Search Results - "OGATA, Hisanobu"

Identification of Liver Cancer Progenitors Whose Malignant Progression Depends on Autocrine IL-6 Signaling by He, Guobin, Dhar, Debanjan, Nakagawa, Hayato, Font-Burgada, Joan, Ogata, Hisanobu, Jiang, Yuhong, Shalapour, Shabnam, Seki, Ekihiro, Yost, Shawn E., Jepsen, Kristen, Frazer, Kelly A., Harismendy, Olivier, Hatziapostolou, Maria, Iliopoulos, Dimitrios, Suetsugu, Atsushi, Hoffman, Robert M., Tateishi, Ryosuke, Koike, Kazuhiko, Karin, Michael

“…Hepatocellular carcinoma (HCC) is a slowly developing malignancy postulated to evolve from premalignant lesions in chronically damaged livers. However, it was…”
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Clinical Trial of a Cancer Vaccine Targeting VEGF and KIF20A in Advanced Biliary Tract Cancer by Murahashi, Mutsunori, Tsuruta, Toshihisa, Yamada, Kazunari, Hijikata, Yasuki, Ogata, Hisanobu, Kishimoto, Junji, Yoshimura, Sachiko, Hikichi, Tetsuro, Nakanishi, Yoichi, Tani, Kenzaburo

“…As the prognosis of biliary tract cancer (BTC) is extremely poor and treatment options are limited, new treatment modalities are urgently needed. We designed a…”
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RBPJ and MAML3: Potential Therapeutic Targets for Small Cell Lung Cancer by Onishi, Hideya, Ichimiya, Shu, Yanai, Kosuke, Umebayashi, Masayo, Nakamura, Katsuya, Yamasaki, Akio, Imaizumi, Akira, Nagai, Shuntaro, Murahashi, Mutsunori, Ogata, Hisanobu, Morisaki, Takashi

“…Small cell lung cancer (SCLC) is still a deadly type of cancer for which there are few effective therapeutic strategies. Development of a new molecule…”
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Hepatitis C Virus Down-Regulates Insulin Receptor Substrates 1 and 2 through Up-Regulation of Suppressor of Cytokine Signaling 3 by Kawaguchi, Takumi, Yoshida, Takafumi, Harada, Masaru, Hisamoto, Takao, Nagao, Yumiko, Ide, Tatsuya, Taniguchi, Eitaro, Kumemura, Hiroto, Hanada, Shinichiro, Maeyama, Michiko, Baba, Shinji, Koga, Hironori, Kumashiro, Ryukichi, Ueno, Takato, Ogata, Hisanobu, Yoshimura, Akihiko, Sata, Michio

“…The pathogenesis of hepatitis C virus (HCV)-associated insulin resistance remains unclear. Therefore, we investigated mechanisms for HCV-associated insulin…”
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A Novel Combination Therapy for Human Oxaliplatin-resistant Colorectal Cancer Using Oxaliplatin and Coxsackievirus A11 by Wang, Beibei, Ogata, Hisanobu, Takishima, Yuto, Miyamoto, Shohei, Inoue, Hiroyuki, Kuroda, Masaki, Yamada, Kazunari, Hijikata, Yasuki, Murahashi, Mutsunori, Shimizu, Hiroyuki, Okazaki, Toshihiko, Nakanishi, Yoichi, Tani, Kenzaburo

“…Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world. It is the third most common cancer worldwide and the fourth most…”
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Deletion of the SOCS3 Gene in Liver Parenchymal Cells Promotes Hepatitis–Induced Hepatocarcinogenesis by Ogata, Hisanobu, Kobayashi, Takashi, Chinen, Takatoshi, Takaki, Hiromi, Sanada, Takahito, Minoda, Yasumasa, Koga, Keiko, Takaesu, Giichi, Maehara, Yoshihiko, Iida, Mitsuo, Yoshimura, Akihiko

“…Background & Aims: A recent study has suggested that the methylation silencing of the suppressor of cytokine signaling-3 (SOCS3), a negative regulator of…”
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Dietary sucrose is essential to the development of liver injury in the methionine-choline-deficient model of steatohepatitis[S] by Pickens, Michael K., Yan, Jim S., Ng, Raymond K., Ogata, Hisanobu, Grenert, James P., Beysen, Carine, Turner, Scott M., Maher, Jacquelyn J.

“…Methionine-choline-deficient (MCD) diets cause steatohepatitis in rodents and are used to study the pathophysiology of fatty liver disease in human beings. The…”
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SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis by Yoshida, Takafumi, Ogata, Hisanobu, Kamio, Masaki, Joo, Akiko, Shiraishi, Hiroshi, Tokunaga, Yoko, Sata, Michio, Nagai, Hisaki, Yoshimura, Akihiko

“…Hepatocellular carcinomas (HCCs) mainly develop from liver cirrhosis and severe liver fibrosis that are established with long-lasting inflammation of the…”
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SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein by KAMIO, Masaki, YOSHIDA, Takafumi, OGATA, Hisanobu, DOUCHI, Tsutomu, NAGATA, Yukihiro, INOUE, Makoto, HASEGAWA, Mamoru, YONEMITSU, Yoshikazu, YOSHIMURA, Akihiko

“…Human papilloma viruses (HPVs) are small double-stranded DNA viruses that infect mucosal and cutaneous epithelium and induce cervical cancer. It has been shown…”
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Tobacco Smoke Promotes Lung Tumorigenesis by Triggering IKKβ- and JNK1-Dependent Inflammation by Takahashi, Hiroyuki, Ogata, Hisanobu, Nishigaki, Reiko, Broide, David H., Karin, Michael

