Search Results - "O’Sullivan, Jeffrey"
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Novel Facet of an Old Dietary Molecule? Direct Influence of Caffeine on Glucose and Biogenic Amine Handling by Human Adipocytes
Published in Molecules (Basel, Switzerland) (23-06-2021)“…Caffeine is a plant alkaloid present in food and beverages consumed worldwide. It has high lipid solubility with recognized actions in the central nervous…”
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Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation
Published in ACS medicinal chemistry letters (12-11-2020)“…Histone deacetylase inhibitors (HDACi) have emerged as promising therapeutics for the treatment of neurodegeneration, cancer, and rare disorders. Herein, we…”
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Design and synthesis of multifunctional microtubule targeting agents endowed with dual pro-apoptotic and anti-autophagic efficacy
Published in European journal of medicinal chemistry (05-05-2022)“…Autophagy is a lysosome dependent cell survival mechanism and is central to the maintenance of organismal homeostasis in both physiological and pathological…”
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Theobromine and related methylxanthines as inhibitors of Primary Amine Oxidase
Published in Journal of food biochemistry (01-02-2019)“…Methylxanthines are among the most widely consumed drugs in the world and evidence of their health benefits has been growing in recent years. Primary Amine…”
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The inhibition of semicarbazide-sensitive amine oxidase by aminohexoses
Published in Biochimica et biophysica acta (11-04-2003)“…Semicarbazide-sensitive amine oxidase (EC 1.4.3.6; amine:oxygen oxidoreductase (deaminating) (copper-containing); SSAO) is a multifunctional protein. It acts…”
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