Search Results - "O’Regan, David"

Situational awareness - The surgeon and the advanced motorist by O'Regan, David J., Rudd, John

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Elevated expression levels of miR-143/5 in saphenous vein smooth muscle cells from patients with Type 2 diabetes drive persistent changes in phenotype and function by Riches, Kirsten, Alshanwani, Aliah R, Warburton, Philip, O’Regan, David J, Ball, Stephen G, Wood, Ian C, Turner, Neil A, Porter, Karen E

“…Abstract Type 2 diabetes (T2DM) promotes premature atherosclerosis and inferior prognosis after arterial reconstruction. Vascular smooth muscle cells (SMC)…”
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THE GLOBAL INTERNAL AUDIT STANDARDS - OLD WINE IN NEW BOTTLES? by Lenz, Rainer, O'Regan, David J.

“…In this paper the authors suggest that the Global Internal Audit Standards (the IIA's Standards) issued in January 2024 resemble the placing of old wine in new…”
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Investigating inherent functional differences between human cardiac fibroblasts cultured from nondiabetic and Type 2 diabetic donors by Sedgwick, Bryony, Riches, Kirsten, Bageghni, Sumia A, O’Regan, David J, Porter, Karen E, Turner, Neil A

“…Abstract Introduction Type 2 diabetes mellitus (T2DM) promotes adverse myocardial remodeling and increased risk of heart failure; effects that can occur…”
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Human cardiac fibroblasts express ICAM-1, E-selectin and CXC chemokines in response to proinflammatory cytokine stimulation by Turner, Neil A., Das, Anupam, O’Regan, David J., Ball, Stephen G., Porter, Karen E.

“…Neutrophil attraction and adhesion to endothelial cells occurs via well defined mechanisms, yet the ability of other cell types to express neutrophil-binding…”
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p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts by Sinfield, John K., Das, Anupam, O’Regan, David J., Ball, Stephen G., Porter, Karen E., Turner, Neil A.

“…► The p38 MAPK signaling pathway regulates cardiac remodeling. ► Human cardiac fibroblasts express the α, γ and δ subtypes of p38 MAPK. ► IL-1 selectively…”
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Role of MicroRNA-145 in DNA Damage Signalling and Senescence in Vascular Smooth Muscle Cells of Type 2 Diabetic Patients by Hemmings, Karen E, Riches-Suman, Kirsten, Bailey, Marc A, O'Regan, David J, Turner, Neil A, Porter, Karen E

“…Increased cardiovascular morbidity and mortality in individuals with type 2 diabetes (T2DM) is a significant clinical problem. Despite advancements in…”
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Chronic Insomnia Disorder across Europe: Expert Opinion on Challenges and Opportunities to Improve Care by Ellis, Jason, Ferini-Strambi, Luigi, García-Borreguero, Diego, Heidbreder, Anna, O'Regan, David, Parrino, Liborio, Selsick, Hugh, Penzel, Thomas

“…One in ten adults in Europe have chronic insomnia, which is characterised by frequent and persistent difficulties initiating and/or maintaining sleep and daily…”
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The neurophysiologic landscape of the sleep onset: a systematic review by Biabani, Nazanin, Birdseye, Adam, Higgins, Sean, Delogu, Alessio, Rosenzweig, Jan, Cvetkovic, Zoran, Nesbitt, Alexander, Drakatos, Panagis, Steier, Joerg, Kumari, Veena, O’Regan, David, Rosenzweig, Ivana

“…BackgroundThe sleep onset process is an ill-defined complex process of transition from wakefulness to sleep, characterized by progressive modifications at the…”
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Pregnenolone sulphate-independent inhibition of TRPM3 channels by progesterone by Majeed, Yasser, Tumova, Sarka, Green, Ben L, Seymour, Victoria A.L, Woods, Daniel M, Agarwal, Anil K, Naylor, Jacqueline, Jiang, Shannon, Picton, Helen M, Porter, Karen E, O’Regan, David J, Muraki, Katsuhiko, Fishwick, Colin W.G, Beech, David J

“…Abstract Transient Receptor Potential Melastatin 3 (TRPM3) is a widely expressed calcium-permeable non-selective cation channel that is stimulated by high…”
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MicroRNA‐21 drives the switch to a synthetic phenotype in human saphenous vein smooth muscle cells by Alshanwani, Aliah R., Riches‐Suman, Kirsten, O'Regan, David J., Wood, Ian C., Turner, Neil A., Porter, Karen E.

