Search Results - "OETH, Paul"

Noninvasive detection of fetal trisomy 21 by sequencing of DNA in maternal blood: a study in a clinical setting by Ehrich, Mathias, MD, Deciu, Cosmin, MSc, Zwiefelhofer, Tricia, Tynan, John A., DPhil, Cagasan, Lesley, MSc, Tim, Roger, DPhil, Lu, Vivian, McCullough, Ron, DPhil, McCarthy, Erin, Nygren, Anders O.H., DPhil, Dean, Jarrod, Tang, Lin, DPhil, Hutchison, Don, MSc, Lu, Tim, DPhil, Wang, Huiquan, DPhil, Angkachatchai, Vach, DPhil, Oeth, Paul, MSc, Cantor, Charles R., DPhil, Bombard, Allan, MD, van den Boom, Dirk, DPhil

“…Objective We sought to evaluate a multiplexed massively parallel shotgun sequencing assay for noninvasive trisomy 21 detection using circulating cell-free…”
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Detection of fetal subchromosomal abnormalities by sequencing circulating cell-free DNA from maternal plasma by Zhao, Chen, Tynan, John, Ehrich, Mathias, Hannum, Gregory, McCullough, Ron, Saldivar, Juan-Sebastian, Oeth, Paul, van den Boom, Dirk, Deciu, Cosmin

“…The development of sequencing-based noninvasive prenatal testing (NIPT) has been largely focused on whole-chromosome aneuploidies (chromosomes 13, 18, 21, X,…”
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Determination of fetal DNA fraction from the plasma of pregnant women using sequence read counts by Kim, Sung K., Hannum, Gregory, Geis, Jennifer, Tynan, John, Hogg, Grant, Zhao, Chen, Jensen, Taylor J., Mazloom, Amin R., Oeth, Paul, Ehrich, Mathias, van den Boom, Dirk, Deciu, Cosmin

“…Objective This study introduces a novel method, referred to as SeqFF, for estimating the fetal DNA fraction in the plasma of pregnant women and to infer the…”
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Non-invasive prenatal chromosomal aneuploidy testing--clinical experience: 100,000 clinical samples by McCullough, Ron M, Almasri, Eyad A, Guan, Xiaojun, Geis, Jennifer A, Hicks, Susan C, Mazloom, Amin R, Deciu, Cosmin, Oeth, Paul, Bombard, Allan T, Paxton, Bill, Dharajiya, Nilesh, Saldivar, Juan-Sebastian

“…As the first laboratory to offer massively parallel sequencing-based noninvasive prenatal testing (NIPT) for fetal aneuploidies, Sequenom Laboratories has been…”
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Noninvasive prenatal detection of sex chromosomal aneuploidies by sequencing circulating cell-free DNA from maternal plasma by Mazloom, Amin R., Džakula, Željko, Oeth, Paul, Wang, Huiquan, Jensen, Taylor, Tynan, John, McCullough, Ron, Saldivar, Juan-Sebastian, Ehrich, Mathias, van den Boom, Dirk, Bombard, Allan T., Maeder, Margo, McLennan, Graham, Meschino, Wendy, Palomaki, Glenn E., Canick, Jacob A., Deciu, Cosmin

“…ABSTRACT Objective Whole‐genome sequencing of circulating cell free (ccf) DNA from maternal plasma has enabled noninvasive prenatal testing for common…”
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High-throughput massively parallel sequencing for fetal aneuploidy detection from maternal plasma by Jensen, Taylor J, Zwiefelhofer, Tricia, Tim, Roger C, Džakula, Željko, Kim, Sung K, Mazloom, Amin R, Zhu, Zhanyang, Tynan, John, Lu, Tim, McLennan, Graham, Palomaki, Glenn E, Canick, Jacob A, Oeth, Paul, Deciu, Cosmin, van den Boom, Dirk, Ehrich, Mathias

“…Circulating cell-free (ccf) fetal DNA comprises 3-20% of all the cell-free DNA present in maternal plasma. Numerous research and clinical studies have…”
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Role of ICAM1 in invasion of human breast cancer cells by Rosette, Caridad, Roth, Richard B., Oeth, Paul, Braun, Andreas, Kammerer, Stefan, Ekblom, Jonas, Denissenko, Mikhail F.

“…We identified previously a region on chromosome 19p13.2 spanning the genes encoding the intercellular adhesion molecules (ICAM), ICAM1, ICAM4 and ICAM5 as a…”
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Multiplexed analysis of circulating cell-free fetal nucleic acids for noninvasive prenatal diagnostic RHD testing by Tynan, John A., DPhil, Angkachatchai, Vach, DPhil, Ehrich, Mathias, MD, Paladino, Toni, DPhil, van den Boom, Dirk, DPhil, Oeth, Paul, MS

“…Objective The objective of the study was the evaluation of a novel multiplex assay to detect fetal Rh blood group D-antigen gene ( RHD) loci in maternal plasma…”
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Inclusion of Genotype with Fundus Phenotype Improves Accuracy of Predicting Choroidal Neovascularization and Geographic Atrophy by Perlee, Lorah T., PhD, Bansal, Aruna T., PhD, Gehrs, Karen, MD, Heier, Jeffrey S., MD, Csaky, Karl, MD, Allikmets, Rando, PhD, Oeth, Paul, MS, Paladino, Toni, PhD, Farkas, Daniel H., PhD, Rawlings, P. Lyle, BS, Hageman, Gregory S., PhD

