Search Results - "OFFNER, H"

Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke by Ren, Xuefang, Akiyoshi, Kozaburo, Dziennis, Suzan, Vandenbark, Arthur A, Herson, Paco S, Hurn, Patricia D, Offner, Halina

“…Evaluation of infarct volumes and infiltrating immune cell populations in mice after middle cerebral artery occlusion (MCAO) strongly implicates a mixture of…”
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Effect of experimental stroke on peripheral immunity: CNS ischemia induces profound immunosuppression by Offner, H, Vandenbark, A.A, Hurn, P.D

“…Abstract The profound damage to the CNS caused by ischemic lesions has been well documented. Yet, relatively little is known about the contribution to and…”
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Neuroimmunoprotective effects of estrogen and derivatives in experimental autoimmune encephalomyelitis: Therapeutic implications for multiple sclerosis by Offner, Halina

“…The extensive literature and the work from our laboratory illustrate the large number of complex processes affected by estrogen that might contribute to the…”
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Quality of Life, Psychosocial Well-Being, and Sexual Satisfaction in Women with Polycystic Ovary Syndrome by Elsenbruch, Sigrid, Hahn, Susanne, Kowalsky, Daniela, Öffner, Alexandra H., Schedlowski, Manfred, Mann, Klaus, Janssen, Onno E.

“…Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic anovulation and hyperandrogenism. PCOS is one of the leading causes of…”
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Progesterone treatment reduces disease severity and increases IL-10 in experimental autoimmune encephalomyelitis by Yates, M.A, Li, Y, Chlebeck, P, Proctor, T, Vandenbark, A.A, Offner, H

“…Abstract Ovarian hormones, including progesterone, are known to have immunomodulatory and neuroprotective effects which may alter the disease course of…”
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High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome by Janssen, OE, Mehlmauer, N, Hahn, S, Offner, AH, Gartner, R

“…OBJECTIVE: To investigate the prevalence of autoimmune thyroiditis (AIT) in patients with polycystic ovary syndrome (PCOS). DESIGN: Over a period of 30 months,…”
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Recombinant T-cell receptor ligand RTL1000 limits inflammation and decreases infarct size after experimental ischemic stroke in middle-aged mice by Zhu, W, Dotson, A.L, Libal, N.L, Lapato, A.S, Bodhankar, S, Offner, H, Alkayed, N.J

“…Highlights • The effect of immune modulator RTL1000 was tested in humanized transgenic DR2-Tg mice. • RTL1000 reduces infarct size after stroke in 12-month old…”
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Estrogen treatment down-regulates TNF-alpha production and reduces the severity of experimental autoimmune encephalomyelitis in cytokine knockout mice by Ito, A, Bebo, Jr, B F, Matejuk, A, Zamora, A, Silverman, M, Fyfe-Johnson, A, Offner, H

“…A shift toward Th2 cytokine production has been demonstrated during pregnancy and high dose estrogen therapy and is thought to be the primary mechanism by…”
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Low-Dose Estrogen Therapy Ameliorates Experimental Autoimmune Encephalomyelitis in Two Different Inbred Mouse Strains by Bebo, Bruce F., Jr, Fyfe-Johnson, Amber, Adlard, Kirsten, Beam, Aaron G, Vandenbark, Arthur A, Offner, Halina

“…It has been proposed that homeostatic levels of estrogen can enhance female susceptibility to autoimmunity, whereas the heightened levels of estrogen…”
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A new orally bioavailable synthetic androstene inhibits collagen-induced arthritis in the mouse: androstene hormones as regulators of regulatory T cells by Auci, D, Kaler, L, Subramanian, Sandhya, Huang, Yugin, Frincke, J, Reading, C, Offner, H

“…Dehydroepiandrosterone (DHEA) has attracted much interest because of its many antiaging, metabolic and immune-modulating effects in rodents. Synthetic…”
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Single-chain recombinant HLA-DQ2.5 peptide molecules block α2-gliadin-specific pathogenic CD4 T-cell proliferation and attenuate production of inflammatory cytokines: a potential therapy for celiac disease by Huan, J, Meza-Romero, R, Mooney, J L, Vandenbark, A A, Offner, H, Burrows, G G

“…Celiac disease (CD) is a disorder of the small intestine caused by intolerance to wheat gluten and related proteins in barley and rye. CD4 + T cells have a…”
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A New Orally Bioavailable Synthetic Androstene Inhibits Collagen-Induced Arthritis in the Mouse by AUCI, D., KALER, L., SUBRAMANIAN, SANDHYA, HUANG, YUGIN, FRINCKE, J., READING, C., OFFNER, H.