“…Cardiovascular disease is a leading cause of morbidity and mortality. Smooth muscle cells (SMC) comprising the vascular wall can switch phenotypes from…”
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Type 2 diabetes impairs venous, but not arterial smooth muscle cell function: Possible role of differential RhoA activity by Riches, Kirsten, Warburton, Philip, O’Regan, David J, Turner, Neil A, Porter, Karen E

“…Abstract Background/purpose Coronary heart disease is the leading cause of morbidity in patients with type 2 diabetes mellitus (T2DM), frequently resulting in…”
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Orai3 Surface Accumulation and Calcium Entry Evoked by Vascular Endothelial Growth Factor by Li, Jing, Bruns, Alexander-Francisco, Hou, Bing, Rode, Baptiste, Webster, Peter J, Bailey, Marc A, Appleby, Hollie L, Moss, Nicholas K, Ritchie, Judith E, Yuldasheva, Nadira Y, Tumova, Sarka, Quinney, Matthew, McKeown, Lynn, Taylor, Hilary, Prasad, K Raj, Burke, Dermot, O’Regan, David, Porter, Karen E, Foster, Richard, Kearney, Mark T, Beech, David J

“…OBJECTIVE—Vascular endothelial growth factor (VEGF) acts, in part, by triggering calcium ion (Ca) entry. Here, we sought understanding of a Synta66-resistant…”
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Monolayer Capping Provides Close to Optimal Resistance to Laser Dewetting of Au Films by Murray, Christopher P., Mamyraimov, Daniyar, Ali, Mugahid, Downing, Clive, Povey, Ian M., McCloskey, David, O’Regan, David D., Donegan, John F.

“…Next-generation heat-assisted magnetic recording (HAMR) relies on fast, localized heating of the magnetic medium during the write process. Au plasmonic…”
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Sleep: the neglected life factor in adults with intellectual disabilities by Korb, Laura, O'Regan, David, Conley, Jane, Dillon, Emma, Briggs, Rachel, Courtenay, Ken, Perera, Bhathika

“…Sleep is vital for our physical and mental health. Studies have shown that there is a high prevalence of sleep disorders and sleep difficulties amongst adults…”
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Group Cognitive Behavioural Therapy for Non-Rapid Eye Movement Parasomnias: Long-Term Outcomes and Impact of COVID-19 Lockdown by Laroche, Matthias, Biabani, Nazanin, Drakatos, Panagis, Selsick, Hugh, Leschziner, Guy, Steier, Joerg, Young, Allan H, Eriksson, Sofia, Nesbitt, Alexander, Kumari, Veena, Rosenzweig, Ivana, O'Regan, David

“…Prior to the COVID-19 pandemic, we demonstrated the efficacy of a novel Cognitive Behavioural Therapy programme for the treatment of Non-Rapid Eye Movement…”
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Mechanism of TNFα-induced IL-1α, IL-1β and IL-6 expression in human cardiac fibroblasts : Effects of statins and thiazolidinediones by TURNER, Neil A, MUGHAL, Romana S, WARBURTON, Philip, O'REGAN, David J, BALL, Stephen G, PORTER, Karen E

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Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma‐1 receptor ligands by Amer, Mohamed S, McKeown, Lynn, Tumova, Sarka, Liu, Ruifeng, Seymour, Victoria AL, Wilson, Lesley A, Naylor, Jacqueline, Greenhalgh, Katriona, Hou, Bing, Majeed, Yasser, Turner, Paul, Sedo, Alicia, O'Regan, David J, Li, Jing, Bon, Robin S, Porter, Karen E, Beech, David J

“…Background and Purpose The Sigma‐1 receptor (Sig1R) impacts on calcium ion signalling and has a plethora of ligands. This study investigated Sig1R and its…”
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Self-management needs of children with JIA in Ireland: a qualitative survey of families by Condon, Cillin, O'Regan, David, MacDermott, Emma, Killeen, Orla

“…Aim: To explore the self-management needs and coping activities of children with JIA and their parents. Families and children with JIA experience many…”
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Cardiac surgical theatre traffic: time for traffic calming measures? by Young, Richard S, O'Regan, David J

“…Surgical site infections (SSIs) remain a significant cause of postoperative complications. The risk of death from a medical error in a UK hospital remains one…”
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