Search Results - "OBIKHOD, Aleksandr"

Simultaneous Quantification of Intracellular Natural and Antiretroviral Nucleosides and Nucleotides by Liquid Chromatography−Tandem Mass Spectrometry by Fromentin, Emilie, Gavegnano, Christina, Obikhod, Aleksandr, Schinazi, Raymond F

“…Nucleoside reverse transcriptase inhibitors (NRTI) require intracellular phosphorylation, which involves multiple enzymatic steps to inhibit the human…”
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Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse Transcriptase by Tchesnokov, Egor P., Obikhod, Aleksandr, Schinazi, Raymond F., Gótte, Matthias

“…Entecavir (ETV) is a potent antiviral nucleoside analogue that is used to treat hepatitis B virus (HBV) infection. Recent clinical studies have demonstrated…”
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Mechanism of Activation of β-d-2′-Deoxy-2′-Fluoro-2′-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase by MURAKAMI, Eisuke, HAIYING BAO, FURMAN, Phillip A, RAMESH, Mangala, MCBRAYER, Tamara R, WHITAKER, Tony, MICOLOCHICK STEUER, Holly M, SCHINAZI, Raymond F, STUYVER, Lieven J, OBIKHOD, Aleksandr, OTTO, Michael J

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Evaluation of Single and Combination Therapies with Tenofovir Disoproxil Fumarate and Emtricitabine In Vitro and in a Robust Mouse Model Supporting High Levels of Hepatitis B Virus Replication by SCHINAZI, Raymond F, BASSIT, Leda, CLAYTON, Marcia M, SUN, Bill, KOHLER, James J, OBIKHOD, Aleksandr, ARZUMANYAN, Alla, FEITELSON, Mark A

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Engineering of a Chimeric RB69 DNA Polymerase Sensitive to Drugs Targeting the Cytomegalovirus Enzyme by Tchesnokov, Egor P., Obikhod, Aleksandr, Schinazi, Raymond F., Götte, Matthias

“…Detailed structural and biochemical studies with the human cytomegalovirus (HCMV UL54) DNA polymerase are hampered by difficulties to obtain this enzyme in…”
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Mechanisms Associated with HIV-1 Resistance to Acyclovir by the V75I Mutation in Reverse Transcriptase by Tchesnokov, Egor P., Obikhod, Aleksandr, Massud, Ivana, Lisco, Andrea, Vanpouille, Christophe, Brichacek, Beda, Balzarini, Jan, McGuigan, Christopher, Derudas, Marco, Margolis, Leonid, Schinazi, Raymond F., Götte, Matthias

“…It has recently been demonstrated that the anti-herpetic drug acyclovir (ACV) also displays antiviral activity against the human immunodeficiency virus type 1…”
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Simultaneous quantification of 9-(β- d-1,3-dioxolan-4-yl)guanine, Amdoxovir and Zidovudine in human plasma by liquid chromatography–tandem mass spectrometric assay by Fromentin, Emilie, Asif, Ghazia, Obikhod, Aleksandr, Hurwitz, Selwyn J., Schinazi, Raymond F.

“…A sensitive method was developed and validated for simultaneous measurement of an investigational antiviral nucleoside, Amdoxovir (DAPD), its deaminated…”
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Pharmacokinetics of the Anti-Human Immunodeficiency Virus Agent 1-(β-d-Dioxolane)Thymine in Rhesus Monkeys by ASIF, Ghazia, HURWITZ, Selwyn J, OBIKHOD, Aleksandr, DELINSKY, David, NARAYANASAMY, Janarthanan, CHU, Chung K, MCCLURE, Harold M, SCHINAZI, Raymond F

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Cellular Pharmacology of 9-(β-D-1,3-dioxolan-4-yl) Guanine and its Lack of Drug Interactions with Zidovudine in Primary Human Lymphocytes by Hernandez-Santiago, Brenda I, Obikhod, Aleksandr, Fromentin, Emilie, Hurwitz, Selwyn J, Schinazi, Raymond F

“…Amdoxovir, currently in Phase II clinical trials, is rapidly converted to 9-(β-D-1,3-dioxolan-4-yl)guanine (DXG) by adenosine deaminase in vitro and in humans…”
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Phosphorodiamidates as a Promising New Phosphate Prodrug Motif for Antiviral Drug Discovery: Application to Anti-HCV Agents by McGuigan, Christopher, Madela, Karolina, Aljarah, Mohamed, Bourdin, Claire, Arrica, Maria, Barrett, Emma, Jones, Sarah, Kolykhalov, Alexander, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Gorovits, Elena, Henson, Geoffrey, Hunley, Damound, Hutchins, Jeff, Muhammad, Jerry, Obikhod, Aleksandr, Patti, Joseph, Walters, C. Robin, Wang, Jin, Vernachio, John, Ramamurty, Changalvala V. S, Battina, Srinivas K, Chamberlain, Stanley

“…We herein report phosphorodiamidates as a significant new phosphate prodrug motif. Sixty-seven phosphorodiamidates are reported of two 6-O-alkyl 2′-C-methyl…”
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Delayed Chain Termination Protects the Anti-hepatitis B Virus Drug Entecavir from Excision by HIV-1 Reverse TranscriptaseS by Tchesnokov, Egor P., Obikhod, Aleksandr, Schinazi, Raymond F., Götte, Matthias

“…Entecavir (ETV) is a potent antiviral nucleoside analogue that is used to treat hepatitis B virus (HBV) infection. Recent clinical studies have demonstrated…”
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Synthesis, antiviral activity, cytotoxicity and cellular pharmacology of l-3′-azido-2′,3′-dideoxypurine nucleosides by Zhang, Hong-wang, Detorio, Mervi, Herman, Brian D., Solomon, Sarah, Bassit, Leda, Nettles, James H., Obikhod, Aleksandr, Tao, Si-jia, Mellors, John W., Sluis-Cremer, Nicolas, Coats, Steven J., Schinazi, Raymond F.