“…:  Dehydroepiandrosterone (DHEA) has attracted much interest because of its many antiaging, metabolic and immune‐modulating effects in rodents. Synthetic…”
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A highly immunogenic trivalent T cell receptor peptide vaccine for multiple sclerosis by Bourdette, D N, Edmonds, E, Smith, C, Bowen, J D, Guttmann, C RG, Nagy, Z P, Simon, J, Whitham, R, Lovera, J, Yadav, V, Mass, M, Spencer, L, Culbertson, N, Bartholomew, R M, Theofan, G, Milano, J, Offner, H, Vandenbark, A A

“…Background: T cell receptor (TCR) peptide vaccination is a novel approach to treating multiple sclerosis (MS). The low immunogenicity of previous vaccines has…”
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Male SJL mice do not relapse after induction of EAE with PLP 139-151 by Bebo Jr, B.F., Vandenbark, A.A., Offner, H.

“…SJL mice immunized with proteolipid protein (PLP) develop relapsing experimental autoimmune encephalomyelitis (R‐EAE). R‐EAE is a CD4+, Th1 cell‐mediated…”
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Selective depletion of myelin-reactive T cells with the anti-OX-40 antibody ameliorates autoimmune encephalomyelitis by Weinberg, A.D, Bourdette, D.N, Sullivan, T.J, Lemon, M, Wallin, J.J, Maziarz, R, Davey, M, Palida, F, Godfrey, W, Engleman, E, Fulton, R.J, Offner, H, Vandenbark, A.A

“…The OX-40 protein was selectively upregulated on encephalitogenic myelin basic protein (MBP)-specific T cells at the site of inflammation during the onset of…”
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T Cell Receptor Peptide Therapy Triggers Autoregulation of Experimental Encephalomyelitis by Offner, Halina, Hashim, George A., Vandenbark, Arthur A.

“…Encephalitogenic T cells specific for myelin basic protein share common V$_\beta$8 peptide sequences in their T cell receptor (TCR) that can induce…”
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Rudimentary TCR Signaling Triggers Default IL-10 Secretion by Human Th1 Cells by Burrows, Gregory G, Chou, Yuan K, Wang, Chunhe, Chang, Justin W, Finn, Thomas P, Culbertson, Nicole E, Kim, Joseph, Bourdette, Dennis N, Lewinsohn, Deborah A, Lewinsohn, David M, Ikeda, Masayuki, Yoshioka, Tohru, Allen, Charles N, Offner, Halina, Vandenbark, Arthur A

“…Understanding the process of inducing T cell activation has been hampered by the complex interactions between APC and inflammatory Th1 cells. To dissociate…”
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Preferential T-Cell Receptor β-Chain Variable Gene Use in Myelin Basic Protein-Reactive T-Cell Clones from Patients with Multiple Sclerosis by Kotzin, Brian L., Karuturi, Satyanarayana, Chou, Yuan K., Lafferty, Joyce, Forrester, Joseph M., Better, Marc, Nedwin, Glenn E., Offner, Halina, Vandenbark, Arthur A.

“…Multiple sclerosis is an autoimmune disease in which T lymphocytes reactive to myelin basic protein (BP) could play a central role. T cells specific for BP…”
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The OX-40 receptor provides a potent co-stimulatory signal capable of inducing encephalitogenicity in myelin-specific CD4+ T cells by Kaleeba, J A, Offner, H, Vandenbark, A A, Lublinski, A, Weinberg, A D

“…The OX-40 receptor, a member of the nerve growth factor/tumor necrosis factor receptor gene family, is expressed preferentially on autoreactive CD4+ T cells…”
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Both rat and mouse T cell receptors specific for the encephalitogenic determinant of myelin basic protein use similar V alpha and V beta chain genes even though the major histocompatibility complex and encephalitogenic determinants being recognized are different by Burns, F R, Li, X B, Shen, N, Offner, H, Chou, Y K, Vandenbark, A A, Heber-Katz, E

“…Prospects for specific immune intervention in T cell-mediated autoimmune disease via anti-idiotypic regulation depend on the degree of diversity of the…”
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