Search Results - "O’Keeffe, Martina B."

Purification and identification of dipeptidyl peptidase (DPP) IV inhibitory peptides from the macroalga Palmaria palmata by Harnedy, Pádraigín A., O’Keeffe, Martina B., FitzGerald, Richard J.

“…•Aqueous P. palmata protein extracts contain potent DPP-IV inhibitory peptides.•Novel peptide sequences were identified by UPLC–ESI-MS/MS.•These peptides were…”
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Bioactive peptides from Atlantic salmon (Salmo salar) with angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory, and antioxidant activities by Neves, Adriana C., Harnedy, Pádraigín A., O’Keeffe, Martina B., FitzGerald, Richard J.

“…•Protein extraction from salmon trimmings was optimized giving a yield of 93% (w/w).•Protein hydrolysates displayed good DPP-IV and ACE inhibitory, and…”
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Identification of short peptide sequences in complex milk protein hydrolysates by O’Keeffe, Martina B., FitzGerald, Richard J.

“…•UPLC–ESI q-TOF MS/MS has been applied for short peptide identification.•Di-, tri-, tetra- and penta peptides were efficiently fragmented.•Peptides were…”
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Fractionation and identification of Alaska pollock skin collagen-derived mineral chelating peptides by Guo, Lidong, Harnedy, Pádraigín A., O’Keeffe, Martina B., Zhang, Li, Li, Bafang, Hou, Hu, FitzGerald, Richard J.

“…•Ten new mineral chelating peptides were identified.•Cys, His, Asp and Glu residues are responsible for the metal chelating activity.•GPAGPHGPPG was identified…”
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Generation and identification of angiotensin converting enzyme (ACE) inhibitory peptides from a brewers’ spent grain protein isolate by Connolly, Alan, O’Keeffe, Martina B., Piggott, Charles O., Nongonierma, Alice B., FitzGerald, Richard J.

“…•BSG-PI hydrolysed with Alcalase resulted in an ACE IC50 of 0.32mgml−1.•RP-HPLC fractionated BSG-PI hydrolysates demonstrated increased ACE inhibition.•6…”
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Characterisation of the hydrolytic specificity of Aspergillus niger derived prolyl endoproteinase on bovine β-casein and determination of ACE inhibitory activity by Norris, Roseanne, Poyarkov, Alexey, O’Keeffe, Martina B., FitzGerald, Richard J.

“…•The hydrolytic specificity of prolyl endoproteinase (An-PEP) was assessed using β-casein.•Incubation of β-casein with An-PEP generated a highly potent ACE…”
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Identification of angiotensin converting enzyme inhibitory and antioxidant peptides in a whey protein concentrate hydrolysate produced at semi‐pilot scale by O'Keeffe, Martina B., Conesa, Celia, FitzGerald, Richard J.

“…Summary Antioxidant and angiotensin converting enzyme (ACE) inhibitory peptides were identified in a 5 kDa ultrafiltration permeate of a whey protein…”
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Fractionation and identification of antioxidant peptides from an enzymatically hydrolysed Palmaria palmata protein isolate by Harnedy, Pádraigín A., O'Keeffe, Martina B., FitzGerald, Richard J.

“…Proteins derived from the macroalgal species Palmaria palmata have emerged as potential substrates for the generation of bioactive peptides. The aim of this…”
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Peptide identification in a salmon gelatin hydrolysate with antihypertensive, dipeptidyl peptidase IV inhibitory and antioxidant activities by Neves, Adriana C., Harnedy, Pádraigín A., O'Keeffe, Martina B., Alashi, Monisola A., Aluko, Rotimi E., FitzGerald, Richard J.

“…Salmon gelatin (Salmo salar, SG) enzymatic hydrolysates were generated using Alcalase 2.4L, Alcalase 2.4L in combination with Flavourzyme 500L, Corolase PP,…”
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Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides by Harnedy, Pádraigín A., Parthsarathy, Vadivel, McLaughlin, Chris M., O'Keeffe, Martina B., Allsopp, Philip J., McSorley, Emeir M., O'Harte, Finbarr P.M., FitzGerald, Richard J.

“…Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to…”
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Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity by Harnedy-Rothwell, Pádraigín A., McLaughlin, Chris M., O'Keeffe, Martina B., Le Gouic, Aurélien V., Allsopp, Philip J., McSorley, Emeir M., Sharkey, Shaun, Whooley, Jason, McGovern, Brian, O'Harte, Finbarr P.M., FitzGerald, Richard J.

