Search Results - "O’Shea, Erin K."

Signal-dependent dynamics of transcription factor translocation controls gene expression by Hao, Nan, O'Shea, Erin K

“…The Msn2 transcription factor is translocated to the nucleus to activate transcription of hundreds of genes in response to various environmental stimuli…”
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Promoter decoding of transcription factor dynamics involves a trade‐off between noise and control of gene expression by Hansen, Anders S, O'Shea, Erin K

“…Numerous transcription factors (TFs) encode information about upstream signals in the dynamics of their activation, but how downstream genes decode these…”
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Noise in Gene Expression: Origins, Consequences, and Control by Raser, Jonathan M, O'Shea, Erin K

“…Genetically identical cells and organisms exhibit remarkable diversity even when they have identical histories of environmental exposure. Noise, or variation,…”
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Oscillations in supercoiling drive circadian gene expression in cyanobacteria by Vijayan, Vikram, Zuzow, Rick, O'Shea, Erin K

“…The cyanobacterium Synechococcus elongatus PCC 7942 exhibits oscillations in mRNA transcript abundance with 24-h periodicity under continuous light conditions…”
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Control of Stochasticity in Eukaryotic Gene Expression by Raser, Jonathan M., O'Shea, Erin K.

“…Noise, or random fluctuations, in gene expression may produce variability in cellular behavior. To measure the noise intrinsic to eukaryotic gene expression,…”
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Increasing gender diversity in the STEM research workforce by Greider, Carol W, Sheltzer, Jason M, Cantalupo, Nancy C, Copeland, Wilbert B, Dasgupta, Nilanjana, Hopkins, Nancy, Jansen, Jaclyn M, Joshua-Tor, Leemor, McDowell, Gary S, Metcalf, Jessica L, McLaughlin, BethAnn, Olivarius, Ann, O'Shea, Erin K, Raymond, Jennifer L, Ruebain, David, Steitz, Joan A, Stillman, Bruce, Tilghman, Shirley M, Valian, Virginia, Villa-Komaroff, Lydia, Wong, Joyce Y

“…Policies must address harassment and bias Women experience substantial, gender-specific barriers that can impede their advancement in research careers. These…”
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A quantitative model of transcription factor-activated gene expression by O'Shea, Erin K, Kim, Harold D

“…The effect of transcription factor affinity and accessibility on gene expression has been difficult to quantify and model. The contribution of both…”
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A high resolution map of a cyanobacterial transcriptome by Vijayan, Vikram, Jain, Isha H, O'Shea, Erin K

“…Previous molecular and mechanistic studies have identified several principles of prokaryotic transcription, but less is known about the global transcriptional…”
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Mechanisms of organelle biogenesis govern stochastic fluctuations in organelle abundance by Mukherji, Shankar, O'Shea, Erin K

“…Fluctuations in organelle abundance can profoundly limit the precision of cell biological processes from secretion to metabolism. We modeled the dynamics of…”
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Plasticity-induced actin polymerization in the dendritic shaft regulates intracellular AMPA receptor trafficking by Wong, Victor C, Houlihan, Patrick R, Liu, Hui, Walpita, Deepika, DeSantis, Michael C, Liu, Zhe, O'Shea, Erin K

“…AMPA-type receptors (AMPARs) are rapidly inserted into synapses undergoing plasticity to increase synaptic transmission, but it is not fully understood if and…”
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Global analysis of protein localization in budding yeast by O'Shea, Erin K, Huh, Won-Ki, Falvo, James V, Gerke, Luke C, Carroll, Adam S, Howson, Russell W, Weissman, Jonathan S

“…A fundamental goal of cell biology is to define the functions of proteins in the context of compartments that organize them in the cellular environment. Here…”
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Global analysis of protein expression in yeast by Weissman, Jonathan S, Ghaemmaghami, Sina, Huh, Won-Ki, Bower, Kiowa, Howson, Russell W, Belle, Archana, Dephoure, Noah, O'Shea, Erin K

“…The availability of complete genomic sequences and technologies that allow comprehensive analysis of global expression profiles of messenger RNA have greatly…”
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Identification of a transporter complex responsible for the cytosolic entry of nitrogen-containing bisphosphonates by Yu, Zhou, Surface, Lauren E, Park, Chong Yon, Horlbeck, Max A, Wyant, Gregory A, Abu-Remaileh, Monther, Peterson, Timothy R, Sabatini, David M, Weissman, Jonathan S, O'Shea, Erin K

“…Nitrogen-containing-bisphosphonates (N-BPs) are a class of drugs widely prescribed to treat osteoporosis and other bone-related diseases. Although previous…”
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Looking back and looking forward at Janelia by Rubin, Gerald M, O'Shea, Erin K

“…Starting a new research campus is a leap of faith. Only later, in the full measure of time, is it possible to take stock of what has worked and what could have…”
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Sfp1 Is a Stress- and Nutrient-Sensitive Regulator of Ribosomal Protein Gene Expression by Marion, Rosa M., Regev, Aviv, Segal, Eran, Barash, Yoseph, Koller, Daphne, Friedman, Nir, O'Shea, Erin K.

“…Yeast cells modulate their protein synthesis capacity in response to physiological needs through the transcriptional control of ribosomal protein (RP) genes…”
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Sequence Determinants of Circadian Gene Expression Phase in Cyanobacteria by Vijayan, Vikram, O'Shea, Erin K

“…The cyanobacterium Synechococcus elongatus PCC 7942 exhibits global biphasic circadian oscillations in gene expression under constant-light conditions. Class I…”
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Regulation of Chromatin Remodeling by Inositol Polyphosphates by Steger, David J., Haswell, Elizabeth S., Miller, Aimee L., Wente, Susan R., O'Shea, Erin K.

“…Chromatin remodeling is required for efficient transcription of eukaryotic genes. In a genetic selection for budding yeast mutants that were defective in…”
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Yeast go the whole HOG for the hyperosmotic response by O'Rourke, Sean M, Herskowitz, Ira, O'Shea, Erin K

“…An evolutionarily conserved mitogen-activated protein kinase pathway – the high osmolarity glycerol (HOG) pathway – mediates the hyperosmotic response in…”
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Phosphate Transport and Sensing in Saccharomyces cerevisiae by Wykoff, Dennis D, O'Shea, Erin K

“…Cellular metabolism depends on the appropriate concentration of intracellular inorganic phosphate; however, little is known about how phosphate concentrations…”
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A systematic high-throughput screen of a yeast deletion collection for mutants defective in PHO5 regulation by Huang, Sidong, O'Shea, Erin K

“…In response to phosphate limitation, Saccharomyces cerevisiae induces transcription of a set of genes important for survival. One of these genes is PHO5, which…”
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