Search Results - "OBATA, Yuichi"

Distinct Neural Circuits for the Formation and Retrieval of Episodic Memories by Roy, Dheeraj S., Kitamura, Takashi, Okuyama, Teruhiro, Ogawa, Sachie K., Sun, Chen, Obata, Yuichi, Yoshiki, Atsushi, Tonegawa, Susumu

“…The formation and retrieval of a memory is thought to be accomplished by activation and reactivation, respectively, of the memory-holding cells (engram cells)…”
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Cell type–specific genetic and optogenetic tools reveal hippocampal CA2 circuits by Kohara, Keigo, Pignatelli, Michele, Rivest, Alexander J, Jung, Hae-Yoon, Kitamura, Takashi, Suh, Junghyup, Frank, Dominic, Kajikawa, Koichiro, Mise, Nathan, Obata, Yuichi, Wickersham, Ian R, Tonegawa, Susumu

“…The authors use cell type–specific transgenic mouse lines, optogenetics and patch-clamp recordings to provide new insights into hippocampal anatomy and…”
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Induction of Cardiomyocyte-Like Cells in Infarct Hearts by Gene Transfer of Gata4, Mef2c, and Tbx5 by Inagawa, Kohei, Miyamoto, Kazutaka, Yamakawa, Hiroyuki, Muraoka, Naoto, Sadahiro, Taketaro, Umei, Tomohiko, Wada, Rie, Katsumata, Yoshinori, Kaneda, Ruri, Nakade, Koji, Kurihara, Chitose, Obata, Yuichi, Miyake, Koichi, Fukuda, Keiichi, Ieda, Masaki

“…RATIONALE:After myocardial infarction (MI), massive cell death in the myocardium initiates fibrosis and scar formation, leading to heart failure. We recently…”
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MoG+: a database of genomic variations across three mouse subspecies for biomedical research by Takada, Toyoyuki, Fukuta, Kentaro, Usuda, Daiki, Kushida, Tatsuya, Kondo, Shinji, Kawamoto, Shoko, Yoshiki, Atsushi, Obata, Yuichi, Fujiyama, Asao, Toyoda, Atsushi, Noguchi, Hideki, Shiroishi, Toshihiko, Masuya, Hiroshi

“…Laboratory mouse strains have mosaic genomes derived from at least three major subspecies that are distributed in Eurasia. Here, we describe genomic variations…”
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Mouse resources at the RIKEN BioResource Research Center and the National BioResource Project core facility in Japan by Mizuno-Iijima, Saori, Nakashiba, Toshiaki, Ayabe, Shinya, Nakata, Hatsumi, Ike, Fumio, Hiraiwa, Noriko, Mochida, Keiji, Ogura, Atsuo, Masuya, Hiroshi, Kawamoto, Shoko, Tamura, Masaru, Obata, Yuichi, Shiroishi, Toshihiko, Yoshiki, Atsushi

“…The RIKEN BioResource Research Center (BRC) was established in 2001 as a comprehensive biological resource center in Japan. The Experimental Animal Division,…”
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Efficient production of large deletion and gene fragment knock-in mice mediated by genome editing with Cas9-mouse Cdt1 in mouse zygotes by Mizuno-Iijima, Saori, Ayabe, Shinya, Kato, Kanako, Matoba, Shogo, Ikeda, Yoshihisa, Dinh, Tra Thi Huong, Le, Hoai Thu, Suzuki, Hayate, Nakashima, Kenichi, Hasegawa, Yoshikazu, Hamada, Yuko, Tanimoto, Yoko, Daitoku, Yoko, Iki, Natsumi, Ishida, Miyuki, Ibrahim, Elzeftawy Abdelaziz Elsayed, Nakashiba, Toshiaki, Hamada, Michito, Murata, Kazuya, Miwa, Yoshihiro, Okada-Iwabu, Miki, Iwabu, Masato, Yagami, Ken-ichi, Ogura, Atsuo, Obata, Yuichi, Takahashi, Satoru, Mizuno, Seiya, Yoshiki, Atsushi, Sugiyama, Fumihiro

