Search Results - "OBERMILLER, P. S"

Decreased expression of BRCA1 accelerates growth and is often present during sporadic breast cancer progression by Thompson, Marilyn E, Jensen, Roy A, Obermiller, Patrice S, Page, David L, Holt, Jeffrey T

“…We have characterized expression of the familial breast and ovarian cancer gene, BRCA1, in cases of non-hereditary (sporadic) breast cancer and analyzed the…”
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Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes by UCKER, D. S, OBERMILLER, P. S, ECKHART, W, APGAR, J. R, BERGER, N. A, MEYERS, J

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A phase I trial of retroviral BRCA1sv gene therapy in ovarian cancer by TAIT, D. L, OBERMILLER, P. S, REDLIN-FRAZIER, S, JENSEN, R. A, WELCSH, P, DANN, J, KING, M.-C, JOHNSON, D. H, HOLT, J. T

“…Gene transfer of BRCA1sv (a normal splice variant of BRCA1) into ovarian cancer cells produces growth inhibition in vitro and tumor suppression in nude mouse…”
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Ovarian Cancer BRCA1 Gene Therapy: Phase I and II Trial Differences in Immune Response and Vector Stability by TAIT, D. L, OBERMILLER, P. S, HATMAKER, A. R, REDLIN-FRAZIER, S, HOLT, J. T

“…Gene therapy with viral vectors has shown some promise in nude mice models and in initial Phase I trials of patients with extensive metastatic cancer. A Phase…”
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Activation-driven T cell death. II. Quantitative differences alone distinguish stimuli triggering nontransformed T cell proliferation or death by Ucker, DS, Meyers, J, Obermiller, PS

“…Clonal deletion is the major mechanism by which T cell tolerance is achieved in vivo. The process of activation-driven cell death, originally characterized…”
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Ovarian cancer gene therapy by Tait, D L, Obermiller, P S, Jensen, R A, Holt, J T

“…Retroviral-mediated delivery of BRCA1 gene therapy (LXN-BRCA1sv, a normal splice variant form of BRCA1) was tested extensively in mouse models. It was found to…”
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Analysis of substrate specificity of the PaeR7 endonuclease : effect of base methylation on the kinetics of cleavage by GHOSH, S. S, OBERMILLER, P. S, KWOH, T. J, GINGERAS, T. R

“…In murine cells expressing the PaeR7 endonuclease and methylase genes, the recognition sites (CTCGAG) of these enzymes can be methylated at the adenine residue…”
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Preclinical Studies of a New Generation Retroviral Vector for Ovarian Cancer BRCA1 Gene Therapy by Tait, David L., Obermiller, Patrice S., Holt, Jeffrey T.

“…Objective. The aim of this study was to determine the preclinical stability, toxicity, and efficacy of a second-generation complement-resistant retroviral…”
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Gene therapy for carcinoma of the breast: Therapeutic genetic correction strategies by Obermiller, P S, Tait, D L, Holt, J T

“…Gene therapy is a therapeutic approach that is designed to correct specific molecular defects that contribute to the cause or progression of cancer. Genes that…”
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Introduction and expression of the bacterial PaeR7 restriction endonuclease gene in mouse cells containing the PaeR7 methylase by Kwoh, T J, Obermiller, P S, McCue, A W, Kwoh, D Y, Sullivan, S A, Gingeras, T R

“…To study the factors essential for a functional restriction system, the PaeR7 restriction-modification system has been introduced and expressed in murine…”
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Introduction and expression of the bacterial PaeaR7 restriction endonuclease gene in mouse cells containing the PaeR7 methylase by KWOH, T. J, OBERMILLER, P. S, MCCUE, A. W, KWOH, D. Y, SULLIVAN, S. A, GINGERAS, T. R

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