“…[Display omitted] •Boarfish muscle proteins contain peptides relevant to glycaemic management.•Novel peptide sequences were identified by UPLC-ESI-MS/MS.•These…”
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Extraction of antioxidant and ACE inhibitory peptides from Thai traditional fermented shrimp pastes by Kleekayai, Thanyaporn, Harnedy, Pádraigín A., O’Keeffe, Martina B., Poyarkov, Alexey A., CunhaNeves, Adriana, Suntornsuk, Worapot, FitzGerald, Richard J.

“…•Thai fermented shrimp pastes exhibited antioxidant and ACE inhibitory activity.•IEX and SPE were used to fractionate the peptides.•Novel antioxidant peptides…”
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Identification of bioactive peptides from brewers’ spent grain and contribution of Leu/Ile to bioactive potency by Cermeño, Maria, Connolly, Alan, O'Keeffe, Martina B., Flynn, Cal, Alashi, Adeola M., Aluko, Rotimi E., FitzGerald, Richard J.

“…[Display omitted] •A BSG hydrolysate had in vitro ORAC along with DPP-IV and ACE inhibitory activity.•The hydrolysate showed hypotensive effects in SHRs.•The…”
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Peptide identification from a Porphyra dioica protein hydrolysate with antioxidant, angiotensin converting enzyme and dipeptidyl peptidase IV inhibitory activities by Cermeño, Maria, Stack, Julianne, Tobin, Paul R, O'Keeffe, Martina B, Harnedy, Pádraigín A, Stengel, Dagmar B, FitzGerald, Richard J

“…A Porphyra dioica protein extract was enzymatically hydrolysed and then fractionated using semi-preparative reverse-phase high performance chromatography. The…”
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Peptide identification in a porcine gelatin prolyl endoproteinase hydrolysate with angiotensin converting enzyme (ACE) inhibitory and hypotensive activity by O'Keeffe, Martina B., Norris, Roseanne, Alashi, Monisola A., Aluko, Rotimi E., FitzGerald, Richard J.

“…•A potent ACE inhibitory gelatin An-PEP hydrolysate was generated.•The peptides within the hydrolysate were identified by UPLC-ESI-MS/MS.•Tri- and…”
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Isolation of peptides from a novel brewers spent grain protein isolate with potential to modulate glycaemic response by Connolly, Alan, O'Keeffe, Martina B., Nongonierma, Alice B., Piggott, Charles O., FitzGerald, Richard J.

“…Summary The in vitro dipeptidyl peptidase‐IV (DPP‐IV) inhibitory activity of a Brewers’ spent grain protein‐enriched isolate (BSG‐PI) Alcalase™ hydrolysate…”
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Antioxidant activity of bovine casein hydrolysates produced by Ficus carica L.-derived proteinase by Di Pierro, Giovanna, O’Keeffe, Martina B., Poyarkov, Alexey, Lomolino, Giovanna, FitzGerald, Richard J.

“…•Hydrolysis of bovine casein by Ficus carica latex proteinase preparation.•In vitro antioxidant activity determined by ORACFL assay.•Higher antioxidant…”
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Blue whiting (Micromesistius poutassou) muscle protein hydrolysate with in vitro and in vivo antidiabetic properties by Harnedy, Pádraigín A., Parthsarathy, Vadivel, McLaughlin, Chris M., O'Keeffe, Martina B., Allsopp, Philip J., McSorley, Emeir M., O'Harte, Finbarr P.M., FitzGerald, Richard J.

“…•A marine protein hydrolysate displayed antidiabetic activity in vitro and in vivo.•Insulin secretion was enhanced in cultured pancreatic BRIN-BD11…”
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Whey protein hydrolysate induced modulation of endothelial cell gene expression by O'Keeffe, Martina B., FitzGerald, Richard J.

“…•ACE inhibitory UF fractions of WPC hydrolysates were presented to HUVECs.•Microarray analysis showed differential expression of blood pressure control…”
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Agonist-dependent internalization and trafficking of the human prostacyclin receptor: A direct role for Rab5a GTPase by O'Keeffe, Martina B., Reid, Helen M., Kinsella, B. Therese

“…The human prostacyclin receptor (hIP) undergoes rapid agonist-induced internalization by largely unknown mechanism(s). Herein the involvement of Rab5 in…”
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