Search Results - "O’Neal, J."

One Is Not Enough: Understanding and Modeling Polysubstance Use by Crummy, Elizabeth A., O’Neal, Timothy J., Baskin, Britahny M., Ferguson, Susan M.

“…Substance use disorder (SUD) is a chronic, relapsing disease with a highly multifaceted pathology that includes (but is not limited to) sensitivity to…”
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Chemogenetic modulation of accumbens direct or indirect pathways bidirectionally alters reinstatement of heroin-seeking in high- but not low-risk rats by O'Neal, Timothy J, Nooney, Marlaena N, Thien, Katie, Ferguson, Susan M

“…Opioid addiction has been declared a public health emergency, with fatal overdoses following relapse reaching epidemic proportions and disease-associated costs…”
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Basal Ganglia Dysfunction Contributes to Physical Inactivity in Obesity by Friend, Danielle M., Devarakonda, Kavya, O’Neal, Timothy J., Skirzewski, Miguel, Papazoglou, Ioannis, Kaplan, Alanna R., Liow, Jeih-San, Guo, Juen, Rane, Sushil G., Rubinstein, Marcelo, Alvarez, Veronica A., Hall, Kevin D., Kravitz, Alexxai V.

“…Obesity is associated with physical inactivity, which exacerbates the health consequences of weight gain. However, the mechanisms that mediate this association…”
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Dopamine D2 receptor signaling on iMSNs is required for initiation and vigor of learned actions by Augustin, Shana M, Loewinger, Gabriel C, O'Neal, Timothy J, Kravitz, Alexxai V, Lovinger, David M

“…Striatal dopamine D2 receptors (D2Rs) are important for motor output. Selective deletion of D2Rs from indirect pathway-projecting medium spiny neurons (iMSNs)…”
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A Conditioned Place Preference for Heroin Is Signaled by Increased Dopamine and Direct Pathway Activity and Decreased Indirect Pathway Activity in the Nucleus Accumbens by O'Neal, Timothy J, Bernstein, Mollie X, MacDougall, Derek J, Ferguson, Susan M

“…Repeated pairing of a drug with a neutral stimulus, such as a cue or context, leads to the attribution of the drug's reinforcing properties to that stimulus,…”
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Lipid hijacking: a unifying theme in vector-borne diseases by O'Neal, Anya J, Butler, L Rainer, Rolandelli, Agustin, Gilk, Stacey D, Pedra, Joao Hf

“…Vector-borne illnesses comprise a significant portion of human maladies, representing 17% of global infections. Transmission of vector-borne pathogens to…”
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A machine learning model identifies patients in need of autoimmune disease testing using electronic health records by Forrest, Iain S., Petrazzini, Ben O., Duffy, Áine, Park, Joshua K., O’Neal, Anya J., Jordan, Daniel M., Rocheleau, Ghislain, Nadkarni, Girish N., Cho, Judy H., Blazer, Ashira D., Do, Ron

“…Systemic autoimmune rheumatic diseases (SARDs) can lead to irreversible damage if left untreated, yet these patients often endure long diagnostic journeys…”
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6-Phosphofructo-2-kinase (PFKFB3) promotes cell cycle progression and suppresses apoptosis via Cdk1-mediated phosphorylation of p27 by Yalcin, A, Clem, B F, Imbert-Fernandez, Y, Ozcan, S C, Peker, S, O'Neal, J, Klarer, A C, Clem, A L, Telang, S, Chesney, J

“…The control of glucose metabolism and the cell cycle must be coordinated in order to guarantee sufficient ATP and anabolic substrates at distinct phases of the…”
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Reply to Nicastri et al by Raabe, Vanessa, O'Neal, J Patrick, Drenzek, Cherie, Kraft, Colleen S

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Ethnic Variations in Cardiovascular and Renal Outcomes From Newer Glucose-Lowering Drugs: A Meta-Analysis of Randomized Outcome Trials by Tang, Huilin, Chen, Weihan, Bian, Jiang, O'Neal, LaToya J, Lackland, Daniel T, Schatz, Desmond A, Guo, Jingchuan

