Search Results - "O’Meara, Caitlin C."

The Evolving Roles of Cardiac Macrophages in Homeostasis, Regeneration, and Repair by Alvarez-Argote, Santiago, O’Meara, Caitlin C.

“…Macrophages were first described as phagocytic immune cells responsible for maintaining tissue homeostasis by the removal of pathogens that disturb normal…”
Get full text

Transcriptional Reversion of Cardiac Myocyte Fate During Mammalian Cardiac Regeneration by O’Meara, Caitlin C, Wamstad, Joseph A, Gladstone, Rachel A, Fomovsky, Gregory M, Butty, Vincent L, Shrikumar, Avanti, Gannon, Joseph B, Boyer, Laurie A, Lee, Richard T

“…RATIONALE:Neonatal mice have the capacity to regenerate their hearts in response to injury, but this potential is lost after the first week of life. The…”
Get full text

Interleukin 4/13 signaling in cardiac regeneration and repair by Bakhshian Nik, Amirala, Alvarez-Argote, Santiago, O'Meara, Caitlin C

“…Interleukin 4 (IL4) and interleukin 13 (IL13) are closely related cytokines that have been classically attributed to type II immunity, namely, differentiation…”
Get more information

Upstream regulation of the Hippo-Yap pathway in cardiomyocyte regeneration by Flinn, Michael A., Link, Brian A., O’Meara, Caitlin C.

“…The response of the adult mammalian heart to injury such as myocardial infarction has long been described as primarily fibrotic scarring and adverse remodeling…”
Get full text

IL-13 promotes in vivo neonatal cardiomyocyte cell cycle activity and heart regeneration by Wodsedalek, Dylan J, Paddock, Samantha J, Wan, Tina C, Auchampach, John A, Kenarsary, Aria, Tsaih, Shirng-Wern, Flister, Michael J, O'Meara, Caitlin C

“…There is great interest in identifying signaling mechanisms by which cardiomyocytes (CMs) can enter the cell cycle and promote endogenous cardiac repair. We…”
Get more information

Steps toward therapeutically targeting the activin type II receptor for treating heart failure by Paddock, Samantha J, O'Meara, Caitlin C

Get more information

Global IL4Rα blockade exacerbates heart failure after an ischemic event in mice and humans by Alvarez-Argote, Santiago, Almeida, Victor A, Knas, Makenna C, Buday, Sydney L, Patterson, Michaela, O'Meara, Caitlin C

“…Ischemic heart failure continues to be a highly prevalent disease among westernized countries and there is great interest in understanding the mechanisms…”
Get more information

Measuring cardiomyocyte cell-cycle activity and proliferation in the age of heart regeneration by Auchampach, John, Han, Lu, Huang, Guo N, Kühn, Bernhard, Lough, John W, O'Meara, Caitlin C, Payumo, Alexander Y, Rosenthal, Nadia A, Sucov, Henry M, Yutzey, Katherine E, Patterson, Michaela

“…During the past two decades, the field of mammalian myocardial regeneration has grown dramatically, and with this expanded interest comes increasing claims of…”
Get more information

IL4Rα signaling promotes neonatal cardiac regeneration and cardiomyocyte cell cycle activity by Paddock, Samantha J., Swift, Samantha K., Alencar-Almeida, Victor, Kenarsary, Aria, Alvarez-Argote, Santiago, Flinn, Michael A., Patterson, Michaela, O'Meara, Caitlin C.

“…Neonatal heart regeneration depends on proliferation of pre-existing cardiomyocytes, yet the mechanisms driving regeneration and cardiomyocyte proliferation…”
Get full text

Reperfused vs. nonreperfused myocardial infarction: when to use which model by Lindsey, Merry L, de Castro Brás, Lisandra E, DeLeon-Pennell, Kristine Y, Frangogiannis, Nikolaos G, Halade, Ganesh V, O'Meara, Caitlin C, Spinale, Francis G, Kassiri, Zamaneh, Kirk, Jonathan A, Kleinbongard, Petra, Ripplinger, Crystal M, Brunt, Keith R

“…There is a lack of understanding in the cardiac remodeling field regarding the use of nonreperfused myocardial infarction (MI) and reperfused MI in animal…”
Get more information

Runx1 is sufficient but not required for cardiomyocyte cell-cycle activation by Akins, Kaelin A, Flinn, Michael A, Swift, Samantha K, Chanjeevaram, Smrithi V, Purdy, Alexandra L, Buddell, Tyler, Kolell, Mary E, Andresen, Kaitlyn G, Paddock, Samantha, Buday, Sydney L, Veldman, Matthew B, O'Meara, Caitlin C, Patterson, Michaela

“…Factors responsible for cardiomyocyte proliferation could serve as potential therapeutics to stimulate endogenous myocardial regeneration following insult,…”
Get more information

Identifying multiple causative genes at a single GWAS locus by Flister, Michael J, Tsaih, Shirng-Wern, O'Meara, Caitlin C, Endres, Bradley, Hoffman, Matthew J, Geurts, Aron M, Dwinell, Melinda R, Lazar, Jozef, Jacob, Howard J, Moreno, Carol

