Search Results - "O’Neill, Hester G."

Whole-Genome Characterization of Rotavirus G9P[6] and G9P[4] Strains That Emerged after Rotavirus Vaccine Introduction in Mozambique by Munlela, Benilde, João, Eva D, Strydom, Amy, Bauhofer, Adilson Fernando Loforte, Chissaque, Assucênio, Chilaúle, Jorfélia J, Maurício, Isabel L, Donato, Celeste M, O'Neill, Hester G, de Deus, Nilsa

“…Mozambique introduced the Rotarix vaccine into the National Immunization Program in September 2015. Following vaccine introduction, rotavirus A (RVA)…”
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Generation of Simian Rotavirus Reassortants with VP4- and VP7-Encoding Genome Segments from Human Strains Circulating in Africa Using Reverse Genetics by Falkenhagen, Alexander, Patzina-Mehling, Corinna, Gadicherla, Ashish K, Strydom, Amy, O'Neill, Hester G, Johne, Reimar

“…Human rotavirus A (RVA) causes acute gastroenteritis in infants and young children. The broad use of two vaccines, which are based on RVA strains from Europe…”
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Metagenomic Analysis of the Enteric RNA Virome of Infants from the Oukasie Clinic, North West Province, South Africa, Reveals Diverse Eukaryotic Viruses by Mogotsi, Milton T, Mwangi, Peter N, Bester, Phillip A, Mphahlele, M Jeffrey, Seheri, Mapaseka L, O'Neill, Hester G, Nyaga, Martin M

“…Establishing a diverse gut microbiota after birth is essential for preventing illnesses later in life. However, little knowledge exists about the total viral…”
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Molecular Epidemiology of Rotavirus A Strains Pre- and Post-Vaccine (Rotarix ® ) Introduction in Mozambique, 2012-2019: Emergence of Genotypes G3P[4] and G3P[8] by João, Eva D, Munlela, Benilde, Chissaque, Assucênio, Chilaúle, Jorfélia, Langa, Jerónimo, Augusto, Orvalho, Boene, Simone S, Anapakala, Elda, Sambo, Júlia, Guimarães, Esperança, Bero, Diocreciano, Cassocera, Marta, Cossa-Moiane, Idalécia, Mwenda, Jason M, Maurício, Isabel, O'Neill, Hester G, de Deus, Nilsa

“…Group A rotavirus (RVA) remains the most important etiological agent associated with severe acute diarrhea in children. monovalent vaccine was introduced into…”
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Corrigendum: Rotavirus-Mediated Prostaglandin E2 Production in MA104 Cells Promote Virus Attachment and Internalisation, Resulting in an Increased Viral Load by Sander, Willem J., Kemp, Gabré, Hugo, Arnold, Pohl, Carolina H., O'Neill, Hester G.

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Genetic Characterisation of South African and Mozambican Bovine Rotaviruses Reveals a Typical Bovine-like Artiodactyl Constellation Derived through Multiple Reassortment Events by Strydom, Amy, Donato, Celeste M., Nyaga, Martin M., Boene, Simone S., Peenze, Ina, Mogotsi, Milton T., João, Eva D., Munlela, Benilde, Potgieter, A. Christiaan, Seheri, Mapaseka L., de Deus, Nilsa, O’Neill, Hester G.

“…This study presents whole genomes of seven bovine rotavirus strains from South Africa and Mozambique. Double-stranded RNA, extracted from stool samples without…”
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Investigating the Domain Specificity of Phosphinic Inhibitors RXPA380 and RXP407 in Angiotensin-Converting Enzyme by Kröger, Wendy L, Douglas, Ross G, O’Neill, Hester G, Dive, Vincent, Sturrock, Edward D

“…Human somatic angiotensin-converting enzyme (ACE) is a membrane-bound dipeptidyl carboxypeptidase that contains two extracellular domains (N and C). Although…”
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Probing the Basis of Domain-Dependent Inhibition Using Novel Ketone Inhibitors of Angiotensin-Converting Enzyme by Watermeyer, Jean M, Kröger, Wendy L, O’Neill, Hester G, Sewell, B. Trevor, Sturrock, Edward D

“…Human angiotensin-converting enzyme (ACE) has two homologous domains, the N and C domains, with differing substrate preferences. X-ray crystal structures of…”
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Whole Genome Characterization and Evolutionary Analysis of G1P[8] Rotavirus A Strains during the Pre- and Post-Vaccine Periods in Mozambique (2012-2017) by Munlela, Benilde, João, Eva D, Donato, Celeste M, Strydom, Amy, Boene, Simone S, Chissaque, Assucênio, Bauhofer, Adilson F L, Langa, Jerónimo, Cassocera, Marta, Cossa-Moiane, Idalécia, Chilaúle, Jorfélia J, O'Neill, Hester G, de Deus, Nilsa

