Search Results - "O. Senge, Mathias"

Molecular Engineering of Free‐Base Porphyrins as Ligands—The N−H⋅⋅⋅X Binding Motif in Tetrapyrroles by Kielmann, Marc, Senge, Mathias O.

“…The core N−H units of planar porphyrins are often inaccessible to forming hydrogen‐bonding complexes with acceptor molecules. This is due to the fact that the…”
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Stirring the porphyrin alphabet soup--functionalization reactions for porphyrins by Senge, Mathias O

“…Advances in the synthesis of unsymmetrically meso substituted porphyrins are based on the development of new total syntheses and porphyrin functionalization…”
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Nonconjugated Hydrocarbons as Rigid‐Linear Motifs: Isosteres for Material Sciences and Bioorganic and Medicinal Chemistry by Locke, Gemma M., Bernhard, Stefan S. R., Senge, Mathias O.

“…Nonconjugated hydrocarbons, like bicyclo[1.1.1]pentane, bicyclo[2.2.2]octane, triptycene, and cubane are a unique class of rigid linkers. Due to their…”
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Cell death in photodynamic therapy: From oxidative stress to anti-tumor immunity by Donohoe, Claire, Senge, Mathias O., Arnaut, Luís G., Gomes-da-Silva, Lígia C.

“…Photodynamic therapy is a promising approach for cancer treatment that relies on the administration of a photosensitizer followed by tumor illumination. The…”
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Conformational control of cofactors in nature - the influence of protein-induced macrocycle distortion on the biological function of tetrapyrroles by Senge, Mathias O, MacGowan, Stuart A, O'Brien, Jessica M

“…Tetrapyrrole-containing proteins are one of the most fundamental classes of enzymes in nature and it remains an open question to give a chemical rationale for…”
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Nucleophilic Aromatic Substitution (SNAr) and Related Reactions of Porphyrinoids: Mechanistic and Regiochemical Aspects by Sample, Harry C., Senge, Mathias O.

“…The nucleophilic substitution of aromatic moieties (SNAr) has been known for over 150 years and found wide use for the functionalization of (hetero)aromatic…”
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Temoporfin (Foscan®, 5,10,15,20-Tetra(m-hydroxyphenyl)chlorin)-A Second-generation Photosensitizer by Senge, Mathias O., Brandt, Johan C.

“…This review traces the development and study of the second‐generation photosensitizer 5,10,15,20‐tetra(m‐hydroxyphenyl)chlorin through to its acceptance and…”
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Generation of Triplet Excited States via Photoinduced Electron Transfer in meso-anthra-BODIPY: Fluorogenic Response toward Singlet Oxygen in Solution and in Vitro by Filatov, Mikhail A, Karuthedath, Safakath, Polestshuk, Pavel M, Savoie, Huguette, Flanagan, Keith J, Sy, Cindy, Sitte, Elisabeth, Telitchko, Maxime, Laquai, Frédéric, Boyle, Ross W, Senge, Mathias O

“…Heavy atom-free BODIPY-anthracene dyads (BADs) generate locally excited triplet states by way of photoinduced electron transfer (PeT), followed by…”
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mTHPC – A drug on its way from second to third generation photosensitizer? by Senge, Mathias O.

“…5,10,15,20-Tetrakis(3-hydroxyphenyl)chlorin (mTHPC, Temoporfin) is a widely investigated second generation photosensitizer. Its initial use in solution form…”
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Extroverted Confusion-Linus Pauling, Melvin Calvin, and Porphyrin Isomers by Senge, Mathias O.

“…Porphyrins may be confused, but Linus Pauling and Melvin Calvin were not! Calvin proposed “carboporphyrins” in 1943 and, unbeknownst to contemporary science,…”
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Ligand-Targeted Delivery of Photosensitizers for Cancer Treatment by Gierlich, Piotr, Mata, Ana I, Donohoe, Claire, Brito, Rui M M, Senge, Mathias O, Gomes-da-Silva, Lígia C

“…Photodynamic therapy (PDT) is a promising cancer treatment which involves a photosensitizer (PS), light at a specific wavelength for PS activation and oxygen,…”
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Nonplanar Porphyrins by N‐Substitution: A Neglected Pathway by Roucan, Marie, Flanagan, Keith J., O'Brien, John, Senge, Mathias O.

