Search Results - "O’Leary, Dennis D.M."

A transcription factor code defines nine sensory interneuron subtypes in the mechanosensory area of the spinal cord by Del Barrio, Marta Garcia, Bourane, Steeve, Grossmann, Katja, Schüle, Roland, Britsch, Stefan, O'Leary, Dennis D M, Goulding, Martyn

“…Interneurons in the dorsal spinal cord process and relay innocuous and nociceptive somatosensory information from cutaneous receptors that sense touch,…”
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Sensory cortex limits cortical maps and drives top-down plasticity in thalamocortical circuits by Zembrzycki, Andreas, Chou, Shen-Ju, Ashery-Padan, Ruth, Stoykova, Anastassia, O'Leary, Dennis D M

“…Primary somatosensory cortex (S1) contains a map of the body that mirrors maps in hindbrain and thalamus. During development, peripheral changes alter the map…”
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Lhx2 specifies regional fate in Emx1 lineage of telencephalic progenitors generating cerebral cortex by Chou, Shen-Ju, Kroll, Todd T, Perez-Garcia, Carlos G, O'Leary, Dennis D M

“…The authors show that the LIM homeodomain transcription factor Lhx2 is responsible for the fate decision of cortical progenitors to generate neocortex or…”
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Patterning centers, regulatory genes and extrinsic mechanisms controlling arealization of the neocortex by O'Leary, Dennis D.M, Nakagawa, Yasushi

“…The adult mammalian neocortex, the major region of the cerebral cortex, is divided into functionally specialized areas, defined by distinct architecture and…”
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EphB Forward Signaling Controls Directional Branch Extension and Arborization Required for Dorsal-Ventral Retinotopic Mapping by Hindges, Robert, McLaughlin, Todd, Genoud, Nicolas, Henkemeyer, Mark, O'Leary, Dennis D.M

“…We report that EphB receptors direct unique axonal behaviors required for mapping the dorsal-ventral (D-V) retinal axis along the lateral-medial (L-M) axis of…”
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Ephrin-A5 (AL-1/RAGS) Is Essential for Proper Retinal Axon Guidance and Topographic Mapping in the Mammalian Visual System by Frisén, Jonas, Yates, Paul A, McLaughlin, Todd, Friedman, Glenn C, O'Leary, Dennis D.M, Barbacid, Mariano

“…Ephrin-A5 (AL-1/RAGS), a ligand for Eph receptor tyrosine kinases, repels retinal axons in vitro and has a graded expression in the superior colliculus (SC),…”
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Extension of Long Leading Processes and Neuronal Migration in the Mammalian Brain Directed by the Chemoattractant Netrin-1 by Yee, Kathleen T, Simon, Horst H, Tessier-Lavigne, Marc, O'Leary, Dennis D.M

“…Long distance cell migration occurs throughout the developing CNS, but the underlying cellular and molecular mechanisms are poorly understood. We show that the…”
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APP binds DR6 to trigger axon pruning and neuron death via distinct caspases by O'Leary, Dennis D. M, Tessier-Lavigne, Marc, Nikolaev, Anatoly, McLaughlin, Todd

“…Naturally occurring axonal pruning and neuronal cell death help to sculpt neuronal connections during development, but their mechanistic basis remains poorly…”
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Topographically Specific Effects of ELF-1 on Retinal Axon Guidance In Vitro and Retinal Axon Mapping In Vivo by Nakamoto, Masaru, Cheng, Hwai-Jong, Friedman, Glenn C, McLaughlin, Todd, Hansen, Michael J, Yoon, Cliff H, O'Leary, Dennis D.M, Flanagan, John G

“…Topographic maps, which maintain the spatial order of neurons in the order of their axonal connections, are found throughout the nervous system. In the visual…”
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Axon retraction and degeneration in development and disease by LIQUN LUO, O'LEARY, Dennis D. M

“…The selective elimination of axons, dendrites, axon and dendrite branches, and synapses, without loss of the parent neurons, occurs during normal development…”
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Fgf10 Regulates Transition Period of Cortical Stem Cell Differentiation to Radial Glia Controlling Generation of Neurons and Basal Progenitors by Sahara, Setsuko, O'Leary, Dennis D.M.

“…Radial glia (RG), the progenitors of cortical neurons and basal progenitors (BPs), differentiate from neuroepithelial cells (NCs) with stem cell properties. We…”
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Molecular gradients and development of retinotopic maps by MCLAUGHLIN, Todd, O'LEARY, Dennis D. M

“…Gradients of axon guidance molecules have long been postulated to control the development of the organization of neural connections into topographic maps. We…”
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In Vivo Expression of a Light-Activatable Potassium Channel Using Unnatural Amino Acids by Kang, Ji-Yong, Kawaguchi, Daichi, Coin, Irene, Xiang, Zheng, O’Leary, Dennis D.M., Slesinger, Paul A., Wang, Lei

“…Optical control of protein function provides excellent spatial-temporal resolution for studying proteins in situ. Although light-sensitive exogenous proteins…”
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Role for Lhx2 in corticogenesis through regulation of progenitor differentiation by Chou, Shen-Ju, O'Leary, Dennis D.M.

“…The neocortex represents the brain region that has undergone a major increase in its relative size during the course of mammalian evolution. The larger cortex…”
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COUP-TFI regulates the balance of cortical patterning between frontal/motor and sensory areas by O'Leary, Dennis D M, Studer, Michèle, Armentano, Maria, Chou, Shen-Ju, Srubek Tomassy, Giulio, Leingärtner, Axel

“…We used cortex-specific deletion of the transcription factor gene COUP-TFI (also known as Nr2f1) in mice to demonstrate previously unknown fundamental roles…”
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Generation and analysis of an improved Foxg1-IRES-Cre driver mouse line by Kawaguchi, Daichi, Sahara, Setsuko, Zembrzycki, Andreas, O’Leary, Dennis D.M.

“…Foxg1 expression is highly restricted to the telencephalon and other head structures in the early embryo. This expression pattern has been exploited to…”
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EMX2 Regulates Sizes and Positioning of the Primary Sensory and Motor Areas in Neocortex by Direct Specification of Cortical Progenitors by Hamasaki, Tadashi, Leingärtner, Axel, Ringstedt, Thomas, O'Leary, Dennis D.M.

“…Genetic studies of neocortical area patterning are limited, because mice deficient for candidate regulatory genes die before areas emerge and have other…”
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Cloning and Cortical Expression of Rat Emx2 and Adenovirus-mediated Overexpression to Assess its Regulation of Area-specific Targeting of Thalamocortical Axons by Leingärtner, Axel, Richards, Linda J., Dyck, Richard H., Akazawa, Chihiro, O’Leary, Dennis D.M.

“…A goal of this study was to use recombinant adenovirus (AdV) to ectopically express Emx2 in the embryonic neocortex as a gain-of-function approach to study its…”
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Multiple EphB receptors mediate dorsal–ventral retinotopic mapping via similar bi-functional responses to ephrin-B1 by McLaughlin, Todd, Lim, Yoo-Shick, Santiago, Alicia, O'Leary, Dennis D.M.

“…The projection from the retina to the superior colliculus in mice is organized in a retinotopic map that develops through the formation and guidance of…”
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Formation of the Cortical Subventricular Zone Requires MDGA1-Mediated Aggregation of Basal Progenitors by Perez-Garcia, Carlos G., O’Leary, Dennis D.M.

“…The subventricular zone (SVZ) provides a specialized neurogenic microenvironment for proliferation and aggregation of basal progenitors (BPs). Our study…”
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