“…Background Hispanic populations are more likely to develop diabetes and its related diseases than non-Hispanic White populations. Little evidence exists to…”
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Synthesis and Characterization of Two Unsymmetrical Indenofluorene Analogues: Benzo[5,6]‑s‑indaceno[1,2‑b]thiophene and Benzo[5,6]‑s‑indaceno[2,1‑b]thiophene by Marshall, Jonathan L, O’Neal, Nathaniel J, Zakharov, Lev N, Haley, Michael M

“…The synthesis and characterization of two benzo-indaceno-thiophene compounds (anti-BIT and syn-BIT) are described. Two sequential Suzuki cross-couplings…”
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p47 licenses activation of the immune deficiency pathway in the tick Ixodes scapularis by Carroll, Erin E. McClure, Wang, Xiaowei, Shaw, Dana K., O’Neal, Anya J., Chávez, Adela S. Oliva, Brown, Lindsey J., Boradia, Vishant Mahendra, Hammond, Holly L., Pedra, Joao H. F.

“…The E3 ubiquitin ligase X-linked inhibitor of apoptosis (XIAP) acts as a molecular rheostat for the immune deficiency (IMD) pathway of the tick Ixodes…”
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Clinical development of cancer therapeutics that target metabolism by Clem, B F, O'Neal, J, Klarer, A C, Telang, S, Chesney, J

“…Glucose and glutamine metabolism in cancer cells are markedly elevated relative to non-transformed normal cells. This metabolic reprogramming enables the…”
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Do Dopaminergic Impairments Underlie Physical Inactivity in People with Obesity? by Kravitz, Alexxai V, O'Neal, Timothy J, Friend, Danielle M

“…Obesity is associated with physical inactivity, which exacerbates the negative health consequences of obesity. Despite a wide consensus that people with…”
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Genetic manipulation of an Ixodes scapularis cell line by Singh, Nisha, Rolandelli, Agustin, O'Neal, Anya J, Butler, L Rainer, Samaddar, Sourabh, Laukaitis-Yousey, Hanna J, Butnaru, Matthew, Mohr, Stephanie E, Perrimon, Norbert, Pedra, Joao H F

“…Although genetic manipulation is one of the hallmarks of model organisms, its applicability to non-model species has remained difficult due to our limited…”
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Message in a vesicle - trans-kingdom intercommunication at the vector-host interface by Chávez, Adela S Oliva, O'Neal, Anya J, Santambrogio, Laura, Kotsyfakis, Michail, Pedra, Joao H F

“…Vector-borne diseases cause over 700,000 deaths annually and represent 17% of all infectious illnesses worldwide. This public health menace highlights the…”
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The Enterovirus Theory of Disease Etiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: A Critical Review by O'Neal, Adam J., Hanson, Maureen R.

“…Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a complex, multi-system disease whose etiological basis has not been established. Enteroviruses…”
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Increases in Physical Activity Result in Diminishing Increments in Daily Energy Expenditure in Mice by O’Neal, Timothy J., Friend, Danielle M., Guo, Juen, Hall, Kevin D., Kravitz, Alexxai V.

“…Exercise is a common component of weight loss strategies, yet exercise programs are associated with surprisingly small changes in body weight [1–4]. This may…”
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Regionally adaptable dNBR-based algorithm for burned area mapping from MODIS data by Loboda, T., O'Neal, K.J., Csiszar, I.

“…Recent advances in instrument design have led to considerable improvements in wildfire mapping at regional and global scales. Global and regional active fire…”
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Single-shot structural analysis by high-energy X-ray diffraction using an ultrashort all-optical source by Rakowski, R., Golovin, G., O’Neal, J., Zhang, J., Zhang, P., Zhao, B., Wilson, M. D., Veale, M. C., Seller, P., Chen, S., Banerjee, S., Umstadter, D., Fuchs, M.

“…High-energy X-rays (HEX-rays) with photon energies on order of 100 keV have attractive characteristics, such as comparably low absorption, high spatial…”
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