ogawa, N

“…The present study investigated the application of female rats with activity stress as an animal model for anorexia nervosa. Young female rats were singly…”
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Alteration in circadian rhythm of plasma corticosterone in rats following sociopsychological stress induced by communication box by Ishikawa, Masahiro, Ohdo, Shigehiro, Watanabe, Hirokazu, Hara, Chiaka, Ogawa, Nobuya

“…The purpose of present study was to investigate the physiological characteristics of sociopsychological stress induced by the communication box method. In this…”
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Pharmacological Characterization of [trans-5'-(4-Amino-7,7-dimethyl-2-trifluoromethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)-2',3'-dihydrospiro(cyclohexane-1,1'-inden)-4-yl]acetic Acid Monobenzenesulfonate (JTT-553), a Novel Acyl CoA by Tomimoto, Daisuke, Okuma, Chihiro, Ishii, Yukihito, Akiyama, Yoshiyuki, Ohta, Takeshi, Kakutani, Makoto, Ohkuma, Yoshiaki, Ogawa, Nobuya

“…Acyl CoA:diacylglycerol acyltransferase (DGAT) 1 is an enzyme that catalyzes the final step in triglyceride (TG) synthesis. This enzyme is considered to be a…”
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Ethopharmacology of maternal aggression in mice: effects of diazepam and SM-3997 by Yoshimura, H, Ogawa, N

“…The present study investigated whether there is any difference between the effects of benzodiazepine and non-benzodiazepine anxiolytics on maternal aggression…”
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Peptic ulcer recurrence during maintenance therapy with H 2 -receptor antagonist following first-line therapy with proton pump inhibitor by Kaneko, Eizo, Hoshihara, Yoshio, Sakaki, Nobuhiro, Harasawa, Shigeru, Ashida, Kiyoshi, Asaka, Masahiro, Asaki, Shigeru, Nakamura, Takashi, Kobayashi, Kenzo, Kajiyama, Goro, Ogawa, Nobuya, Yao, Tsuneyoshi, Muto, Yasutoshi, Nakazawa, Saburo, Takemoto, Tadayoshi

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Circadian changes of valproate kinetics depending on meal condition in humans by Ohdo, S, Nakano, S, Ogawa, N

“…The objective of this study was to examine the effect of meal condition on circadian changes in valproic acid (VPA) kinetics. Two experiments were performed in…”
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Discovery of 6‑Phenylpyrimido[4,5‑b][1,4]oxazines as Potent and Selective Acyl CoA:Diacylglycerol Acyltransferase 1 (DGAT1) Inhibitors with in Vivo Efficacy in Rodents by Fox, Brian M, Sugimoto, Kazuyuki, Iio, Kiyosei, Yoshida, Atsuhito, Zhang, Jian (Ken), Li, Kexue, Hao, Xiaolin, Labelle, Marc, Smith, Marie-Louise, Rubenstein, Steven M, Ye, Guosen, McMinn, Dustin, Jackson, Simon, Choi, Rebekah, Shan, Bei, Ma, Ji, Miao, Shichang, Matsui, Takuya, Ogawa, Nobuya, Suzuki, Masahiro, Kobayashi, Akio, Ozeki, Hidekazu, Okuma, Chihiro, Ishii, Yukihito, Tomimoto, Daisuke, Furakawa, Noboru, Tanaka, Masahiro, Matsushita, Mutsuyoshi, Takahashi, Mitsuru, Inaba, Takashi, Sagawa, Shoichi, Kayser, Frank

“…The discovery and optimization of a series of acyl CoA:diacylglycerol acyltransferase 1 (DGAT1) inhibitors based on a pyrimido[4,5-b][1,4]oxazine scaffold is…”
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Influence of dosing time on pharmacological action of G-CSF in mice by Ohdo, Shigehiro, Furukubo, Taku, Arata, Naoko, Yukawa, Eiji, Higuchi, Shun, Nakano, Shigeyuki, Ogawa, Nobuya

“…The role of the susceptibility of living organisms and the pharmacokinetics of G-CSF on the rhythm of granulocyte colony-stimulating factor (G-CSF) activity…”
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Chronopharmacological study of KE-SI-TO components in mice by Ohdo, Shigehiro, Ogawa, Nobuya, Song, Jian Guo, Higuchi, Shun

“…Influence of dosing time on pharmacological effects and toxicity of KE-SI-TO (KST) components, as well as the role of each component in the circadian rhythms…”
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A comparative trial of LC9018 plus doxorubicin and doxorubicin alone for the treatment of malignant pleural effusion secondary to lung cancer by Masuno, T, Kishimoto, S, Ogura, T, Honma, T, Niitani, H, Fukuoka, M, Ogawa, N

“…The efficacy and safety of intrapleural LC9018 (Yakult Co. Ltd., Tokyo, Japan) with or without doxorubicin (Adriamycin; Adria Laboratories, Columbus, OH) were…”
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