“…Mozambique introduced the Rotarix vaccine (GSK Biologicals, Rixensart, Belgium) into the National Immunization Program in September 2015. Although G1P[8] was…”
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Sequence-Based Prediction for Vaccine Strain Selection and Identification of Antigenic Variability in Foot-and-Mouth Disease Virus by Reeve, Richard, Blignaut, Belinda, Esterhuysen, Jan J, Opperman, Pamela, Matthews, Louise, Fry, Elizabeth E, De Beer, Tjaart A.P, Theron, Jacques, Rieder, Elizabeth, Vosloo, Wilna, O'Neill, Hester G, Haydon, Daniel T, Maree, Francois F

“…Identifying when past exposure to an infectious disease will protect against newly emerging strains is central to understanding the spread and the severity of…”
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Chimaeric virus-like particles derived from consensus genome sequences of human rotavirus strains co-circulating in Africa by Jere, Khuzwayo C, O'Neill, Hester G, Potgieter, A Christiaan, van Dijk, Alberdina A

“…Rotavirus virus-like particles (RV-VLPs) are potential alternative non-live vaccine candidates due to their high immunogenicity. They mimic the natural…”
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Whole-genome consensus sequence analysis of a South African rotavirus SA11 sample reveals a mixed infection with two close derivatives of the SA11-H96 strain by Mlera, Luwanika, O’Neill, Hester G., Jere, Khuzwayo C., van Dijk, Alberdina A.

“…Whole-genome, sequence-independent amplification and 454 ® pyrosequencing of a rotavirus SA11 cell culture sample with an unknown passage history yielded…”
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Characterization of domain-selective inhibitor binding in angiotensin-converting enzyme using a novel derivative of lisinopril by Watermeyer, Jean M, Kröger, Wendy L, O'Neill, Hester G, Sewell, B Trevor, Sturrock, Edward D

“…Human ACE (angiotensin-converting enzyme) (EC 3.4.15.1) is an important drug target because of its role in the regulation of blood pressure via the…”
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Prostaglandin E 2 As a Modulator of Viral Infections by Sander, Willem J, O'Neill, Hester G, Pohl, Carolina H

“…Viral infections are a major cause of infectious diseases worldwide. Inflammation and the immune system are the major host defenses against these viral…”
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Phylogenetic Analyses of Rotavirus A, B and C Detected on a Porcine Farm in South Africa by Strydom, Amy, Segone, Neo, Coertze, Roelof, Barron, Nikita, Strydom, Muller, O'Neill, Hester G

“…Rotaviruses (RVs) are known to infect various avian and mammalian hosts, including swine. The most common RVs associated with infection in pigs are A, B, C and…”
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Reactive oxygen species as potential antiviral targets by Sander, Willem J., Fourie, Corinne, Sabiu, Saheed, O'Neill, Frans H., Pohl, Carolina H., O'Neill, Hester G.

“…Reactive oxygen species (ROS) are by‐products of cellular metabolism and can be either beneficial, at low levels, or deleterious, at high levels, to the cell…”
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Prostaglandin E2 As a Modulator of Viral Infections by Sander, Willem J, O'Neill, Hester G, Pohl, Carolina H

“…Viral infections are a major cause of infectious diseases worldwide. Inflammation and the immune system are the major host defenses against these viral…”
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Evaluation of the European foundation initiative into African research in neglected tropical diseases by the African fellows by O'Neill, Hester G, Mzilahowa, Themba, de Deus, Nilsa, Njenga, Sammy M, Mmbaga, Elia J, Kariuki, Thomas M

“…  [...]using SurveyMonkey (www.surveymonkey.com), an online survey and questionnaire tool, a survey was conducted among the recipients of the first two rounds…”
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Genetic characterisation of novel G29P[14] and G10P[11] rotavirus strains from African buffalo by Strydom, Amy, Donato, Celeste, Peenze, Ina, Potgieter, A. Christiaan, Seheri, Mapaseka, O'Neill, Hester G.

“…We report the first description of rotavirus A strains in African buffalo (Syncerus caffer). Following RNA extraction from stool samples, cDNA was prepared,…”
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Rotavirus-Mediated Prostaglandin E 2 Production in MA104 Cells Promotes Virus Attachment and Internalisation, Resulting in an Increased Viral Load by Sander, Willem J, Kemp, Gabré, Hugo, Arnold, Pohl, Carolina H, O'Neill, Hester G

“…Rotaviruses are one of the leading causes of severe dehydrating diarrhoea in infants and children under the age of five. Despite the introduction of vaccines,…”
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