“…•Novel CRISPR-Cas vectors with a Cas9 fused to a part of mouse Cdt1.•Nuclear localisation of Cdt1-fused Cas9 in mammalian cells and embryos.•High efficiency in…”
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Distribution of artificial radionuclides in abandoned cattle in the evacuation zone of the Fukushima Daiichi nuclear power plant by Fukuda, Tomokazu, Kino, Yasushi, Abe, Yasuyuki, Yamashiro, Hideaki, Kuwahara, Yoshikazu, Nihei, Hidekazu, Sano, Yosuke, Irisawa, Ayumi, Shimura, Tsutomu, Fukumoto, Motoi, Shinoda, Hisashi, Obata, Yuichi, Saigusa, Shin, Sekine, Tsutomu, Isogai, Emiko, Fukumoto, Manabu

“…The Fukushima Daiichi Nuclear Power Plant (FNPP) accident released large amounts of radioactive substances into the environment. In order to provide basic…”
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The ancestor of extant Japanese fancy mice contributed to the mosaic genomes of classical inbred strains by Takada, Toyoyuki, Ebata, Toshinobu, Noguchi, Hideki, Keane, Thomas M, Adams, David J, Narita, Takanori, Shin-I, Tadasu, Fujisawa, Hironori, Toyoda, Atsushi, Abe, Kuniya, Obata, Yuichi, Sakaki, Yoshiyuki, Moriwaki, Kazuo, Fujiyama, Asao, Kohara, Yuji, Shiroishi, Toshihiko

“…Commonly used classical inbred mouse strains have mosaic genomes with sequences from different subspecific origins. Their genomes are derived predominantly…”
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Genetic Differences among C57BL/6 Substrains by MEKADA, Kazuyuki, ABE, Kuniya, MURAKAMI, Ayumi, NAKAMURA, Satoe, NAKATA, Hatsumi, MORIWAKI, Kazuo, OBATA, Yuichi, YOSHIKI, Atsushi

“…The C57BL/6 mouse is the most well-known inbred mouse strain, and has been widely used as a genetic background for congenic and mutant mice. A number of…”
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NF-κB RELA-deficient bone marrow macrophages fail to support bone formation and to maintain the hematopoietic niche after lethal irradiation and stem cell transplantation by Mise-Omata, Setsuko, Alles, Neil, Fukazawa, Taro, Aoki, Kazuhiro, Ohya, Keiichi, Jimi, Eijiro, Obata, Yuichi, Doi, Takahiro

“…Bone remodeling and hematopoiesis are interrelated and bone marrow (BM) macrophages are considered to be important for both bone remodeling and maintenance of…”
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Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters by Hasegawa, Naoyuki, Abei, Masato, Yokoyama, Kazunari K., Fukuda, Kuniaki, Seo, Emiko, Kawashima, Rei, Nakano, Yuri, Yamada, Takeshi, Nakade, Koji, Hamada, Hirofumi, Obata, Yuichi, Hyodo, Ichinosuke

“…Oncolytic viruses (OVs) are novel cancer therapeutics with great promise, but host antiviral immunity represents the hurdle for their efficacy…”
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High osmolality vitrification: a new method for the simple and temperature-permissive cryopreservation of mouse embryos by Mochida, Keiji, Hasegawa, Ayumi, Li, Ming-Wen, Fray, Martin D, Kito, Seiji, Vallelunga, Jadine M, Lloyd, K C Kent, Yoshiki, Atsushi, Obata, Yuichi, Ogura, Atsuo

“…Procedures for cryopreserving embryos vary considerably, each having its specific advantages and disadvantages in terms of technical feasibility, embryo…”
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Spermatozoa and Spermatids Retrieved from Frozen Reproductive Organs or Frozen Whole Bodies of Male Mice Can Produce Normal Offspring by Ogonuki, Narumi, Mochida, Keiji, Miki, Hiromi, Inoue, Kimiko, Fray, Martin, Iwaki, Takamasa, Moriwaki, Kazuo, Obata, Yuichi, Morozumi, Kazuto, Yanagimachi, Ryuzo, Ogura, Atsuo

