Search Results - "O’Mara, Megan L."

Mechanism of Activation of Protein Kinase JAK2 by the Growth Hormone Receptor by Brooks, Andrew J., Dai, Wei, O'Mara, Megan L., Abankwa, Daniel, Chhabra, Yash, Pelekanos, Rebecca A., Gardon, Olivier, Tunny, Kathryn A., Blucher, Kristopher M., Morton, Craig J., Parker, Michael W., Sierecki, Emma, Gambin, Yann, Gomez, Guillermo A., Alexandrov, Kirill, Wilson, Ian A., Doxastakis, Manolis, Mark, Alan E., Waters, Michael J.

“…Signaling from JAK (Janus kinase) protein kinases to STAT (signal transducers and activators of transcription) transcription factors is key to many aspects of…”
Get full text

The ryanodine receptor store-sensing gate controls Ca2+ waves and Ca2+-triggered arrhythmias by Chen, Wenqian, Wang, Ruiwu, Chen, Biyi, Zhong, Xiaowei, Kong, Huihui, Bai, Yunlong, Zhou, Qiang, Xie, Cuihong, Zhang, Jingqun, Guo, Ang, Tian, Xixi, Jones, Peter P, O'Mara, Megan L, Liu, Yingjie, Mi, Tao, Zhang, Lin, Bolstad, Jeff, Semeniuk, Lisa, Cheng, Hongqiang, Zhang, Jianlin, Chen, Ju, Tieleman, D Peter, Gillis, Anne M, Duff, Henry J, Fill, Michael, Song, Long-Sheng, Chen, S R Wayne

“…In heart muscle cells, sarcoplasmic reticulum calcium overload leads to spontaneous calcium waves that can cause arrhythmias and sudden cardiac death. S.R…”
Get full text

Multidrug Resistance in Neisseria gonorrhoeae: Identification of Functionally Important Residues in the MtrD Efflux Protein by Chitsaz, Mohsen, Booth, Lauren, Blyth, Mitchell T, O'Mara, Megan L, Brown, Melissa H

“…A key mechanism that uses to achieve multidrug resistance is the expulsion of structurally different antimicrobials by the MtrD multidrug efflux protein. MtrD…”
Get full text

High resolution crystal structure of a KRAS promoter G-quadruplex reveals a dimer with extensive poly-A π-stacking interactions for small-molecule recognition by Ou, Arnold, Schmidberger, Jason W, Wilson, Katie A, Evans, Cameron W, Hargreaves, Jessica A, Grigg, Melanie, O'Mara, Megan L, Iyer, K Swaminathan, Bond, Charles S, Smith, Nicole M

“…Aberrant KRAS signaling is a driver of many cancers and yet remains an elusive target for drug therapy. The nuclease hypersensitive element of the KRAS…”
Get full text

Synthetically controlling dendrimer flexibility improves delivery of large plasmid DNA by Kretzmann, Jessica A, Ho, Diwei, Evans, Cameron W, Plani-Lam, Janice H C, Garcia-Bloj, Benjamin, Mohamed, A Elaaf, O'Mara, Megan L, Ford, Ethan, Tan, Dennis E K, Lister, Ryan, Blancafort, Pilar, Norret, Marck, Iyer, K Swaminathan

“…Tools for editing the genome and epigenome have revolutionised the field of molecular biology and represent a new frontier in targeted therapeutic…”
Get full text

Imperfect coordination chemistry facilitates metal ion release in the Psa permease by Couñago, Rafael M, Ween, Miranda P, Begg, Stephanie L, Bajaj, Megha, Zuegg, Johannes, O'Mara, Megan L, Cooper, Matthew A, McEwan, Alastair G, Paton, James C, Kobe, Bostjan, McDevitt, Christopher A

“…The PsaA binding protein delivers Mn 2+ to the human pathogen Streptococcus pneumoniae . Structural and biochemical studies now explain its metal specificity,…”
Get full text

AdcA and AdcAII employ distinct zinc acquisition mechanisms and contribute additively to zinc homeostasis in Streptococcus pneumoniae by Plumptre, Charles D., Eijkelkamp, Bart A., Morey, Jacqueline R., Behr, Felix, Couñago, Rafael M., Ogunniyi, Abiodun D., Kobe, Bostjan, O'Mara, Megan L., Paton, James C., McDevitt, Christopher A.