“…Chronic exposure to tobacco smoke, which contains over 60 tumor-initiating carcinogens, is the major risk factor for development of lung cancer, accounting for…”
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ER Stress Cooperates with Hypernutrition to Trigger TNF-Dependent Spontaneous HCC Development by Nakagawa, Hayato, Umemura, Atsushi, Taniguchi, Koji, Font-Burgada, Joan, Dhar, Debanjan, Ogata, Hisanobu, Zhong, Zhenyu, Valasek, Mark A., Seki, Ekihiro, Hidalgo, Juan, Koike, Kazuhiko, Kaufman, Randal J., Karin, Michael

“…Endoplasmic reticulum (ER) stress has been implicated in the pathogenesis of viral hepatitis, insulin resistance, hepatosteatosis, and nonalcoholic…”
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WSX-1 over-expression in CD4+ T cells leads to hyperproliferation and cytokine hyperproduction in response to TCR stimulation by Takeda, Atsunobu, Hamano, Shinjiro, Shiraishi, Hiroshi, Yoshimura, Takeru, Ogata, Hisanobu, Ishii, Kazunari, Ishibashi, Tatsuro, Yoshimura, Akihiko, Yoshida, Hiroki

“…WSX-1 is a component of the IL-27R. Analyses of WSX-1 knockout (WSX-1−/−) mice have shown that IL-27/WSX-1 signaling is essential for the proper development of…”
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Hepatocyte IKKβ/NF-κB Inhibits Tumor Promotion and Progression by Preventing Oxidative Stress-Driven STAT3 Activation by He, Guobin, Yu, Guann-Yi, Temkin, Vladislav, Ogata, Hisanobu, Kuntzen, Christian, Sakurai, Toshiharu, Sieghart, Wolfgang, Peck-Radosavljevic, Markus, Leffert, Hyam L., Karin, Michael

“…The NF-κB activating kinase IKKβ suppresses early chemically induced liver tumorigenesis by inhibiting hepatocyte death and compensatory proliferation. To…”
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Erratum: SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein by Kamio, Masaki, Yoshida, Takafumi, Ogata, Hisanobu, Douchi, Tsutomu, Nagata, Yukihiro, Inoue, Makoto, Hasegawa, Mamoru, Yonemitsu, Yoshikazu, Yoshimura, Akihiko

“…Correction to: Oncogene (2004) 23, 3107–3115. doi:10.1038/sj.onc.1207453 Owing to a typesetting error, the title of the above article was published…”
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An HNF4α-miRNA Inflammatory Feedback Circuit Regulates Hepatocellular Oncogenesis by Hatziapostolou, Maria, Polytarchou, Christos, Aggelidou, Eleni, Drakaki, Alexandra, Poultsides, George A., Jaeger, Savina A., Ogata, Hisanobu, Karin, Michael, Struhl, Kevin, Hadzopoulou-Cladaras, Margarita, Iliopoulos, Dimitrios

“…Hepatocyte nuclear factor 4α (HNF4α) is essential for liver development and hepatocyte function. Here, we show that transient inhibition of HNF4α initiates…”
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Abstract 4779: Coxsackievirus A11 as a novel oncolytic viral therapy for human colorectal cancer by Ogata, Hisanobu, Wang, Beibei, Miyamoto, Shoei, Takishima, Yuto, Sagara, Miyako, Murahashi, Mutsunori, Onishi, Hideya, Tani, Kenzaburo

“…Colorectal cancer (CRC) is a major cause of morbidity and mortality throughout the world. It is the third most common cancer worldwide and the fourth most…”
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Loss of acinar cell IKKα triggers spontaneous pancreatitis in mice by Li, Ning, Wu, Xuefeng, Holzer, Ryan G, Lee, Jun-Hee, Todoric, Jelena, Park, Eek-Joong, Ogata, Hisanobu, Gukovskaya, Anna S, Gukovsky, Ilya, Pizzo, Donald P, VandenBerg, Scott, Tarin, David, Atay, Ciǧdem, Arkan, Melek C, Deerinck, Thomas J, Moscat, Jorge, Diaz-Meco, Maria, Dawson, David, Erkan, Mert, Kleeff, Jörg, Karin, Michael

“…Chronic pancreatitis is an inflammatory disease that causes progressive destruction of pancreatic acinar cells and, ultimately, loss of pancreatic function. We…”
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Investigator initiated clinical trial of cancer vaccine OCV-C01 in advanced and recurrent biliary tract cancer by Murahashi, Mutsunori, Ogata, Hisanobu, Okazaki, Toshihiko, Hijikata, Yasuki, Yamada, Kazunari, Tsuruta, Toshihisa, Kishimoto, Junji, Funakoshi, Kouta, Todaka, Koji, Nakanishi, Yoichi, Tani, Kenzaburo

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O3-2-3Investigator initiated clinical trial of cancer vaccine OCV-C01 in advanced and recurrent biliary tract cancer by Murahashi, Mutsunori, Ogata, Hisanobu, Okazaki, Toshihiko, Hijikata, Yasuki, Yamada, Kazunari, Tsuruta, Toshihisa, Kishimoto, Junji, Funakoshi, Kouta, Todaka, Koji, Nakanishi, Yoichi, Tani, Kenzaburo

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Portal blood flow and glucose tolerance or peripheral insulin and glucagon concentrations in patients with liver cirrhosis by Iwase, Masanori, Ogata, Hisanobu, Tashiro, Kenji, Tsuji, Hiroshi, Yoshinari, Mototaka

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