“…Cryopreservation of male germ cells is a strategy to conserve animal species and strains of animals valuable to biomedical research. We tested whether mouse…”
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EpCAM‐ and EGFR‐targeted selective gene therapy for biliary cancers using Z33‐fiber‐modified adenovirus by Kawashima, Rei, Abei, Masato, Fukuda, Kuniaki, Nakamura, Kiminori, Murata, Takehide, Wakayama, Mariko, Seo, Emiko, Hasegawa, Naoyuki, Mizuguchi, Hiroyuki, Obata, Yuichi, Hyodo, Ichinosuke, Hamada, Hirofumi, Yokoyama, Kazunari K.

“…A critical issue in adenovirus (Ad)‐based cancer gene therapy is to improve the specificity of gene delivery to cancer cells for better efficacy and safety. We…”
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An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes by Kurihara, Chitose, Nakade, Koji, Pan, Jianzhi, Huang, Jing, Wasylyk, Bohdan, Obata, Yuichi

“…•We generated Cre-loxP-regulated fluorescent universal adenoviral vector system.•The replication of recombinant virus produced by this system is easy to be…”
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Absence of Tumor Necrosis Factor Rescues RelA-Deficient Mice from Embryonic Lethality by Doi, Takahiro S., Marino, Michael W., Takahashi, Toshitada, Yoshida, Toshimichi, Sakakura, Teruyo, Old, Lloyd J., Obata, Yuichi

“…Mice lacking the RelA (p65) subunit of NF-κ B die between days 14 and 15 of embryogenesis because of massive liver destruction. Fibroblasts and macrophages…”
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Generation of cloned calves and transgenic chimeric embryos from bovine embryonic stem-like cells by Saito, Shigeo, Sawai, Ken, Ugai, Hideyo, Moriyasu, Satoru, Minamihashi, Akira, Yamamoto, Yusuke, Hirayama, Hiroki, Kageyama, Soichi, Pan, Jianzhi, Murata, Takehide, Kobayashi, Yoshiro, Obata, Yuichi, Yokoyama, Kazunari K

“…Bovine embryonic stem-like cells (ES-like cells) appear to maintain a normal diploid karyotype indefinitely during culture in vitro and to express marker…”
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Expression of cancer/testis (CT) antigens in lung cancer by Tajima, Kouhei, Obata, Yuichi, Tamaki, Hiromi, Yoshida, Masahiro, Chen, Yao-Tseng, Scanlan, Matthew J, Old, Lloyd J, Kuwano, Hiroyuki, Takahashi, Takashi, Takahashi, Toshitada, Mitsudomi, Tetsuya

“…Cancer/testis (CT) antigens are considered promising candidates for vaccine-based immunotherapy. The aim of this study was to investigate which CT antigens…”
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Immunomic Analysis of Human Sarcoma by Lee, Sang-Yull, Obata, Yuichi, Yoshida, Masahiro, Stockert, Elisabeth, Williamson, Barbara, Jungbluth, Achim A., Chen, Yao-Tseng, Old, Lloyd J., Scanlan, Matthew J.

“…The screening of cDNA expression libraries from human tumors with serum antibody (SEREX) has proven to be a powerful method for identifying the repertoire of…”
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Repression of Bleomycin-Induced Pneumopathy by TNF by Kuroki, Misuzu, Noguchi, Yuji, Shimono, Michihide, Tomono, Kazunori, Tashiro, Takayoshi, Obata, Yuichi, Nakayama, Eiichi, Kohno, Shigeru

“…Idiopathic pulmonary fibrosis is a chronic inflammatory lung disease with interstitial fibrosis. As a potent proinflammatory cytokine, TNF has been suggested…”
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