Search Results - "O’Meara, Gillian"

Susceptibility genes for schizophrenia: Characterisation of mutant mouse models at the level of phenotypic behaviour by O’Tuathaigh, Colm M.P., Babovic, Daniela, O’Meara, Gillian, Clifford, Jeremiah J., Croke, David T., Waddington, John L.

“…A wealth of evidence indicates that schizophrenia is heritable. However, the genetic mechanisms involved are poorly understood. Furthermore, it may be that…”
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Sedation and Anesthesia Mediated by Distinct GABAA Receptor Isoforms by Reynolds, David S, Rosahl, Thomas W, Cirone, Jennifer, O'Meara, Gillian F, Haythornthwaite, Alison, Newman, Richard J, Myers, Janice, Sur, Cyrille, Howell, Owain, Rutter, A. Richard, Atack, John, Macaulay, Alison J, Hadingham, Karen L, Hutson, Peter H, Belelli, Delia, Lambert, Jeremy J, Dawson, Gerard R, McKernan, Ruth, Whiting, Paul J, Wafford, Keith A

“…The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABA A…”
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Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms by Reynolds, David S, Rosahl, Thomas W, Cirone, Jennifer, O'Meara, Gillian F, Haythornthwaite, Alison, Newman, Richard J, Myers, Janice, Sur, Cyrille, Howell, Owain, Rutter, A Richard, Atack, John, Macaulay, Alison J, Hadingham, Karen L, Hutson, Peter H, Belelli, Delia, Lambert, Jeremy J, Dawson, Gerard R, McKernan, Ruth, Whiting, Paul J, Wafford, Keith A

“…The specific mechanisms underlying general anesthesia are primarily unknown. The intravenous general anesthetic etomidate acts by potentiating GABA(A)…”
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Differential contribution of GABAA receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L., Guscott, Martin R., Bull, Sharlene, Hallett, David J., Goodacre, Simon C., Wafford, Keith A., Garrett, ELizabeth M., Newman, Richard J., O'Meara, Gillian F., Whiting, Paul J., Rosahl, Thomas W., Dawson, Gerard R., Reynolds, David S., Atack, John R.

“…Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABAA receptors containing either an α1, α2, α3 or…”
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Differential contribution of GABA(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L, Guscott, Martin R, Bull, Sharlene, Hallett, David J, Goodacre, Simon C, Wafford, Keith A, Garrett, Elizabeth M, Newman, Richard J, O'Meara, Gillian F, Whiting, Paul J, Rosahl, Thomas W, Dawson, Gerard R, Reynolds, David S, Atack, John R

“…Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA(A) receptors containing either an alpha1,…”
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γ-Aminobutyric acid type A receptor β2 subunit mediates the hypothermic effect of etomidate in mice by CIRONE, Jennifer, ROSAHL, Thomas W, REYNOLDS, David S, NEWMAN, Richard J, O'MEARA, Gillian F, HUTSON, Peter H, WAFFORD, Keith A

“…Background The authors have previously described that the gamma-aminobutyric acid type A (GABAA) receptor beta 2N265S mutation results in a knock-in mouse with…”
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The GABA-A β3 subunit mediates anaesthesia induced by etomidate by OʼMeara, Gillian F, Newman, Richard J, Fradley, Rosa L, Dawson, Gerard R, Reynolds, David S

“…The i.v. agent etomidate exerts its anaesthetic actions through potentiation of γ-aminobutyric acid-A receptors containing β2 and β3 subunits. It was recently…”
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Galanin Regulates the Postnatal Survival of a Subset of Basal Forebrain Cholinergic Neurons by O'Meara, Gillian, Coumis, Urania, Ma, Shuang Y., Kehr, Jan, Mahoney, Sally, Bacon, Andrea, Allen, Shelley J., Holmes, Fiona, Kahl, Ulrika, Wang, Fu H., Kearns, Ian R., Ove-Ogren, Sven, Dawbarn, David, Mufson, Elliott J., Davies, Ceri, Dawson, Gerard, Wynick, David

“…The neuropeptide galanin colocalizes with choline acetyltransferase, the synthetic enzyme for acetylcholine, in a subset of cholinergic neurons in the basal…”
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STOP knockout and NMDA NR1 hypomorphic mice exhibit deficits in sensorimotor gating by Fradley, Rosa L., O’Meara, Gillian F., Newman, Richard J., Andrieux, Annie, Job, Didier, Reynolds, David S.

