Search Results - "OFNER, Clyde M"

Cytotoxic mechanisms of doxorubicin at clinically relevant concentrations in breast cancer cells by Nicoletto, Rachel E., Ofner, Clyde M.

“…Doxorubicin (DOX) is a chemotherapeutic agent frequently used for the treatment of a variety of tumor types, such as breast cancer. Despite the long history of…”
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Carbodiimide Induced Cross-Linking, Ligand Addition, and Degradation in Gelatin by Cammarata, Christopher R, Hughes, Mitchell E, Ofner, Clyde M

“…The water-soluble carbodiimide, 1-ethyl-3-(3-(dimethylaminopropyl)-carbodiimide (EDC) is widely used in protein chemistry. We used EDC-induced gelatin…”
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Intracellular trafficking and cytotoxicity of a gelatine-doxorubicin conjugate in two breast cancer cell lines by Alvi, Mohammed M., Nicoletto, Rachel E., Eshmawi, Bayan A., Kim, Hyun (Kate), Cammarata, Christopher R., Ofner, Clyde M.

“…Details of intracellular pathways of cytotoxicity remain unclear for doxorubicin conjugates being studied to treat breast cancer tumours. A high molecular…”
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Adsorption and Degradation of Doxorubicin from Aqueous Solution in Polypropylene Containers by Wu, Darren C., Ofner, Clyde M.

“…The purpose of this study was to examine doxorubicin adsorption in polypropylene containers as a function of pH and drug concentration based on anecdotal…”
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Effect of Molecular Weight, Drug Load, and Charge of Gelatin-MTX Conjugates on Growth Inhibition of HL-60 Leukemia Cells by Chen, Chao-Sheng, Ofner, Clyde M. III

“…Purpose Gelatin-methotrexate conjugates (G-MTX) with known molecular weight (MW), drug load, and charge were prepared and evaluated for growth inhibition on…”
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Preparation, Drug Release, and Cell Growth Inhibition of a Gelatin: Doxorubicin Conjugate by Wu, Darren C., Cammarata, Christopher R., Park, Hyun Joo, Rhodes, Brian T., Ofner, Clyde M.

“…Purpose To demonstrate the feasibility of a novel macromolecular delivery system for doxorubicin (DOX) which combines pH dependent DOX release with a high…”
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Gelatin-methotrexate conjugate microspheres as a potential drug delivery system by Pica, Karen, Tchao, Ruy, Ofner, 3rd, Clyde M

“…Gelatin-methotrexate microspheres for intra-tumor administration have possibilities for minimizing systemic toxicities of methotrexate (MTX) and overcoming its…”
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Growth inhibition, drug load, and degradation studies of gelatin/methotrexate conjugates by Ofner, Clyde M., Pica, Karen, Bowman, Bill J., Chen, Chao-Sheng

“…Macromolecular gelatin-methotrexate conjugates have potential therapeutic advantages over the free drug. Conjugates with MTX:gelatin molar ratios (MR) ranging…”
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Crosslinked gelatin matrices: release of a random coil macromolecular solute by Mwangi, Jane W., Ofner, Clyde M.

“…The purpose of this investigation was to evaluate the effect of matrix crosslinking and solute size on release of a random coil macromolecular solute from…”
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Multitemperature Stability and Degradation Characteristics of Pergolide Mesylate Oral Liquid by Shank, Brandon R., Ofner, Clyde M.

“…The stability of pergolide mesylate in an oral aqueous liquid was studied. Stability and solubility data were used to determine the degradation characteristics…”
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Crosslinking studies in gelatin capsules treated with formaldehyde and in capsules exposed to elevated temperature and humidity by Ofner, 3rd, C M, Zhang, Y E, Jobeck, V C, Bowman, B J

“…Incomplete in vitro capsule shell dissolution and subsequent drug release problems have recently received attention. A modified USP dissolution method was used…”
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Abstract LB103: Investigating the roles of reactive oxygen species and lysosomes in the cytotoxicity of doxorubicin in breast cancer cells by Nicoletto, Rachel E., Ofner, Clyde M.

“…Abstract Background: Nuclear events play a well-established role in the cytotoxicity of doxorubicin (DOX). Other reported mechanisms include redox cycling for…”
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Stability of Pergolide Mesylate Oral Liquid at Room Temperature by Shank, Brandon R, Ofner, Clyde M

“…Pergolide mesylate (proprietary name Permax) is used to treat equine Cushing's syndrome. Since pergolide mesylate has been removed from the market, the tablets…”
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Abstract 5387: Investigating the role of p53 in doxorubicin-mediated lysosome membrane permeabilization in breast cancer cells by Nicoletto, Rachel, Ofner, Clyde M.

“…Abstract Background: Doxorubicin (DOX) is a chemotherapeutic characterized by multiple mechanisms. Wild-type p53 (WTp53) may be activated in the presence of…”
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Abstract 2954: Investigating the role of lysosome permeabilization for doxorubicin cytotoxicity in breast cancer cells by Nicoletto, Rachel E., Alvi, Mohammed M., Ofner, Clyde M.

“…Abstract Background: The nuclear cytotoxic pathway of doxorubicin (DOX) is well established. Other mechanisms include reactive oxygen specie (ROS) interactions…”
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Abstract 2091: Lysosomal targeting of doxorubicin induces different membrane permeabilization and cytotoxicity in two breast cancer cell lines by Alvi, Mohammed, Nicoletto, Rachel, Eshmawi, Bayan A., Ofner, Clyde M.

“…Abstract Background: Lysosomal targeting has been investigated for the treatment of cancer but details of the resulting cytotoxicity remain unclear. The…”
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Stability of pergolide mesylate oral liquid at room temerature by Shank, Brandon R, Ofner , III, Clyde M

“…Pergolide mesylate (proprietary name Permax) is used to treat equine Cushing's syndrome. Since pergolide mesylate has been removed from the market, the tablets…”
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Characterization and in vitro release of methotrexate from gelatin/methotrexate conjugates formed using different preparation variables by Kosasih, A, Bowman, Bill J, Wigent, Rodney J, Ofner, Clyde M

“…The purpose of this study was to evaluate effects of preparation variables on the composition of gelatin-methotrexate conjugates, and to evaluate their in…”
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Abstract 2527: Investigation of doxorubicin interference in flow cytometry measurements of apoptosis and necrosis by Nicoletto, Rachel E., Wilkes, Richard, Ofner, Clyde M.

“…Abstract Background: Doxorubicin (DOX) is frequently used for investigations of breast cancer using flow cytometry with fluorescent stains for apoptosis and…”
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Characterization and in vitro methotrexate release from methotrexate/gelatin conjugates of opposite conjugate bond polarity by BOWMAN, Bill J, OFNER, Clyde M

“…Our laboratory has previously prepared gelatin/ methotrexate (MTX) conjugates containing mixed conjugation sites and by-product crosslinking, both of which may…”
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