Search Results - "O’Mahony, Donogh J.R."

Identification of orally-bioavailable antagonists of the TRPV4 ion-channel by Wei, Zhi-Liang, Nguyen, Margaret T., O’Mahony, Donogh J.R., Acevedo, Alejandra, Zipfel, Sheila, Zhang, Qingling, Liu, Luna, Dourado, Michelle, Chi, Candace, Yip, Victor, DeFalco, Jeff, Gustafson, Amy, Emerling, Daniel E., Kelly, Michael G., Kincaid, John, Vincent, Fabien, Duncton, Matthew A.J.

“…[Display omitted] Antagonists of the TRPV4 receptor were identified using a focused screen, followed by a limited optimization program. The leading compounds…”
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Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity by Shiau, Timothy P., Low, Eddy, Kim, Bum, Turtle, Eric D., Francavilla, Charles, O’Mahony, Donogh J.R., Friedman, Lisa, D’Lima, Louisa, Jekle, Andreas, Debabov, Dmitri, Zuck, Meghan, Alvarez, Nichole J., Anderson, Mark, Najafi, Ramin (Ron), Jain, Rakesh K.

“…Polyol-solubilized 3-(dichloroamino)-3-methylbutylsulfones 1a–m and sulfonamides 2a–b show fast-acting, broad spectrum antimicrobial activity against bacterial…”
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Novel N-chloroheterocyclic antimicrobials by Francavilla, Charles, Turtle, Eric D., Kim, Bum, O’Mahony, Donogh J.R., Shiau, Timothy P., Low, Eddy, Alvarez, Nichole J., Celeri, Chris E., D’Lima, Louisa, Friedman, Lisa C., Ruado, Francis S., Xu, Ping, Zuck, Meghan E., Anderson, Mark B., Najafi, Ramin (Ron), Jain, Rakesh K.

“…A novel series of N-chloroheterocycles has been prepared and the biological properties are reported. Antimicrobial compounds with broad-spectrum activity and…”
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Thermal promotion of the cobalt catalyzed intramolecular Pauson-Khand reaction — An alternative experimental protocol for cyclopentenone synthesis by Belanger, David B., O'Mahony, Donogh J.R., Livinghouse, Tom

“…Heat alone has been found sufficient to promote intramolecular Pauson-Khand cyclizations catalyzed by high purity Co 2(CO) 8. The existence of a very narrow…”
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Novel 3-chlorooxazolidin-2-ones as antimicrobial agents by Shiau, Timothy P., Turtle, Eric D., Francavilla, Charles, Alvarez, Nichole J., Zuck, Meghan, Friedman, Lisa, O’Mahony, Donogh J.R., Low, Eddy, Anderson, Mark B., Najafi, Ramin (Ron), Jain, Rakesh K.

“…Antimicrobial resistance against many known therapeutics is on the rise. We examined derivatives of 3-chlorooxazolidin-2-one 1a (X = H) as antibacterial and…”
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Structure stability/activity relationships of sulfone stabilized N, N-dichloroamines by Low, Eddy, Kim, Bum, Francavilla, Charles, Shiau, Timothy P., Turtle, Eric D., O’Mahony, Donogh J.R., Alvarez, Nichole, Houchin, Ashley, Xu, Ping, Zuck, Meghan, Celeri, Chris, Anderson, Mark B., Najafi, Ramin (Ron), Jain, Rakesh K.

“…This study identified a new class of solution-stable, topical, antimicrobial agents. These agents are sulfone-stabilized and possess either a quaternary…”
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A practical asymmetric synthesis of ortho-substituted 4-pyrazolyl-2-ethylamines by O'Mahony, Donogh J.R., Johnson, Russell J., Estiarte, M. Angels, Edwards, William T., Duncton, Matthew A.J.

“…[Display omitted] •An asymmetric synthesis of ortho-substituted 4-pyrazolyl-2-ethylamines.•The synthesis employs Ellman’s tert-butanesulfinamine chiral…”
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Preparation of Heteroaryloxetanes and Heteroarylazetidines by Use of a Minisci Reaction by Duncton, Matthew A. J, Estiarte, M. Angels, Johnson, Russell J, Cox, Matthew, O’Mahony, Donogh J. R, Edwards, William T, Kelly, Michael G

“…Introduction of oxetan-3-yl and azetidin-3-yl groups into heteroaromatic bases was achieved by using a radical addition method (Minisci reaction). To…”
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Preparation of Aryloxetanes and Arylazetidines by Use of an Alkyl−Aryl Suzuki Coupling by Duncton, Matthew A. J, Estiarte, M. Angels, Tan, Darlene, Kaub, Carl, O’Mahony, Donogh J. R, Johnson, Russell J, Cox, Matthew, Edwards, William T, Wan, Min, Kincaid, John, Kelly, Michael G

“…The oxetan-3-yl and azetidin-3-yl substituents have previously been identified as privileged motifs within medicinal chemistry. An efficient approach to…”
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Traceless synthesis of 3H-quinazolin-4-ones via a combination of solid-phase and solution methodologies by O'Mahony, Donogh J.R., Krchňák, Viktor

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A concise one-pot synthesis of trifluoromethyl-containing 2,6-disubstituted 5,6,7,8-tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines by Johnson, Russell J, O'Mahony, Donogh J R, Edwards, William T, Duncton, Matthew A J

“…5,6,7,8-Tetrahydroquinolines and 5,6,7,8-tetrahydronaphthyridines with appended trifluoromethyl groups are valuable chemotypes in medicinal chemistry due to…”
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Traceless synthesis of 3 H-quinazolin-4-ones via a combination of solid-phase and solution methodologies by O'Mahony, Donogh J.R., Krchňák, Viktor

“…A solid-phase traceless synthesis of quinazolin-4-ones is described. An aldehyde functionalized resin was reductively aminated with primary amines, and the…”
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A single-step preparation of thiazolo[5,4-b]pyridine- and thiazolo[5,4-c]pyridine derivatives from chloronitropyridines and thioamides, or thioureas by Sahasrabudhe, Kiran P., Angels Estiarte, M., Tan, Darlene, Zipfel, Sheila, Cox, Matthew, O'Mahony, Donogh J. R., Edwards, William T., Duncton, Matthew A. J.

“…A one‐step synthesis of thiazolo[5,4‐b]pyridines from an appropriately substituted chloronitropyridine and thioamide, or thiourea, is presented. In particular,…”
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Observations on the generation of organozinc carbenoids from acetals and ketals by Motherwell, William B., O'Mahony, Donogh J.R., Popkin, Matthew E.

“…The use of acetals and ketals as direct precursors for organozinc carbenoid chemistry is illustrated by their direct conversion to alkenes in a one pot…”
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