Search Results - "O’Leary, Valerie Bríd"

Enhanced Extracellular Transfer of HLA-DQ Activates CD3 + Lymphocytes towards Compromised Treg Induction in Celiac Disease by Hudec, Michael, Juříčková, Iva, Riegerová, Kamila, Ovsepian, Saak V, Černá, Marie, O'Leary, Valerie Bríd

“…Celiac disease (CeD) manifests with autoimmune intestinal inflammation from gluten and genetic predisposition linked to human leukocyte antigen class-II…”
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Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) by O’Leary, Valerie Bríd, Ovsepian, Saak Victor

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PARTICLE - a triplex-forming long ncRNA regulates locus specific methylation in response to low dose irradiation by O'Leary, Valerie Bríd, Ovsepian, Saak Victor, Carrascosa, Laura Garcia, Buske, Fabian Andreas, Radulovic, Vanja, Niyazi, Maximilian, Moertl, Simone, Trau, Matt, Atkinson, MichaelJohn, Anastasov, Nataša

“…Exposure to low dose irradiation causes transiently elevated expression of a long ncRNA PARTICLE (Gene PARTICL- 'Promoter of MAT2A-Antisense RadiaTion Induced…”
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Unpacking Pandora From Its Box: Deciphering the Molecular Basis of the SARS-CoV-2 Coronavirus by O'Leary, Valerie Bríd, Dolly, Oliver James, Höschl, Cyril, Černa, Marie, Ovsepian, Saak Victor

“…An enigmatic localized pneumonia escalated into a worldwide COVID-19 pandemic from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). This review…”
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Can Arginase Inhibitors Be the Answer to Therapeutic Challenges in Alzheimer's Disease? by Ovsepian, Saak Victor, O'Leary, Valerie Bríd

“…While the extensive hunt for therapeutics combating Alzheimer's disease (AD) has fallen short of delivering effective treatments, breakthroughs towards…”
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lncRNA Biomarkers of Glioblastoma Multiforme by Pokorná, Markéta, Černá, Marie, Boussios, Stergios, Ovsepian, Saak V, O'Leary, Valerie Bríd

“…Long noncoding RNAs (lncRNAs) are RNA molecules of 200 nucleotides or more in length that are not translated into proteins. Their expression is…”
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PARTICLE triplexes cluster in the tumor suppressor WWOX and may extend throughout the human genome by O’Leary, Valerie Bríd, Smida, Jan, Buske, Fabian Andreas, Carrascosa, Laura Garcia, Azimzadeh, Omid, Maugg, Doris, Hain, Sarah, Tapio, Soile, Heidenreich, Wolfgang, Kerr, James, Trau, Matt, Ovsepian, Saak Victor, Atkinson, Michael John

“…The long non-coding RNA PARTICLE (Gene PARTICL - ‘ P romoter of MAT2A - A ntisense R adia T ion I nduced C irculating L ncRNA) partakes in triple helix…”
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Long non-coding RNA PARTICLE bridges histone and DNA methylation by O’Leary, Valerie Bríd, Hain, Sarah, Maugg, Doris, Smida, Jan, Azimzadeh, Omid, Tapio, Soile, Ovsepian, Saak Victor, Atkinson, Michael John

“…PARTICLE (Gene PARTICL - ‘ P romoter of MAT2A - A ntisense R adia T ion I nduced C irculating L ncRNA) expression is transiently elevated following low dose…”
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Biomolecules to Biomarkers? U87MG Marker Evaluation on the Path towards Glioblastoma Multiforme Pathogenesis by Pokorná, Markéta, Kútna, Viera, Ovsepian, Saak V, Matěj, Radoslav, Černá, Marie, O'Leary, Valerie Bríd

“…The heterogeneity of the glioma subtype glioblastoma multiforme (GBM) challenges effective neuropathological treatment. The reliance on in vitro studies and…”
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The Immunological Epigenetic Landscape of the Human Life Trajectory by Juříčková, Iva, Hudec, Michael, Votava, Felix, Vosáhlo, Jan, Ovsepian, Saak Victor, Černá, Marie, O'Leary, Valerie Bríd

“…Adaptive immunity changes over an individual’s lifetime, maturing by adulthood and diminishing with old age. Epigenetic mechanisms involving DNA and histone…”
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All-Trans Retinoic Acid Fosters the Multifarious U87MG Cell Line as a Model of Glioblastoma by Pokorná, Markéta, Hudec, Michael, Juříčková, Iva, Vácha, Michael, Polívková, Zdeňka, Kútna, Viera, Pala, Jan, Ovsepian, Saak V., Černá, Marie, O’Leary, Valerie Bríd

“…Glioblastoma multiforme (GBM) is a primary brain cancer of poor prognosis, with existing treatments remaining essentially palliative. Current GBM therapy fails…”
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COMIRESTROKE—A clinical study protocol for monitoring clinical effect and molecular biological readouts of COMprehensive Intensive REhabilitation program after STROKE: A four-arm parallel-group randomized double blinded controlled trial with a longitudinal design by Řasová, Kamila, Martinková, Patrícia, Vařejková, Michaela, Miznerová, Barbora, Pavlíková, Markéta, Hlinovská, Jana, Hlinovský, David, Philippová, Štěpánka, Novotný, Michal, Pospíšilová, Karolína, Biedková, Paula, Vojíková, Romana, Havlík, Jan, O'Leary, Valerie Bríd, Černá, Marie, Bartoš, Aleš, Philipp, Tom

“…IntroductionWhile the role of physiotherapy as part of a comprehensive inpatient rehabilitation is indisputable, clear evidence concerning the effectiveness of…”
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Cerebellar demyelination and neurodegeneration associated with mTORC1 hyperactivity may contribute to the developmental onset of autism‐like neurobehavioral phenotype in a rat model by Kútna, Viera, O'Leary, Valerie Bríd, Hoschl, Cyril, Ovsepian, Saak V.

“…The cerebellum hosts more than half of all neurons of the human brain, with their organized activity playing a key role in coordinating motor functions…”
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The circRNA interactome-innovative hallmarks of the intra- and extracellular radiation response by O'Leary, Valerie Bríd, Smida, Jan, Matjanovski, Martina, Brockhaus, Corinna, Winkler, Klaudia, Moertl, Simone, Ovsepian, Saak Victor, Atkinson, Michael John

“…Generated by Quaking (QKI), circular RNAs (circRNAs) are newly recognised non-coding RNA (ncRNA) members characterised by tissue specificity, increased…”
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Celiac Disease Defined by Over-Sensitivity to Gliadin Activation and Superior Antigen Presentation of Dendritic Cells by Hudec, Michael, Riegerová, Kamila, Pala, Jan, Kútna, Viera, Černá, Marie, O´Leary, Valerie Bríd

“…The autoimmune condition, Celiac Disease (CeD), displays broad clinical symptoms due to gluten exposure. Its genetic association with DQ variants in the human…”
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The long non-coding RNA PARTICLE is associated with WWOX and the absence of FRA16D breakage in osteosarcoma patients by O'Leary, Valerie Bríd, Maugg, Doris, Smida, Jan, Baumhoer, Daniel, Nathrath, Michaela, Ovsepian, Saak Victor, Atkinson, Michael John

“…Breakage of the fragile site FRA16D disrupts the (WW Domain Containing Oxidoreductase) tumor suppressor gene in osteosarcoma. However, the frequency of…”
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