Search Results - "O’Rourke, Joseph R"
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Fatty acid-binding proteins 5 and 7 gene deletion increases sucrose consumption and diminishes forced swim immobility time
Published in Behavioural pharmacology (01-09-2018)“…Inhibition and genetic deletion of fatty acid-binding proteins (FABPs) 5 and 7 have been shown to increase the levels of the endocannabinoid anandamide as well…”
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Chronic Ethanol Consumption Profoundly Alters Regional Brain Ceramide and Sphingomyelin Content in Rodents
Published in ACS chemical neuroscience (18-02-2015)“…Ceramides (CER) are involved in alcohol-induced neuroinflammation. In a mouse model of chronic alcohol exposure, 16 CER and 18 sphingomyelin (SM)…”
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Examination of the Addictive and Behavioral Properties of Fatty Acid-Binding Protein Inhibitor SBFI26
Published in Frontiers in psychiatry (05-04-2016)“…The therapeutic properties of cannabinoids have been well demonstrated but are overshadowed by such adverse effects as cognitive and motor dysfunction, as well…”
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Mouse Social Interaction Test (MoST): a quantitative computer automated analysis of behavior
Published in Journal of Neural Transmission (2017)“…Rodents are the most commonly used preclinical model of human disease assessing the mechanism(s) involved as well as the role of genetics, epigenetics, and…”
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Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior
Published in Oncotarget (12-04-2016)“…Aging produces cellular, molecular, and behavioral changes affecting many areas of the brain. The dopamine (DA) system is known to be vulnerable to the effects…”
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