“…Microwave-assisted optimized transglycosylation reactions were used to prepare eleven modified l-3′-azido-2′,3′-dideoxypurine nucleosides. These l-nucleoside…”
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Synthesis and evaluation against hepatitis C virus of 7-deaza analogues of 2′-C-methyl-6-O-methyl guanosine nucleoside and l-Alanine ester phosphoramidates by Bourdin, Claire, McGuigan, Christopher, Brancale, Andrea, Chamberlain, Stanley, Vernachio, John, Hutchins, Jeff, Gorovits, Elena, Kolykhalov, Alexander, Muhammad, Jerry, Patti, Joseph, Henson, Geoffrey, Bleiman, Blair, Bryant, K. Dawn, Ganguly, Babita, Hunley, Damound, Obikhod, Aleksandr, Walters, C. Robin, Wang, Jin, Ramamurty, Changalvala V.S., Battina, Srinivas K., Srivinas Rao, C.

“…7-Deazapurines are known to possess broad antiviral activity, however the 2′-C-methylguanosine analogue displays poor cell permeation and limited…”
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Substrate mimicry: HIV-1 reverse transcriptase recognizes 6-modified-3′-azido-2′,3′-dideoxyguanosine-5′-triphosphates as adenosine analogs by Herman, Brian D., Schinazi, Raymond F., Zhang, Hong-wang, Nettles, James H., Stanton, Richard, Detorio, Mervi, Obikhod, Aleksandr, Pradère, Ugo, Coats, Steven J., Mellors, John W., Sluis-Cremer, Nicolas

“…β-D-3′-Azido-2′,3′-dideoxyguanosine (3′-azido-ddG) is a potent inhibitor of HIV-1 replication with a superior resistance profile to zidovudine. Recently, we…”
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Synthesis and evaluation of 3′-azido-2′,3′-dideoxypurine nucleosides as inhibitors of human immunodeficiency virus by Zhang, Hong-wang, Coats, Steven J., Bondada, Lavanya, Amblard, Franck, Detorio, Mervi, Asif, Ghazia, Fromentin, Emilie, Solomon, Sarah, Obikhod, Aleksandr, Whitaker, Tony, Sluis-Cremer, Nicolas, Mellors, John W., Schinazi, Raymond F.

“…A series of purine modified 3′-azido nucleosides were synthesized by a chemical transglycosylation reaction and evaluated for their anti-HIV-1 activity,…”
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Synthesis and Anti-HIV Evaluation of 3′-Triazolo Nucleosides by Roy, Vincent, Obikhod, Aleksandr, Zhang, Hong-Wang, Coats, Steven J., Herman, Brian D., Sluis-Cremer, Nicolas, Agrofoglio, Luigi A., Schinazi, Raymond F.

“…A series of hitherto unknown 3′-α-[1,2,3]-substituted triazolo-2′,3′-dideoxypyrimidine nucleoside analogues of the anti-HIV 3′-azido-3′-deoxythymidine (AZT)…”
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Telbivudine exerts no antiviral activity against HIV-1 in vitro and in humans by van Maarseveen, Noortje M, Wensing, Annemarie Mj, de Jong, Dorien, Beilhartz, Greg L, Obikhod, Aleksandr, Tao, Sijia, Pingen, Marieke, Arends, Joop E, Hoepelman, Andy Im, Schinazi, Raymond F, Götte, Matthias, Nijhuis, Monique

“…HIV-HBV-coinfected individuals who need to be treated only for their HBV infection have limited therapeutic options, since most approved anti-HBV agents have a…”
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Mechanism of Activation of {szligbeta}-D-2'-Deoxy-2'-Fluoro-2'-C-Methylcytidine and Inhibition of Hepatitis C Virus NS5B RNA Polymerase by Murakami, Eisuke, Bao, Haiying, Ramesh, Mangala, McBrayer, Tamara R, Whitaker, Tony, Micolochick Steuer, Holly M, Schinazi, Raymond F, Stuyver, Lieven J, Obikhod, Aleksandr, Otto, Michael J, Furman, Phillip A

“…{szligbeta}-D-2'-Deoxy-2'-fluoro-2'-C-methylcytidine (PSI-6130) is a potent specific inhibitor of hepatitis C virus (HCV) RNA synthesis in Huh-7 replicon…”
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Short communication cellular pharmacology of 9-(beta-D-1,3-dioxolan-4-yl) guanine and its lack of drug interactions with zidovudine in primary human lymphocytes by Hernandez-Santiago, Brenda I, Obikhod, Aleksandr, Fromentin, Emilie, Hurwitz, Selwyn J, Schinazi, Raymond F

“…Amdoxovir, currently in Phase II clinical trials, is rapidly converted to 9-(beta-D-1,3-dioxolan-4-yl)guanine (DXG) by adenosine deaminase in vitro and in…”
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