Search Results - "O’Leary, Michael E."

Single-cell analysis of sodium channel expression in dorsal root ganglion neurons by Ho, Cojen, O'Leary, Michael E.

“…Sensory neurons of the dorsal root ganglia (DRG) express multiple voltage-gated sodium (Na) channels that substantially differ in gating kinetics and…”
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Chronic exposure to tumor necrosis factor in vivo induces hyperalgesia, upregulates sodium channel gene expression and alters the cellular electrophysiology of dorsal root ganglion neurons by Fischer, Bradford D., Ho, Cojen, Kuzin, Igor, Bottaro, Andrea, O’Leary, Michael E.

“…•Hyperalgesia in tumor necrosis factor transgenic mice (TNFtg) was investigated.•Sodium (Na+) channel gene expression was upregulated in TNFtg sensory…”
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Modulation of Kv3.4 channel N‐type inactivation by protein kinase C shapes the action potential in dorsal root ganglion neurons by Ritter, David M., Ho, Cojen, O’Leary, Michael E., Covarrubias, Manuel

“…Non‐technical summary  The orchestrated activity of an ensemble of voltage‐gated ion channels determines the initiation, shape and duration of the action…”
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State-dependent trapping of flecainide in the cardiac sodium channel by Ramos, Eugene, O'Leary, Michael E.

“…Flecainide is a Class I antiarrhythmic drug and a potent inhibitor of the cardiac (Nav1.5) sodium channel. Although the flecainide inhibition of Nav1.5 is…”
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Regulatory Role of Voltage-Gated Na Channel β Subunits in Sensory Neurons by Chahine, Mohamed, O'Leary, Michael E

“…Voltage-gated sodium Na(+) channels are membrane-bound proteins incorporating aqueous conduction pores that are highly selective for sodium Na(+) ions. The…”
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MTSET modification of D4S6 cysteines stabilize the fast inactivated state of Nav1.5 sodium channels by O'Leary, Michael E, Chahine, Mohamed

“…The transmembrane S6 segments of Na(+) sodium channels form the cytoplasmic entrance of the channel and line the internal aspects of the aqueous pore. This…”
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Animal models of rheumatoid pain: experimental systems and insights by Fischer, Bradford D, Adeyemo, Adeshina, O'Leary, Michael E, Bottaro, Andrea

“…Severe chronic pain is one of the hallmarks and most debilitating manifestations of inflammatory arthritis. It represents a significant problem in the clinical…”
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Regulation of Nav1.6 and Nav1.8 peripheral nerve Na+ channels by auxiliary β-subunits by Zhao, Juan, O'Leary, Michael E, Chahine, Mohamed

“…Voltage-gated Na(+) (Na(v)) channels are composed of a pore-forming α-subunit and one or more auxiliary β-subunits. The present study investigated the…”
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Regulation/modulation of sensory neuron sodium channels by Chahine, Mohamed, O'Leary, Michael E

“…The pseudounipolar sensory neurons of the dorsal root ganglia (DRG) give rise to peripheral branches that convert thermal, mechanical, and chemical stimuli…”
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Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury by Ritter, David M, Zemel, Benjamin M, Hala, Tamara J, O'Leary, Michael E, Lepore, Angelo C, Covarrubias, Manuel

“…Spinal cord injury (SCI) patients develop chronic pain involving poorly understood central and peripheral mechanisms. Because dysregulation of the…”
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Role of voltage‐gated sodium, potassium and calcium channels in the development of cocaine‐associated cardiac arrhythmias by O'Leary, Michael E., Hancox, Jules C.

“…Cocaine is a highly active stimulant that alters dopamine metabolism in the central nervous system resulting in a feeling of euphoria that with time can lead…”
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Differential Expression of Sodium Channel β Subunits in Dorsal Root Ganglion Sensory Neurons by Ho, Cojen, Zhao, Juan, Malinowski, Steven, Chahine, Mohamed, O'Leary, Michael E.

“…The small-diameter (<25 μm) and large-diameter (>30 μm) sensory neurons of the dorsal root ganglion (DRG) express distinct combinations of tetrodotoxin…”
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Y1767C, a novel SCN5A mutation, induces a persistent Na+ current and potentiates ranolazine inhibition of Nav1.5 channels by Huang, Hai, Priori, Silvia G, Napolitano, Carlo, O'Leary, Michael E, Chahine, Mohamed

“…Long QT syndrome type 3 (LQT3) has been traced to mutations of the cardiac Na(+) channel (Na(v)1.5) that produce persistent Na(+) currents leading to delayed…”
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Gating Properties of Nav1.7 and Nav1.8 Peripheral Nerve Sodium Channels by Vijayaragavan, Kausalia, O'Leary, Michael E, Chahine, Mohamed

“…Several distinct components of voltage-gated sodium current have been recorded from native dorsal root ganglion (DRG) neurons that display differences in…”
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Inhibition of HERG potassium channels by cocaethylene: a metabolite of cocaine and ethanol by O'Leary, Michael E

“…To investigate the mechanism by which cocaethylene, a metabolite of cocaine and alcohol inhibits a cardiac delayed rectifier potassium channel. The cDNA of the…”
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Inhibition of human ether-a-go-go potassium channels by cocaine by O'Leary, M E

“…Cocaine is a potent cardiac stimulant and its use has been linked to life-threatening arrhythmias in humans. A prominent effect of cocaine in the heart is a…”
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Characterization of the isoform-specific differences in the gating of neuronal and muscle sodium channels by O'Leary, M E

“…Human heart (hH1), human skeletal muscle (hSkM1), and rat brain (rIIA) Na channels were expressed in cultured cells and the activation and inactivation of the…”
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Chronic Exposure to Tumor Necrosis Factor in Vivo Induces Hyperalgesia, Upregulates Sodium Channel Gene Expression and Alters the Cellular Electrophysiology of Dorsal Root Ganglion Neurons by O'Leary, Michael E., Bottaro, Andrea, Kuzin, Igor, Ho, Cojen, Fischer, Brad

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Regulation of Na v 1.6 and Na v 1.8 peripheral nerve Na + channels by auxiliary β-subunits by Zhao, Juan, O'Leary, Michael E., Chahine, Mohamed

“…Voltage-gated Na + (Na v ) channels are composed of a pore-forming α-subunit and one or more auxiliary β-subunits. The present study investigated the…”
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Regulatory role of voltage-gated sodium channel β subunits in sensory neurons by Mohamed eChahine, Michael E O'Leary

“…Voltage-gated Na+ channels are transmembrane-bound proteins incorporating aqueous conduction pores that are highly selective for Na+. The opening of these…”
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