“…Genome-wide association studies (GWAS) are useful for nominating candidate genes, but typically are unable to establish disease causality or differentiate…”
Get full text

Cardiac myosin binding protein C regulates postnatal myocyte cytokinesis by Jiang, Jianming, Patrick G. Burgon, Hiroko Wakimoto, Kenji Onoue, Joshua M. Gorham, Caitlin C. O’Meara, Gregory Fomovsky, Bradley K. McConnell, Richard T. Lee, J. G. Seidman, Christine E. Seidman

“…Homozygous cardiac myosin binding protein C-deficient (Mybpc ᵗ/ᵗ) mice develop dramatic cardiac dilation shortly after birth; heart size increases almost…”
Get full text

Llgl1 regulates zebrafish cardiac development by mediating Yap stability in cardiomyocytes by Flinn, Michael A, Otten, Cécile, Brandt, Zachary J, Bostrom, Jonathan R, Kenarsary, Aria, Wan, Tina C, Auchampach, John A, Abdelilah-Seyfried, Salim, O'Meara, Caitlin C, Link, Brian A

“…The Hippo-Yap pathway regulates multiple cellular processes in response to mechanical and other stimuli. In , the polarity protein Lethal (2) giant larvae…”
Get full text

Shroom3 contributes to the maintenance of the glomerular filtration barrier integrity by Yeo, Nan Cher, O'Meara, Caitlin C, Bonomo, Jason A, Veth, Kerry N, Tomar, Ritu, Flister, Michael J, Drummond, Iain A, Bowden, Donald W, Freedman, Barry I, Lazar, Jozef, Link, Brian A, Jacob, Howard J

“…Genome-wide association studies (GWAS) identify regions of the genome correlated with disease risk but are restricted in their ability to identify the…”
Get full text

Collagen-Specific HSP47 + Myofibroblasts and CD163 + Macrophages Identify Profibrotic Phenotypes in Deceased Hearts With SARS-CoV-2 Infections by Puzyrenko, Andrii, Jacobs, Elizabeth R, Padilla, Nathan, Devine, Adam, Aljadah, Michael, Gantner, Benjamin N, Pan, Amy Y, Lai, Shuping, Dai, Qiang, Rubenstein, Jason C, North, Paula E, Simpson, Pippa M, Willoughby, Rodney E, O'Meara, Caitlin C, Flinn, Michael A, Lough, John W, Ibrahim, El-Sayed H, Zheng, Ze, Sun, Yunguang, Felix, Juan, Hunt, Bryan C, Ross, Gracious, Rui, Hallgeir, Benjamin, Ivor J

“…Background Cardiac fibrosis complicates SARS-CoV-2 infections and has been linked to arrhythmic complications in survivors. Accordingly, we sought evidence of…”
Get full text

SH2B3 Is a Genetic Determinant of Cardiac Inflammation and Fibrosis by Flister, Michael J, Hoffman, Matthew J, Lemke, Angela, Prisco, Sasha Z, Rudemiller, Nathan, O’Meara, Caitlin C, Tsaih, Shirng-Wern, Moreno, Carol, Geurts, Aron M, Lazar, Jozef, Adhikari, Neeta, Hall, Jennifer L, Jacob, Howard J

“…BACKGROUND—Genome-wide association studies are powerful tools for nominating pathogenic variants, but offer little insight as to how candidate genes affect…”
Get full text

A broadly applicable method for quantifying cardiomyocyte cell division identifies proliferative events following myocardial infarction by Swift, Samantha K., Purdy, Alexandra L., Buddell, Tyler, Lovett, Jerrell J., Chanjeevaram, Smrithi V., Arkatkar, Anooj, O’Meara, Caitlin C., Patterson, Michaela

“…Cardiomyocyte proliferation is a challenging metric to assess. Current methodologies have limitations in detecting the generation of new cardiomyocytes and…”
Get full text

Myofibroblast Ccn3 is regulated by Yap and Wwtr1 and contributes to adverse cardiac outcomes by Flinn, Michael A, Alvarez-Argote, Santiago, Knas, Makenna C, Almeida, Victor Alencar, Paddock, Samantha J, Zhou, Xiaoxu, Buddell, Tyler, Jamal, Ayana, Taylor, Reiauna, Liu, Pengyuan, Drnevich, Jenny, Patterson, Michaela, Link, Brian A, O'Meara, Caitlin C

“…While Yap and Wwtr1 regulate resident cardiac fibroblast to myofibroblast differentiation following cardiac injury, their role specifically in activated…”
Get full text

IL-13 promotes functional recovery after myocardial infarction via direct signaling to macrophages by Alvarez-Argote, Santiago, Paddock, Samantha J, Flinn, Michael A, Moreno, Caelan W, Knas, Makenna C, Almeida, Victor A, Buday, Sydney L, Bakhshian Nik, Amirala, Patterson, Michaela, Chen, Yi-Guang, Lin, Chien-Wei, O'Meara, Caitlin C

“…There is great interest in identifying signaling pathways that promote cardiac repair after myocardial infarction (MI). Prior studies suggest a beneficial role…”
Get full text