Calcitonin Measurements for Early Detection of Medullary Thyroid Carcinoma or its Premalignant Conditions in Hashimoto's Thyroiditis

The measurement of basal serum calcitonin (CT) in patients with evidence of Hashimoto's thyroiditis (HT) has been proposed in a recent study demonstrating an increased prevalence of elevated basal and stimulated CT. The aim of this study was to evaluate the frequency and relevance of elevated C...

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Published in:	Anticancer research Vol. 26; no. 1B; pp. 723 - 727
Main Authors:	SCHUETZ, Matthias, BEHESHTI, Mohsen, KARANIKAS, Georgios, PIRICH, Christian, OEZER, Semun, NOVOTNY, Clemens, PAUL, Matthias, HOFMANN, Andrea, BIEGLMAYER, Christian, NIEDERLE, Bruno, KLETTER, Kurt, DUDCZAK, Robert
Format:	Journal Article
Language:	English
Published:	Attiki International Institute of Anticancer Research 01-01-2006
Subjects:	Adolescent Adult Aged Aged, 80 and over Biological and medical sciences Calcitonin - blood Carcinoma, Medullary - blood Carcinoma, Medullary - genetics DNA, Neoplasm - blood DNA, Neoplasm - genetics Endocrinopathies Female Hashimoto Disease - blood Hashimoto Disease - genetics Humans Male Malignant tumors Medical sciences Middle Aged Precancerous Conditions - blood Precancerous Conditions - genetics Proto-Oncogene Proteins c-ret - genetics Thyroid Neoplasms - blood Thyroid Neoplasms - genetics Thyroid. Thyroid axis (diseases) Tumors Endocrinopathy Pentagastrin Premalignant lesion pentagastrin stimulation test Hyperplasia Thyroid diseases Autoimmune disease Stimulation C cell hyperplasia Malignant tumor Thyroid carcinoma Hashimoto's thyroiditis Gastrointestinal hormone Thyroid cancer Cancerology Calcitonin Hashimoto thyroiditis Medullary carcinoma Thyroid hormone Diagnosis medullary thyroid carcinoma Pentapeptide
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Summary:	The measurement of basal serum calcitonin (CT) in patients with evidence of Hashimoto's thyroiditis (HT) has been proposed in a recent study demonstrating an increased prevalence of elevated basal and stimulated CT. The aim of this study was to evaluate the frequency and relevance of elevated CT levels in HT. The basal sera CT were measured in 568 consecutive HT patients using a chemiluminescent immuno-assay. Whenever the serum CT was >10 pg/ml, a pentagastrin (PG) stimulation test was performed. Two patients with abnormal/ pathological PG tests were identified. Total thyroidectomy and lymph node dissection revealed for the first patient medullary thyroid carcinoma (MTC) and for the second patient C cell hyperplasia (CCH), together with papillary thyroid carcinoma. Our data showed a low prevalence of MTC and its premalignant condition CCH in HT patients; nevertheless, the patient with MTC presented lymph node metastasis. The fact that both cases presented without evidence of nodular thyroid disease highlights the persistent diagnostic dilemma of CT screening programs.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0250-7005 1791-7530