INSULIN-LIKE GROWTH FACTOR-1 AFTER ORTHOTOPIC LIVER TRANSPLANTATION IN CHILDREN WITH CONGENITAL AND HEREDITARY DISEASES OF HEPATOBILIARY SYSTEM

The research of total and free insulin-like growth factor-1 (IGF-1) in 53 children with with congenital and hereditary diseases of hepatobiliary system was performed before liver transplantation, a month and a year after liver transplantation. Data of our research work revealed reliable decrease of...

Full description

Saved in:

Bibliographic Details
Published in:	Vestnik transplantologii i iskusstvennykh organov Vol. 14; no. 1; pp. 50 - 54
Main Authors:	O.P. Shevchenko, O.M. Tsirulnikova, A.V Bougrov, Y.E. Lourie, I.E. Tsirulnikova, D.S. Mnatsakanyan, O.E. Gichkun, S.V. Gautier
Format:	Journal Article
Language:	Russian
Published:	Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov 01-03-2012
Subjects:	insulin-like growth factor-1, liver cirrhosis, liver transplantation
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	The research of total and free insulin-like growth factor-1 (IGF-1) in 53 children with with congenital and hereditary diseases of hepatobiliary system was performed before liver transplantation, a month and a year after liver transplantation. Data of our research work revealed reliable decrease of total and free IGF-1 serum concentrations in children with liver cirrhosis and controversy increase of PAPP-A, which regulates IGF-1 bioavailability. In a month after orthotopic liver transplantation the level of both fractions of IGF-1 restored. A year later concentrations of total and free IGF-1, and PAPP-A remained at normal rates. Increase of total and free IGF-1 after liver transplantation may contribute to restoration of endocrine regulation of growth, reparative and anabolic processes, and normal physical development of children.
ISSN:	1995-1191
DOI:	10.15825/1995-1191-2012-1-50-54