Search Results - "O’Shea, Timothy M"

Astrocyte scar formation aids central nervous system axon regeneration by Anderson, Mark A., Burda, Joshua E., Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Kawaguchi, Riki, Coppola, Giovanni, Khakh, Baljit S., Deming, Timothy J., Sofroniew, Michael V.

“…Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely regarded as causal in this failure. Here, using three…”
Get full text

Required growth facilitators propel axon regeneration across complete spinal cord injury by Anderson, Mark A., O’Shea, Timothy M., Burda, Joshua E., Ao, Yan, Barlatey, Sabry L., Bernstein, Alexander M., Kim, Jae H., James, Nicholas D., Rogers, Alexandra, Kato, Brian, Wollenberg, Alexander L., Kawaguchi, Riki, Coppola, Giovanni, Wang, Chen, Deming, Timothy J., He, Zhigang, Courtine, Gregoire, Sofroniew, Michael V.

“…Transected axons fail to regrow across anatomically complete spinal cord injuries (SCI) in adults. Diverse molecules can partially facilitate or attenuate axon…”
Get full text

Divergent transcriptional regulation of astrocyte reactivity across disorders by Burda, Joshua E., O’Shea, Timothy M., Ao, Yan, Suresh, Keshav B., Wang, Shinong, Bernstein, Alexander M., Chandra, Ashu, Deverasetty, Sandeep, Kawaguchi, Riki, Kim, Jae H., McCallum, Sarah, Rogers, Alexandra, Wahane, Shalaka, Sofroniew, Michael V.

“…Astrocytes respond to injury and disease in the central nervous system with reactive changes that influence the outcome of the disorder 1 – 4 . These changes…”
Get full text

Derivation and transcriptional reprogramming of border-forming wound repair astrocytes after spinal cord injury or stroke in mice by O’Shea, Timothy M., Ao, Yan, Wang, Shinong, Ren, Yilong, Cheng, Amy L., Kawaguchi, Riki, Shi, Zechuan, Swarup, Vivek, Sofroniew, Michael V.

“…Central nervous system (CNS) lesions become surrounded by neuroprotective borders of newly proliferated reactive astrocytes; however, fundamental features of…”
Get full text

Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury by Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Burda, Joshua E., Bernstein, Alexander M., Brumm, Andrew J., Muthusamy, Nagendran, Ghashghaei, H. Troy, Carmichael, S. Thomas, Cheng, Liming, Sofroniew, Michael V.

“…Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferated scar-forming astrocytes that protect tissue and function…”
Get full text

An injectable thiol-acrylate poly(ethylene glycol) hydrogel for sustained release of methylprednisolone sodium succinate by Pritchard, Christopher D, O’Shea, Timothy M, Siegwart, Daniel J, Calo, Eliezer, Anderson, Daniel G, Reynolds, Francis M, Thomas, John A, Slotkin, Jonathan R, Woodard, Eric J, Langer, Robert

“…Abstract Clinically available injectable hydrogels face technical challenges associated with swelling after injection and toxicity from unreacted constituents…”
Get full text

Injectable diblock copolypeptide hydrogel provides platform to deliver effective concentrations of paclitaxel to an intracranial xenograft model of glioblastoma by Garrett, Matthew C, O'Shea, Timothy M, Wollenberg, Alexander L, Bernstein, Alexander M, Hung, Derek, Staarman, Brittany, Soto, Horacio, Deming, Timothy J, Sofroniew, Michael V, Kornblum, Harley I

“…Surgical resection and systemic chemotherapy with temozolomide remain the mainstay for treatment of glioblastoma. However, many patients are not candidates for…”
Get full text

Synthesis and Characterization of a Library of In-Situ Curing, Nonswelling Ethoxylated Polyol Thiol-ene Hydrogels for Tailorable Macromolecule Delivery by O'Shea, Timothy M., Aimetti, Alex A., Kim, Eunha, Yesilyurt, Volkan, Langer, Robert

“…A transesterfication reaction is used to synthesize tri‐thiol‐functionalized‐ethoxylated polyols that are combined with polyethylene glycol diacrylates to form…”
Get full text

Evaluation of viscoelastic poly(ethylene glycol) sols as vitreous substitutes in an experimental vitrectomy model in rabbits by Pritchard, Christopher D., Crafoord, Sven, Andréasson, Sten, Arnér, Karin M., O’Shea, Timothy M., Langer, Robert, Ghosh, Fredrik K.

