Search Results - "O’Shea, JJ"

Activation of STAT4 by IL-12 and IFN-alpha: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation by Cho, SS, Bacon, CM, Sudarshan, C, Rees, RC, Finbloom, D, Pine, R, O'Shea, JJ

“…The immunoregulatory cytokine IL-12 plays a central role in cell-mediated immune responses through its effects on NK cells and T lymphocytes. While IL-12 is…”
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A peek at PIAS by O'Shea, John J, Watford, Wendy

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Retroviral-Mediated Gene Correction for X-Linked Severe Combined Immunodeficiency by Candotti, Fabio, Johnston, James A., Puck, Jennifer M., Sugamura, Kazuo, O'Shea, John J., Blaese, R.Michael

“…X-linked severe combined immunodeficiency (XSCID) is a lethal disease caused by a defect in the gene encoding the common γ chain (γc) of the receptor for…”
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Thrombopoietin Induces Tyrosine Phosphorylation and Activation of the Janus Kinase, JAK2 by Tortolani, P.Justin, Johnston, James A., Bacon, Chris M., McVicar, Daniel W., Shimosaka, Akihiro, Linnekin, Diana, Longo, Dan L., O'Shea, John J.

“…Thrombopoietin (TPO) is a recently characterized growth and differentiation factor for megakaryocytes and platelets that exerts its effects via the receptor,…”
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Cytokine Signaling in 2002: New Surprises in the Jak/Stat Pathway by O'Shea, John J, Gadina, Massimo, Schreiber, Robert D

“…The importance of Jak-Stat pathway signaling in regulating cytokine-dependent gene expression and cellular development/survival is well established…”
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Rapid Enhancer Remodeling and Transcription Factor Repurposing Enable High Magnitude Gene Induction upon Acute Activation of NK Cells by Sciumè, Giuseppe, Mikami, Yohei, Jankovic, Dragana, Nagashima, Hiroyuki, Villarino, Alejandro V., Morrison, Tasha, Yao, Chen, Signorella, Sadie, Sun, Hong-Wei, Brooks, Stephen R., Fang, Difeng, Sartorelli, Vittorio, Nakayamada, Shingo, Hirahara, Kiyoshi, Zitti, Beatrice, Davis, Fred P., Kanno, Yuka, O’Shea, John J., Shih, Han-Yu

“…Innate immune responses rely on rapid and precise gene regulation mediated by accessibility of regulatory regions to transcription factors (TFs). In natural…”
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NCR+ ILC3 maintain larger STAT4 reservoir via T‐BET to regulate type 1 features upon IL‐23 stimulation in mice by Mikami, Yohei, Scarno, Gianluca, Zitti, Beatrice, Shih, Han‐Yu, Kanno, Yuka, Santoni, Angela, O'Shea, John J, Sciumè, Giuseppe

“…Innate lymphoid cells (ILCs) producing IL‐22 and/or IL‐17, designated as ILC3, comprise a heterogeneous subset of cells involved in regulation of gut barrier…”
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Characterization of the family of dimers associated with Fc receptors (Fc epsilon RI and Fc gamma RIII) by Letourneur, O, Kennedy, IC, Brini, AT, Ortaldo, JR, O'Shea, JJ, Kinet, JP

“…The receptor for IgE (Fc epsilon RI) is a multimeric complex containing one alpha chain, one beta chain with four transmembrane domains and one homodimer of…”
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Cytokines and autoimmunity by Ma, Averil, O'Shea, John J, Lipsky, Peter

“…Cytokines have crucial functions in the development, differentiation and regulation of immune cells. As a result, dysregulation of cytokine production or…”
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Signaling by IL-12 and IL-23 and the immunoregulatory roles of STAT4 by Watford, Wendy T., Hissong, Bruce D., Bream, Jay H., Kanno, Yuka, Muul, Linda, O'Shea, John J.

“…Produced in response to a variety of pathogenic organisms, interleukin (IL)‐12 and IL‐23 are key immunoregulatory cytokines that coordinate innate and adaptive…”
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IFN Regulatory Factor-4 and -8 Govern Dendritic Cell Subset Development and Their Functional Diversity by Tamura, Tomohiko, Tailor, Prafullakumar, Yamaoka, Kunihiro, Kong, Hee Jeong, Tsujimura, Hideki, O'Shea, John J, Singh, Harinder, Ozato, Keiko

“…Dendritic cells (DCs) are bone marrow (BM)-derived APCs central to both innate and adaptive immunity. DCs are a heterogeneous cell population composed of…”
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T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription by Usui, Takashi, Preiss, Jan C, Kanno, Yuka, Yao, Zheng Ju, Bream, Jay H, O'Shea, John J, Strober, Warren

“…T helper type 1 (Th1) development is facilitated by interrelated changes in key intracellular factors, particularly signal transducer and activator of…”
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Induction of T cell differentiation and lymphomagenesis in the thymus of mice with severe combined immune deficiency (SCID) by Murphy, WJ, Durum, SK, Anver, MR, Ferris, DK, McVicar, DW, O'Shea, JJ, Ruscetti, SK, Smith, MR, Young, HA, Longo, DL

“…Severe combined immune deficiency (SCID) mice have a defect in their recombinase system and cannot productively rearrange their immune receptor genes. Thus,…”
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Immunology What does it mean to be just 17? by Tato, Cristina M, O'Shea, John J

“…For a long time it was thought that there are only two types of T helper cell. But it is becoming clear that there may be other lineages that influence…”
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The biology of IL-12: coordinating innate and adaptive immune responses by Watford, Wendy T, Moriguchi, Masato, Morinobu, Akio, O’Shea, John J

“…Cytokines play critical roles in regulating all aspects of immune responses, including lymphoid development, homeostasis, differentiation, tolerance and…”
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Stat5a/b Are Essential for Normal Lymphoid Development and Differentiation by Yao, Zhengju, Cui, Yongzhi, Watford, Wendy T., Bream, Jay H., Yamaoka, Kunihiro, Hissong, Bruce D., Li, Denise, Durum, Scott K., Jiang, Qiong, Bhandoola, Avinash, Hennighausen, Lothar, O'Shea, John J.

“…Cytokines that use the common gamma chain γc are critical for lymphoid development and function. Mutations of the IL-7 receptor, γc, or its associated kinase,…”
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A new modality for immunosuppression: targeting the JAK/STAT pathway by O'Shea, John J, Borie, Dominic C, Changelian, Paul S, Pesu, Marko

“…Thousands of organs are transplanted each year and millions of people suffer from autoimmune diseases, which creates a need for an armamentarium of…”
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Molecular Phylogeny within Type I Cytokines and Their Cognate Receptors by Boulay, Jean-Louis, O'Shea, John J., Paul, William E.

“…Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I…”
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Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells by Galon, Jérôme, Franchimont, Denis, Hiroi, Naoki, Frey, Gregory, Boettner, Antje, Ehrhart-Bornstein, Monika, O’shea, John J., Chrousos, George P., Bornstein, Stefan R.

“…Glucocorticoids continue to be the ma‐jor immunomodulatory agents used in clinical medicine today. However, their actions as anti‐inflammatory and…”
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JAKS AND STATS: Biological Implications by Leonard, Warren J, O'Shea, John J

“…Cytokines and interferons are molecules that play central roles in the regulation of a wide array of cellular functions in the lympho-hematopoietic system…”
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