Search Results - "O’Neill, Luke AJ"

Metabolic reprogramming in macrophages and dendritic cells in innate immunity by Kelly, Beth, O'Neill, Luke AJ

“…Activation of macrophages and dendritic cells （DCs） by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from…”
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Macrophage innate training induced by IL-4 and IL-13 activation enhances OXPHOS driven anti-mycobacterial responses by Lundahl, Mimmi L E, Mitermite, Morgane, Ryan, Dylan Gerard, Case, Sarah, Williams, Niamh C, Yang, Ming, Lynch, Roisin I, Lagan, Eimear, Lebre, Filipa M, Gorman, Aoife L, Stojkovic, Bojan, Bracken, Adrian P, Frezza, Christian, Sheedy, Frederick J, Scanlan, Eoin M, O'Neill, Luke A J, Gordon, Stephen V, Lavelle, Ed C

“…Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the 'classically activated' M1 macrophage enhances…”
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A Broken Krebs Cycle in Macrophages by O’Neill, Luke A.J.

“…Macrophages undergo metabolic rewiring during polarization but details of this process are unclear. In this issue of Immunity, Jha et al. (2015) report a…”
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How Toll-like receptors signal: what we know and what we don’t know by O’Neill, Luke AJ

“…Signal transduction pathways activated by Toll-like receptors (TLRs) have continued to be a major focus of research for investigators interested in the…”
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Two for the price of one: itaconate and its derivatives as an anti-infective and anti-inflammatory immunometabolite by McGettrick, Anne F, O’Neill, Luke AJ

“…The metabolite itaconate (ITA) and its derivatives, both chemically synthesized and endogenous, have emerged as immunoregulators, with roles in limiting…”
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TCA cycle signalling and the evolution of eukaryotes by Ryan, Dylan G, Frezza, Christian, O’Neill, Luke AJ

“…A major question remaining in the field of evolutionary biology is how prokaryotic organisms made the leap to complex eukaryotic life. The prevailing theory…”
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Localisation and trafficking of Toll-like receptors: an important mode of regulation by McGettrick, Anne F, O’Neill, Luke AJ

“…In recent years the importance of the localisation and trafficking of Toll-like receptors (TLRs) and their adaptors within the cell has become apparent…”
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New developments in Toll-like receptor targeted therapeutics by Connolly, Dympna J, O’Neill, Luke AJ

“…Highlights ► TLRs have been implicated in the pathogenesis of many inflammatory diseases and cancer. ► TLRs are being targeted by agonists or antagonists to…”
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A guide to immunometabolism for immunologists by O'Neill, Luke A. J., Kishton, Rigel J., Rathmell, Jeff

“…Key Points Immunometabolism describes the changes that occur in intracellular metabolic pathways in immune cells during activation. Six major pathways have…”
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The role of itaconate in host defense and inflammation by Peace, Christian G, O'Neill, Luke Aj

“…Macrophages exposed to inflammatory stimuli including LPS undergo metabolic reprogramming to facilitate macrophage effector function. This metabolic…”
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The history of Toll-like receptors — redefining innate immunity by O'Neill, Luke A. J., Golenbock, Douglas, Bowie, Andrew G.

“…The past 15 years have seen a breakthrough in the field of innate immunity. In this Timeline article, the authors discuss the early events that led to the…”
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Metabolic regulation of NLRP3 by Hughes, Mark M., O'Neill, Luke A.J.

“…Summary A shift in our understanding of macrophage biology has come about as a result of recent discoveries in the area of metabolic reprogramming of…”
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Circadian Clock Proteins and Immunity by Curtis, Anne M., Bellet, Marina M., Sassone-Corsi, Paolo, O’Neill, Luke A.J.

“…Immune parameters change with time of day and disruption of circadian rhythms has been linked to inflammatory pathologies. A circadian-clock-controlled immune…”
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interleukin-1 receptor/Toll-like receptor superfamily: 10 years of progress by O'Neill, Luke A.J

“…The interleukin-1 receptor (IL-1R)/Toll-like receptor (TLR) superfamily was first defined in 1998 as a family of proteins that contain the Toll-IL-1 receptor…”
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When Signaling Pathways Collide: Positive and Negative Regulation of Toll-like Receptor Signal Transduction by O'Neill, Luke A.J.

“…Toll-like receptor (TLR) signaling is subjected to crosstalk from other signals, with a resulting positive or negative effect. There is complex crosstalk…”
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Modulatory mechanisms controlling the NLRP3 inflammasome in inflammation: recent developments by Haneklaus, Moritz, O’Neill, Luke AJ, Coll, Rebecca C

“…Highlights ► Overview of the control of NLRP3 activity by the cellular redox environment. ► miRNA-223 and viral factors can inhibit NLRP3. ► Kinase and calcium…”
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A Long Noncoding RNA Mediates Both Activation and Repression of Immune Response Genes by Carpenter, Susan, Aiello, Daniel, Atianand, Maninjay K., Ricci, Emiliano P., Gandhi, Pallavi, Hall, Lisa L., Byron, Meg, Monks, Brian, Henry-Bezy, Meabh, Lawrence, Jeanne B., O'Neill, Luke A. J., Moore, Melissa J., Caffrey, Daniel R., Fitzgerald, Katherine A.

“…An inducible program of inflammatory gene expression is central to antimicrobial defenses. This response is controlled by a collaboration involving…”
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The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling by O'Neill, Luke A. J, Bowie, Andrew G

“…Signalling by Toll-like receptors (TLRs) involves five adaptor proteins known as MyD88, MAL, TRIF, TRAM and SARM. Recent insights have revealed additional…”
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Cutting edge: miR-223 and EBV miR-BART15 regulate the NLRP3 inflammasome and IL-1β production by Haneklaus, Moritz, Gerlic, Motti, Kurowska-Stolarska, Mariola, Rainey, Ashleigh-Ann, Pich, Dagmar, McInnes, Iain B, Hammerschmidt, Wolfgang, O'Neill, Luke A J, Masters, Seth L

“…Although microRNA (miRNA) regulation of TLR signaling is well established, this has not yet been observed for NLR proteins or the inflammasomes they form. We…”
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The Cellular and Molecular Basis of Translational Immunometabolism by Norata, Giuseppe Danilo, Caligiuri, Giuseppina, Chavakis, Triantafyllos, Matarese, Giuseppe, Netea, Mihai Gheorge, Nicoletti, Antonino, O’Neill, Luke A.J., Marelli-Berg, Federica M.

“…The immune response requires major changes to metabolic processes, and indeed, energy metabolism and functional activation are fully integrated in immune cells…”
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