“…The aim of this study was to employ an experimental protocol for in vivo evaluation of sols of 5 wt.% poly(ethylene glycol) (PEG) in phosphate-buffered saline…”
Get full text

Covalent Incorporation of Trehalose within Hydrogels for Enhanced Long-Term Functional Stability and Controlled Release of Biomacromolecules by O'Shea, Timothy M., Webber, Matthew J., Aimetti, Alex A., Langer, Robert

“…Hydrogels with covalently incorporated trehalose are synthesized using thiol‐ene Michael addition. Trehalose hydrogels afford prolonged stabilization and…”
Get full text

Cell biology of spinal cord injury and repair by O'Shea, Timothy M, Burda, Joshua E, Sofroniew, Michael V

“…Spinal cord injury (SCI) lesions present diverse challenges for repair strategies. Anatomically complete injuries require restoration of neural connectivity…”
Get full text

Trehalose-based coacervates for local bioactive protein delivery to the central nervous system by Hassan, Laboni F., Sen, Riya, O'Shea, Timothy M.

“…Therapeutic outcomes of local biomolecule delivery to the central nervous system (CNS) using bulk biomaterials are limited by inadequate drug loading, neuropil…”
Get full text

Ischemic and hemorrhagic stroke lesion environments differentially alter the glia repair potential of neural progenitor cell and immature astrocyte grafts by Adewumi, Honour O., Berniac, Gabriela I., McCarthy, Emily A., O'Shea, Timothy M.

“…Using cell grafting to direct glia-based repair mechanisms in adult CNS injuries represents a potential therapeutic strategy for supporting functional neural…”
Get full text

Foreign body responses in mouse central nervous system mimic natural wound responses and alter biomaterial functions by OʼShea, Timothy M., Wollenberg, Alexander L., Kim, Jae H., Ao, Yan, Deming, Timothy J., Sofroniew, Michael V.

“…Biomaterials hold promise for therapeutic applications in the central nervous system (CNS). Little is known about molecular factors that determine CNS foreign…”
Get full text

Trehalose‐Guanosine Glycopolymer Hydrogels Direct Adaptive Glia Responses in CNS Injury by DuBois, Eric M., Adewumi, Honour O., O'Connor, Payton R., Labovitz, Jacob E., O'Shea, Timothy M.

“…Neural tissue damaged after central nervous system (CNS) injury does not naturally regenerate but is instead replaced by non‐neural fibrotic scar tissue that…”
Get full text

Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury by Slotkin, Jonathan R, Pritchard, Christopher D, Luque, Brian, Ye, Janice, Layer, Richard T, Lawrence, Mathew S, O'Shea, Timothy M, Roy, Roland R, Zhong, Hui, Vollenweider, Isabel, Edgerton, V. Reggie, Courtine, Grégoire, Woodard, Eric J, Langer, Robert

“…Abstract Tissue loss significantly reduces the potential for functional recovery after spinal cord injury. We previously showed that implantation of porous…”
Get full text

Author Correction: Divergent transcriptional regulation of astrocyte reactivity across disorders by Burda, Joshua E., O’Shea, Timothy M., Ao, Yan, Suresh, Keshav B., Wang, Shinong, Bernstein, Alexander M., Chandra, Ashu, Deverasetty, Sandeep, Kawaguchi, Riki, Kim, Jae H., McCallum, Sarah, Rogers, Alexandra, Wahane, Shalaka, Sofroniew, Michael V.

Get full text

Bilayered scaffolds for osteochondral tissue engineering by O'Shea, Timothy M, Miao, Xigeng

“…Osteoarthritis (OA) is a prevalent degenerative joint disease that places a significant burden on the socioeconomic efficacy of communities around the world…”
Get more information

A new model for in vitro testing of vitreous substitute candidates by Barth, Henrik, Crafoord, Sven, O’Shea, Timothy M., Pritchard, Christopher D., Langer, Robert, Ghosh, Fredrik

“…Purpose To describe a new model for in vitro assessment of novel vitreous substitute candidates. Methods The biological impact of three vitreous substitute…”
Get full text

Astrocyte scar formation aids CNS axon regeneration by Anderson, Mark A., Burda, Joshua E., Ren, Yilong, Ao, Yan, O’Shea, Timothy M., Kawaguchi, Riki, Coppola, Giovanni, Khakh, Baljit S., Deming, Timothy J., Sofroniew, Michael V.

“…Transected axons fail to regrow in the mature central nervous system (CNS). Astrocyte scars are widely regarded as causal in this failure. Here, using three…”
Get full text