Search Results - "O’Shaughnessy, M"

Genetic Markers Regulating Blood Pressure in Extreme Discordant Sib Pairs by Yasmin, O'Shaughnessy, Kevin M

“…Genome-wide scans performed in affected sib pairs have revealed small and often inconsistent clues to the loci responsible for the inherited components of…”
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WNK signalling pathways in blood pressure regulation by Murthy, Meena, Kurz, Thimo, O’Shaughnessy, Kevin M.

“…Hypertension (high blood pressure) is a major public health problem affecting more than a billion people worldwide with complications, including stroke, heart…”
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Glomerular disease frequencies by race, sex and region: results from the International Kidney Biopsy Survey by O'Shaughnessy, Michelle M, Hogan, Susan L, Thompson, Bawana D, Coppo, Rosanna, Fogo, Agnes B, Jennette, J Charles

“…Large-scale studies comparing glomerular disease frequencies across continents are lacking. We surveyed 29 nephropathology laboratories in four continents…”
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Gordon Syndrome: a continuing story by O’Shaughnessy, Kevin M.

“…Gordon Syndrome (GS) is a rare familial hypertension syndrome with a characteristic hyperkalaemia which distinguishes it from other syndromic forms of…”
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Role for Germline Mutations and a Rare Coding Single Nucleotide Polymorphism Within the KCNJ5 Potassium Channel in a Large Cohort of Sporadic Cases of Primary Aldosteronism by Murthy, Meena, Xu, Shengxin, Massimo, Gianmichele, Wolley, Martin, Gordon, Richard D, Stowasser, Michael, O’Shaughnessy, Kevin M

“…Primary aldosteronism (autonomous aldosterone production with suppressed renin) plays an important pathophysiological role in what has been previously labeled…”
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Somatic Mutations Affecting the Selectivity Filter of KCNJ5 Are Frequent in 2 Large Unselected Collections of Adrenal Aldosteronomas by Azizan, Elena A.B, Murthy, Meena, Stowasser, Michael, Gordon, Richard, Kowalski, Bartosz, Xu, Shengxin, Brown, Morris J, OʼShaughnessy, Kevin M

“…Primary hyperaldosteronism, one cause of which is aldosterone-producing adenomas (APAs), may account for ≤5% to 10% of cases of essential hypertension…”
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An experimental-numerical study of heat transfer enhancement in a minichannel using asymmetric pulsating flows by Kumavat, Parth S., Alimohammadi, Sajad, O'Shaughnessy, Seamus M.

“…The development of current and next generation high performance electronic devices has led to miniaturization in more densely packed spaces. The increasing…”
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Differential Killing of Salmonella enterica Serovar Typhi by Antibodies Targeting Vi and Lipopolysaccharide O:9 Antigen by Hart, Peter J, O'Shaughnessy, Colette M, Siggins, Matthew K, Bobat, Saeeda, Kingsley, Robert A, Goulding, David A, Crump, John A, Reyburn, Hugh, Micoli, Francesca, Dougan, Gordon, Cunningham, Adam F, MacLennan, Calman A

“…Salmonella enterica serovar Typhi expresses a capsule of Vi polysaccharide, while most Salmonella serovars, including S. Enteritidis and S. Typhimurium, do…”
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Cause of kidney disease and cardiovascular events in a national cohort of US patients with end-stage renal disease on dialysis: a retrospective analysis by O’Shaughnessy, Michelle M, Liu, Sai, Montez-Rath, Maria E, Lafayette, Richard A, Winkelmayer, Wolfgang C

“…Abstract Aims End-stage renal disease (ESRD) is a strong cardiovascular risk factor. We aimed to determine the extent to which cause of kidney disease…”
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Combinations of maternal KIR and fetal HLA-C genes influence the risk of preeclampsia and reproductive success by Hiby, Susan E, Walker, James J, O'shaughnessy, Kevin M, Redman, Christopher W G, Carrington, Mary, Trowsdale, John, Moffett, Ashley

“…Preeclampsia is a serious complication of pregnancy in which the fetus receives an inadequate supply of blood due to failure of trophoblast invasion. There is…”
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β1-Adrenoreceptor Polymorphisms and Blood Pressure: 49S Variant Increases Plasma Renin But Not Blood Pressure in Hypertensive Patients by Sandilands, Alastair J, O’Shaughnessy, Kevin M, Yasmin

