Search Results - "OEI, ARLENE L"
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Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all
Published in Radiation oncology (London, England) (07-08-2015)“…The currently available arsenal of anticancer modalities includes many DNA damaging agents that can kill malignant cells. However, efficient DNA repair…”
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ASO Author Reflections: Personalized Breast Cancer Treatment Using Preoperative Partial Breast Irradiation
Published in Annals of surgical oncology (01-09-2023)Get full text
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Variation in Clinical Application of Hyperthermic Intraperitoneal Chemotherapy: A Review
Published in Cancers (11-01-2019)“…Peritoneal metastasis (PM) originating from gastrointestinal and gynecological malignancies are associated with a poor prognosis and rapid disease progression…”
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Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis
Published in Cancer research (Chicago, Ill.) (01-12-2015)“…Human papillomavirus (HPV) is associated with cervical cancer, the third most common cancer in women. The high-risk HPV types 16 and 18 are found in over 70%…”
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Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer
Published in International journal of hyperthermia (29-11-2019)“…Purpose: Enhancing immune responses in triple negative breast cancers (TNBCs) remains a challenge. Our study aimed to determine whether magnetic iron oxide…”
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Genetic markers of late radiation toxicity in the era of image-guided radiotherapy: lower toxicity rates reduce the predictive value of γ-H2AX foci decay ratio in patients undergoing pelvic radiotherapy
Published in Radiation oncology (London, England) (02-09-2024)“…A predictive assay for late radiation toxicity would allow more personalized treatment planning, reducing the burden of toxicity for the more sensitive…”
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Cell survival and radiosensitisation: Modulation of the linear and quadratic parameters of the LQ model
Published in International journal of oncology (01-05-2013)“…The linear-quadratic model (LQ model) provides a biologically plausible and experimentally established method to quantitatively describe the dose-response to…”
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Application of HIPEC simulations for optimizing treatment delivery strategies
Published in International journal of hyperthermia (31-12-2023)“…Hyperthermic IntraPEritoneal Chemotherapy (HIPEC) aims to treat microscopic disease left after CytoReductive Surgery (CRS). Thermal enhancement depends on the…”
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A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer
Published in Radiation oncology (London, England) (27-04-2017)“…Combined radiotherapy and hyperthermia is a well-established alternative to chemoradiotherapy for advanced stage cervical cancer patients with a…”
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Simulating drug penetration during hyperthermic intraperitoneal chemotherapy
Published in Drug delivery (01-12-2021)“…Hyperthermic intraperitoneal chemotherapy (HIPEC) is administered to treat residual microscopic disease after debulking cytoreductive surgery. During HIPEC, a…”
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Prediction of pathologic complete response after single-dose MR-guided partial breast irradiation in low-risk breast cancer patients: the ABLATIVE-2 trial-a study protocol
Published in BMC cancer (09-05-2023)“…Partial breast irradiation (PBI) is standard of care in low-risk breast cancer patients after breast-conserving surgery (BCS). Pre-operative PBI can result in…”
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Demonstration of treatment planning software for hyperthermic intraperitoneal chemotherapy in a rat model
Published in International journal of hyperthermia (01-01-2021)“…Hyperthermic intraperitoneal chemotherapy (HIPEC) is administered to treat residual microscopic disease after cytoreductive surgery (CRS). During HIPEC, fluid…”
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The Impact of the Time Interval Between Radiation and Hyperthermia on Clinical Outcome in Patients With Locally Advanced Cervical Cancer
Published in Frontiers in oncology (21-05-2019)Get full text
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HyCHEED System for Maintaining Stable Temperature Control during Preclinical Irreversible Electroporation Experiments at Clinically Relevant Temperature and Pulse Settings
Published in Sensors (Basel, Switzerland) (31-10-2020)“…Electric permeabilization of cell membranes is the main mechanism of irreversible electroporation (IRE), an ablation technique for treatment of unresectable…”
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Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia
Published in International journal of hyperthermia (01-01-2019)“…Purpose: A proposed mechanism for the enhanced effectiveness of hyperthermia and doxorubicin (Dox) combinations is increased intracellular Dox concentrations…”
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The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines
Published in Cells (Basel, Switzerland) (25-07-2020)“…Cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal chemotherapy (HIPEC) is a treatment with curative intent for peritoneal metastasis of…”
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Elevated temperatures and longer durations improve the efficacy of oxaliplatin- and mitomycin C-based hyperthermic intraperitoneal chemotherapy in a confirmed rat model for peritoneal metastasis of colorectal cancer origin
Published in Frontiers in oncology (16-03-2023)“…In patients with limited peritoneal metastasis (PM) originating from colorectal cancer, cytoreductive surgery (CRS) followed by hyperthermic intraperitoneal…”
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Enhancement of Radiation Effectiveness in Cervical Cancer Cells by Combining Ionizing Radiation with Hyperthermia and Molecular Targeting Agents
Published in International journal of molecular sciences (16-08-2018)“…Hyperthermia (HT) and molecular targeting agents can be used to enhance the effect of radiotherapy (RT). The purpose of this paper is to evaluate radiation…”
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Validation of thermal dynamics during Hyperthermic IntraPEritoneal Chemotherapy simulations using a 3D-printed phantom
Published in Frontiers in oncology (14-02-2023)“…CytoReductive Surgery (CRS) followed by Hyperthermic IntraPeritoneal Chemotherapy (HIPEC) is an often used strategy in treating patients diagnosed with…”
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