“…Schizophrenia is a chronic and debilitating disease which is thought to arise from a neuro-developmental disorder. Both the stable tubule-only polypeptide…”
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Potential and limitations of genetic manipulation in animals by O'Sullivan, Gerard J., O’Tuathaigh, Colm M., Clifford, Jeremiah J., O’Meara, Gillian F., Croke, David T., Waddington, John L.

“…Over the last decade, sequencing and characterisation of the mouse genome has been accompanied by unparalleled advances in functional genomics. In the context…”
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Loss of the Major GABAA Receptor Subtype in the Brain Is Not Lethal in Mice by Sur, Cyrille, Wafford, Keith A, Reynolds, David S, Hadingham, Karen L, Bromidge, Frances, Macaulay, Alison, Collinson, Neil, O'Meara, Gillian, Howell, Owain, Newman, Richard, Myers, Janice, Atack, John R, Dawson, Gerard R, McKernan, Ruth M, Whiting, Paul J, Rosahl, Thomas W

“…The α1β2γ2 is the most abundant subtype of the GABA A receptor and is localized in many regions of the brain. To gain more insight into the role of this…”
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Loss of the major GABA(A) receptor subtype in the brain is not lethal in mice by Sur, C, Wafford, K A, Reynolds, D S, Hadingham, K L, Bromidge, F, Macaulay, A, Collinson, N, O'Meara, G, Howell, O, Newman, R, Myers, J, Atack, J R, Dawson, G R, McKernan, R M, Whiting, P J, Rosahl, T W

“…The alpha1beta2gamma2 is the most abundant subtype of the GABA(A) receptor and is localized in many regions of the brain. To gain more insight into the role of…”
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Susceptibility genes for schizophrenia : Characterisation of mutant mouse models at the level of phenotypic behaviour: Neurogenetics and behavior by O'TUATHAIGH, Colm M. P, BABOVIC, Daniela, O'MEARA, Gillian, CLIFFORD, Jeremiah J, CROKE, David T, WADDINGTON, John L

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Gamma-aminobutyric acid type A receptor beta 2 subunit mediates the hypothermic effect of etomidate in mice by Cirone, Jennifer, Rosahl, Thomas W, Reynolds, David S, Newman, Richard J, O'Meara, Gillian F, Hutson, Peter H, Wafford, Keith A

“…The authors have previously described that the gamma-aminobutyric acid type A (GABAA) receptor beta 2N265S mutation results in a knock-in mouse with reduced…”
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The GABA-A beta3 subunit mediates anaesthesia induced by etomidate by O'Meara, Gillian F, Newman, Richard J, Fradley, Rosa L, Dawson, Gerard R, Reynolds, David S

“…The i.v. agent etomidate exerts its anaesthetic actions through potentiation of gamma-aminobutyric acid-A receptors containing beta2 and beta3 subunits. It was…”
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Differential contribution of GAB[A.sub.A] receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L, Guscott, Ma, Bull, Sharlene, Hallett, David J, Goodacre, Simon C, Wafford, Keith A, Garrett, Elizabeth M, Newman, Richard J, O'Meara, Gillian F, Whiting, Paul J, Rosahl, Thomas W, Dawson, Gerard R, Reynolds, David S, Atack, John R

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Differential contribution of GABA sub(A) receptor subtypes to the anticonvulsant efficacy of benzodiazepine site ligands by Fradley, Rosa L, Guscott, Martin R, Bull, Sharlene, Hallett, David J, Goodacre, Simon C, Wafford, Keith A, Garrett, ELizabeth M, Newman, Richard J, O'Meara, Gillian F, Whiting, Paul J, Rosahl, Thomas W, Dawson, Gerard R, Reynolds, David S, Atack, John R

“…Non-selective benzodiazepines, such as diazepam, interact with equivalent affinity and agonist efficacy at GABA sub(A) receptors containing either an a1, a2,…”
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