“…Summary Streptococcus pneumoniae is a globally significant human pathogen responsible for nearly 1 million deaths annually. Central to the ability of S…”
Get full text

Location of contact residues in pharmacologically distinct drug binding sites on P-glycoprotein by Mittra, Rituparna, Pavy, Megan, Subramanian, Nanditha, George, Anthony M., O'Mara, Megan L., Kerr, Ian D., Callaghan, Richard

“…[Display omitted] The multidrug resistance P-glycoprotein (P-gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This…”
Get full text

Hydrophobic Shielding Drives Catalysis of Hydride Transfer in a Family of F420H2‑Dependent Enzymes by Mohamed, A. Elaaf, Condic-Jurkic, Karmen, Ahmed, F. Hafna, Yuan, Peng, O’Mara, Megan L, Jackson, Colin J, Coote, Michelle L

“…A family of flavin/deazaflavin-dependent oxidoreductases (FDORs) from mycobacteria has been recently characterized and found to play a variety of catalytic…”
Get full text

mechanism of ABC transporters: general lessons from structural and functional studies of an antigenic peptide transporter by Procko, Erik, O'Mara, Megan L, Bennett, W.F. Drew, Tieleman, D. Peter, Gaudet, Rachelle

“…The shuttling of substrates across a cellular membrane frequently requires a specialized ATP-binding cassette (ABC) transporter, which couples the energy of…”
Get full text

Rv2074 is a novel F420H2‐dependent biliverdin reductase in Mycobacterium tuberculosis by Ahmed, F. Hafna, Mohamed, A. Elaaf, Carr, Paul D., Lee, Brendon M., Condic‐Jurkic, Karmen, O'Mara, Megan L., Jackson, Colin J.

“…Bilirubin is a potent antioxidant that is produced from the reduction of the heme degradation product biliverdin. In mammalian cells and Cyanobacteria,…”
Get full text

The Effect of Environment on the Recognition and Binding of Vancomycin to Native and Resistant Forms of Lipid II by Jia, ZhiGuang, O'Mara, Megan L., Zuegg, Johannes, Cooper, Matthew A., Mark, Alan E.

“…Molecular dynamics simulations and free energy calculations have been used to examine in detail the mechanism by which a receptor molecule (the glycopeptide…”
Get full text

Hydrogen bond‐Driven Self–Assembly between Amidinium Cations and Carboxylate Anions: A Combined Molecular Dynamics, NMR Spectroscopy, and Single Crystal X‐ray Diffraction Study by Thomas, Michael, Anglim Lagones, Thomas, Judd, Martyna, Morshedi, Mahbod, O'Mara, Megan L., White, Nicholas G.

“…A combination of molecular dynamics (MD), NMR spectroscopy, and single crystal X‐ray diffraction (SCXRD) techniques was used to probe the self–assembly of…”
Get full text

Conserved FimH mutations in the global Escherichia coli ST131 multi-drug resistant lineage weaken interdomain interactions and alter adhesin function by Qin, Jilong, Wilson, Katie A., Sarkar, Sohinee, Heras, Begoña, O'Mara, Megan L., Totsika, Makrina

“…[Display omitted] The binding of the type 1 fimbrial adhesin FimH to mannosylated receptors is allosterically regulated to enhance the fitness of uropathogenic…”
Get full text

Membrane cholesterol regulates inhibition and substrate transport by the glycine transporter, GlyT2 by Frangos, Zachary J, Wilson, Katie A, Aitken, Heather M, Cantwell Chater, Ryan, Vandenberg, Robert J, O'Mara, Megan L

“…Membrane cholesterol binds to and modulates the function of various SLC6 neurotransmitter transporters, including stabilizing the outward-facing conformation…”
Get full text

Investigating the lipid fingerprint of SLC6 neurotransmitter transporters: a comparison of dDAT, hDAT, hSERT, and GlyT2 by Wilson, Katie A., Wang, Lily, Lin, Yie Chang, O'Mara, Megan L.

“…•Lipid fingerprints are comprised of similar lipid classes•Sites of specific lipid contacts, including CHOL, varies between transporters•Changes in lipid…”
Get full text

Structural arrangement of the transmission interface in the antigen ABC transport complex TAP by Oancea, Giani, O'Mara, Megan L, Bennett, W.F. Drew, Tieleman, D. Peter, Abele, Rupert, Tampé, Robert

“…The transporter associated with antigen processing (TAP) represents a focal point in the immune recognition of virally or malignantly transformed cells by…”
Get full text

Effect of the Force Field on Molecular Dynamics Simulations of the Multidrug Efflux Protein P‑Glycoprotein by Wang, Lily, O’Mara, Megan L

“…Molecular dynamics (MD) simulations have been used extensively to study P-glycoprotein (P-gp), a flexible multidrug transporter that is a key player in the…”
Get full text

The effects of oxidised phospholipids and cholesterol on the biophysical properties of POPC bilayers by Schumann-Gillett, Alexandra, O'Mara, Megan L.

“…Oxidation of unsaturated membrane phospholipids by oxidative stress is associated with inflammation, infection, numerous diseases and neurodegenerative…”
Get full text

Main‐chain Macromolecular Hydrazone Photoswitches by Thai, Linh Duy, Fanelli, Julian, Munaweera, Rangika, O'Mara, Megan L., Barner‐Kowollik, Christopher, Mutlu, Hatice

“…Hydrazones—consisting of a dynamic imine bond and an acidic NH proton—have recently emerged as versatile photoswitches underpinned by their ability to form…”
Get full text