“…Purpose The accuracy of predicting conversion from early-stage age-related macular degeneration (AMD) to the advanced stages of choroidal neovascularization…”
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MALDI-TOF mass spectrometry : A versatile tool for high-performance DNA analysis by JURINKE, Christian, OETH, Paul, VAN DEN BOOM, Dirk

“…Matrix-assisted laser desorption/ionization (MALDI) time-of-flight (TOF) mass spectrometry (MS) has developed during the past decade into a versatile tool for…”
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Clinical validation of a genetic model to estimate the risk of developing choroidal neovascular age-related macular degeneration by Hageman, Gregory S, Gehrs, Karen, Lejnine, Serguei, Bansal, Aruna T, Deangelis, Margaret M, Guymer, Robyn H, Baird, Paul N, Allikmets, Rando, Deciu, Cosmin, Oeth, Paul, Perlee, Lorah T

“…Predictive tests for estimating the risk of developing late-stage neovascular age-related macular degeneration (AMD) are subject to unique challenges. AMD…”
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A single nucleotide polymorphism based approach for the identification and characterization of gene expression modulation using MassARRAY by Jurinke, Christian, Denissenko, Mikhail F, Oeth, Paul, Ehrich, Matthias, van den Boom, Dirk, Cantor, Charles R

“…Single nucleotide polymorphisms (SNPs) are the most common form of genetic variation. Their abundance and the ease with which they can be assayed have lead to…”
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Development and evaluation of a PCR and mass spectroscopy (PCR–MS)-based method for quantitative, type-specific detection of human papillomavirus by Patel, Divya A., Shih, Yang-Jen, Newton, Duane W., Michael, Claire W., Oeth, Paul A., Kane, Michael D., Opipari, Anthony W., Ruffin, IV, Mack T., Kalikin, Linda M., Kurnit, David M.

“…Knowledge of the central role of high-risk human papillomavirus (HPV) in cervical carcinogenesis, coupled with an emerging need to monitor the efficacy of…”
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Transcriptional Regulation of the Tissue Factor Gene in Human Epithelial Cells Is Mediated by Sp1 and EGR-1 () by Cui, Mei-Zhen, Parry, Graham C.N., Oeth, Paul, Larson, Heike, Smith, Melissa, Huang, Ruo-Pan, Adamson, Eileen D., Mackman, Nigel

“…Tissue factor (TF) gene expression is rapidly induced in epithelial cells by phorbol 12-myristate 13-acetate and serum. We have shown that this induction is…”
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Quantitative mutant analysis of viral quasispecies by chip-based matrix-assisted laser desorption/ ionization time-of-flight mass spectrometry by Amexis, G, Oeth, P, Abel, K, Ivshina, A, Pelloquin, F, Cantor, C R, Braun, A, Chumakov, K, Brau, A

“…RNA viruses exist as quasispecies, heterogeneous and dynamic mixtures of mutants having one or more consensus sequences. An adequate description of the genomic…”
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Transcript profiling of candidate genes in testis of pigs exhibiting large differences in androstenone levels by Grindflek, Eli, Berget, Ingunn, Moe, Maren, Oeth, Paul, Lien, Sigbjørn

“…Boar taint is an unpleasant odor and flavor of the meat and occurs in a high proportion of uncastrated male pigs. Androstenone, a steroid produced in testis…”
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Factors affecting levels of circulating cell-free fetal DNA in maternal plasma and their implications for noninvasive prenatal testing by Kinnings, Sarah L., Geis, Jennifer A., Almasri, Eyad, Wang, Huiquan, Guan, Xiaojun, McCullough, Ron M., Bombard, Allan T., Saldivar, Juan-Sebastian, Oeth, Paul, Deciu, Cosmin

“…What's already known about this topic? Sufficient fetal‐to‐total DNA fraction (‘fetal fraction’) of a maternal plasma sample is required for accurate…”
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The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant by Douglas, Julie A., Erdos, Michael R., Watanabe, Richard M., Braun, Andi, Johnston, Cristy L., Oeth, Paul, Mohlke, Karen L., Valle, Timo T., Ehnholm, Christian, Buchanan, Thomas A., Bergman, Richard N., Collins, Francis S., Boehnke, Michael, Tuomilehto, Jaakko

“…The Peroxisome Poliferator–Activated Receptor-γ2 Pro12Ala Variant Association With Type 2 Diabetes and Trait Differences Julie A. Douglas 1 , Michael R. Erdos…”
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87: Noninvasive prenatal testing: 100,000 patients–clinical impact by McCullough, Ron, Almasri, Eyad, Guan, Xiaojun, Oeth, Paul, Bombard, Allan, Saldivar, Juan-Sebastian

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Fetal RHD genotype detection from circulating cell-free fetal DNA in maternal plasma in non-sensitized RhD negative women by Bombard, Allan T., Akolekar, Ranjit, Farkas, Daniel H., VanAgtmael, Anna L., Aquino, Frank, Oeth, Paul, Nicolaides, Kypros H.

“…Objective To examine the performance of the SensiGene Fetal RHD Genotyping Laboratory Developed Test (RHD Genotyping LDT) using circulating cell‐free fetal DNA…”
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