“…N‐substitution of porphyrins has been a neglected route towards nonplanar porphyrins for the past decades. Previously, they featured in a host of potential…”
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Self-Organization of Porphyrin–POM Dyads: Nonplanar Diacids and Oxoanions in Low-Dimensional H-Bonding Networks by Kingsbury, Christopher J., Kielmann, Marc, Twamley, Brendan, Senge, Mathias O.

“…Coordinating the spatial arrangement of electroactive partners is crucial to designable molecular electronics and photonics. Porphyrins are ubiquitous reaction…”
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Synthesis and Characterization of Temperature-Sensitive and Chemically Cross-Linked Poly(N‑isopropylacrylamide)/Photosensitizer Hydrogels for Applications in Photodynamic Therapy by Belali, Simin, Savoie, Huguette, O’Brien, Jessica M, Cafolla, Atillio A, O’Connell, Barry, Karimi, Ali Reza, Boyle, Ross W, Senge, Mathias O

“…A novel poly­(N-isopropylacrylamide) (PNIPAM) hydrogel containing different photosensitizers (protoporphyrin IX (PpIX), pheophorbide a (Pba), and…”
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Development of Antimicrobial Laser-Induced Photodynamic Therapy Based on Ethylcellulose/Chitosan Nanocomposite with 5,10,15,20-Tetrakis(m-Hydroxyphenyl)porphyrin by Hasanin, Mohamed S., Abdelraof, Mohamed, Fikry, Mohamed, Shaker, Yasser M., Sweed, Ayman M. K., Senge, Mathias O.

“…The development of new antimicrobial strategies that act more efficiently than traditional antibiotics is becoming a necessity to combat multidrug-resistant…”
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Nanodrug applications in photodynamic therapy by Paszko, Edyta, Ehrhardt, Carsten, Senge, Mathias O., Dr. rer. nat., FTCD, Kelleher, Dermot P, Reynolds, John V

“…Summary Photodynamic therapy (PDT) has developed over last century and is now becoming a more widely used medical tool having gained regulatory approval for…”
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Nucleophilic Substitution as a Tool for the Synthesis of Unsymmetrical Porphyrins by Senge, Mathias O

“…Porphyrins readily undergo SNAr reactions with organolithium reagents, preferentially at the meso-positions. The reaction is highly versatile as it is…”
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Understanding structure–properties relationships of porphyrin linked to graphene oxide through π–π-stacking or covalent amide bonds by Lewandowska-Andralojc, Anna, Gacka, Ewelina, Pedzinski, Tomasz, Burdzinski, Gotard, Lindner, Aleksandra, O’Brien, Jessica M., Senge, Mathias O., Siklitskaya, Aleksandra, Kubas, Adam, Marciniak, Bronislaw, Walkowiak-Kulikowska, Justyna

“…Two graphene oxide nanoassemblies using 5-(4-(aminophenyl)-10,15,20-triphenylporphyrin (TPPNH 2 ) were fabricated by two synthetic methods: covalent…”
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Targeting Receptor Tyrosine Kinase VEGFR-2 in Hepatocellular Cancer: Rational Design, Synthesis and Biological Evaluation of 1,2-Disubstituted Benzimidazoles by Abdel-Mohsen, Heba T, Abdullaziz, Mona A, Kerdawy, Ahmed M El, Ragab, Fatma A F, Flanagan, Keith J, Mahmoud, Abeer E E, Ali, Mamdouh M, Diwani, Hoda I El, Senge, Mathias O

“…In this study, a novel series of 1,2-disubstituted benzo[d]imidazoles was rationally designed as VEGFR-2 inhibitors targeting hepatocellular carcinoma. Our…”
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Cubane Cross‐Coupling and Cubane–Porphyrin Arrays by Bernhard, Stefan S. R., Locke, Gemma M., Plunkett, Shane, Meindl, Alina, Flanagan, Keith J., Senge, Mathias O.

“…Herein, an improved methodology for aryl‐cubane cross‐coupling is reported. The peculiarities of the cubane core and its behavior during cross‐coupling…”
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