“…Abstract BACKGROUND Activation of beta-1 adrenoreceptor (β1-AR) in the kidney releases renin that plays a major role in the maintenance of blood pressure…”
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Characterisation of the Cullin‐3 mutation that causes a severe form of familial hypertension and hyperkalaemia by Schumacher, Frances‐Rose, Siew, Keith, Zhang, Jinwei, Johnson, Clare, Wood, Nicola, Cleary, Sarah E, Al Maskari, Raya S, Ferryman, James T, Hardege, Iris, Yasmin, Figg, Nichola L, Enchev, Radoslav, Knebel, Axel, O'Shaughnessy, Kevin M, Kurz, Thimo

“…Deletion of exon 9 from Cullin‐3 (CUL3, residues 403–459: CUL3 Δ403–459 ) causes pseudohypoaldosteronism type IIE (PHA2E), a severe form of familial…”
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Gender Differences in Authorship and Quality of Anesthesia Clinical Practice Guidelines From 2016 to 2020 Using the Appraisal of Guidelines for Research and Evaluation II Instrument by Rong, Lisa Q, Martinez, Andrew P, Rahouma, Mohamed, Lopes, Alexandra J, Lee, Jerry Y, Wright, Drew N, Demetres, Michelle, Kachulis, Bessie, O'Shaughnessy, Sinead M

“…Women continue to be underrepresented in academic anesthesiology. This study assessed guidelines in anesthesia journals over the past 5 years, evaluating…”
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Going for mainstream deammonification from bench to full scale for maximized resource efficiency by WETT, B, OMARI, A, NYHUIS, G, O'SHAUGHNESSY, M, PODMIRSEG, S. M, HAN, M, AKINTAYO, O, BRANDON, M. Gómez, MURTHY, S, BOTT, C, HELL, M, TAKACS, I

“…A three-pronged coordinated research effort was undertaken by cooperating utilities at three different experimental scales investigating bioaugmentation,…”
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Agreement between renal prescribing references and determination of prescribing appropriateness in hospitalized patients with chronic kidney disease by O'Shaughnessy, M, Allen, N, O'Regan, J, Payne-Danson, E, Mentre, L, Davin, D, Lavin, P, Grimes, T

“…Chronic kidney disease (CKD) is a risk factor for adverse drug events. The clinical significance of discordance between renal prescribing references is…”
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Modified HEK cells simulate DCT cells in their sensitivity and response to changes in extracellular K by Murthy, Meena, O’Shaughnessy, Kevin M.

“…A potassium (K+) rich diet is known to have an antihypertensive effect that has been embodied by the NHLBI in the DASH diet. However, the molecular basis for…”
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Management of paediatric humeral shaft fractures and associated nerve palsy by O'Shaughnessy, M. A., Parry, J. A., Liu, H., Stans, A. A., Larson, A. N., Milbrandt, T. A.

“…Abstract Purpose The aim of this study is to review the management of all paediatric humerus diaphyseal fractures treated at a single institution over a…”
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Treating hypertension in patients with medical comorbidities by Kennard, Lucinda, O’Shaughnessy, Kevin M

“…Summary of first line treatment in patients with hypertension and comorbidities Chronic kidney disease Diabetes status and urinary albumin:creatinine ratio…”
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Critical role of the SPAK protein kinase CCT domain in controlling blood pressure by Zhang, Jinwei, Siew, Keith, Macartney, Thomas, O'Shaughnessy, Kevin M, Alessi, Dario R

“…The STE20/SPS1-related proline/alanine-rich kinase (SPAK) controls blood pressure (BP) by phosphorylating and stimulating the Na-Cl (NCC) and Na-K-2Cl (NKCC2)…”
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Role of the WNK‐activated SPAK kinase in regulating blood pressure by Rafiqi, Fatema H., Zuber, Annie Mercier, Glover, Mark, Richardson, Ciaran, Fleming, Stewart, Jovanović, Sofija, Jovanović, Aleksandar, O'Shaughnessy, Kevin M., Alessi, Dario R.

“…Mutations within the with‐no‐K(Lys) (WNK) kinases cause Gordon's syndrome characterized by hypertension and hyperkalaemia. WNK kinases phosphorylate and…”
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