Search Results - "O’Keefe, Ryan"

HER2 expression identifies dynamic functional states within circulating breast cancer cells by Jordan, Nicole Vincent, Bardia, Aditya, Wittner, Ben S., Benes, Cyril, Ligorio, Matteo, Zheng, Yu, Yu, Min, Sundaresan, Tilak K., Licausi, Joseph A., Desai, Rushil, O’Keefe, Ryan M., Ebright, Richard Y., Boukhali, Myriam, Sil, Srinjoy, Onozato, Maristela L., Iafrate, Anthony J., Kapur, Ravi, Sgroi, Dennis, Ting, David T., Toner, Mehmet, Ramaswamy, Sridhar, Haas, Wilhelm, Maheswaran, Shyamala, Haber, Daniel A.

“…Patient-derived circulating tumour cells are used to characterize the dynamics and underlying plasticity of HER2 expression in non-HER2-amplified breast…”
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Effect of DNase I treatment and neutrophil depletion on acute limb ischemia-reperfusion injury in mice by Albadawi, Hassan, MD, Oklu, Rahmi, MD, PhD, Raacke Malley, Rita Elise, BS, O'Keefe, Ryan M., BS, Uong, Thuy P., BS Candidate, Cormier, Nicholas R., BS Candidate, Watkins, Michael T., MD

“…Objective Extracellular traps (ETs) consisting of DNA-protein complexes formed after tissue injury contribute to the inflammatory and thrombosis cascades,…”
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Analysis of Female Participant Representation in Registered Oncology Clinical Trials in the United States from 2008 to 2020 by Perera, Nirosha D, Bellomo, Tiffany R, Schmidt, Walker M, Litt, Henry K, Shyu, Margaret, Stavins, MaKenna A, Wang, Max M, Bell, Alexander, Saleki, Massoud, Wolf, Katherine I, Ionescu, Ruxandra, Tao, Jacqueline J, Ji, Sunjong, O’Keefe, Ryan M, Pun, Matthew, Takasugi, Jordan M, Steinberg, Jecca R, Go, Ronald S, Turner, Brandon E, Mahipal, Amit

“…Abstract Background Female underrepresentation in oncology clinical trials can result in outcome disparities. We evaluated female participant representation in…”
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Mechanisms of cellular crosstalk in the gastric tumor microenvironment are mediated by YAP1 and STAT3 by Thilakasiri, Pathum, O'Keefe, Ryan N, To, Sarah Q, Chisanga, David, Eissmann, Moritz F, Carli, Annalisa LE, Duscio, Belinda, Baloyan, David, Dmello, Rhynelle S, Williams, David, Mariadason, John, Poh, Ashleigh R, Pal, Bhupinder, Kile, Benjamin T, Vissers, Joseph Ha, Harvey, Kieran F, Buchert, Michael, Shi, Wei, Ernst, Matthias, Chand, Ashwini L

“…Deregulation of the Hippo pathway is a driver for cancer progression and treatment resistance. In the context of gastric cancer, YAP1 is a biomarker for poor…”
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Hind limb ischemia–reperfusion injury in diet-induced obese mice by Albadawi, Hassan, MD, Oklu, Rahmi, MD, PhD, Cormier, Nicholas R., BS, O'Keefe, Ryan M., BS, Heaton, James T., PhD, Kobler, James B., PhD, Austen, William G., MD, Watkins, Michael T., MD

“…Abstract Background Obesity is a major risk factor for the development of diabetes. Limb ischemia–reperfusion injury (IR) is a common clinical problem in…”
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Design and implementation of an Internet‐Based cancer risk assessment tool: Use over 10 years by LaRiviere, Michael J., O'Keefe, Ryan, Carpenter, Maribel, Chao, Hann‐Hsiang, Amaniera, Isabella, Vachani, Carolyn, Hampshire, Margaret K., Bach, Christina, Arnold‐Korzeniowski, Karen, Metz, James M., Hill‐Kayser, Christine

“…Background Prevention and early intervention can improve survival and quality of life across all cancers. Patient understanding of risk factors and associated…”
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Clusters of circulating tumor cells traverse capillary-sized vessels by Au, Sam H., Storey, Brian D., Moore, John C., Tang, Qin, Chen, Yeng-Long, Javaid, Sarah, Sarioglu, A. Fatih, Sullivan, Ryan, Madden, Marissa W., O’Keefe, Ryan, Haber, Daniel A., Maheswaran, Shyamala, Langenau, David M., Stott, Shannon L., Toner, Mehmet

“…Multicellular aggregates of circulating tumor cells (CTC clusters) are potent initiators of distant organ metastasis. However, it is currently assumed that CTC…”
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A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development by O’Keefe, Ryan N., Carli, Annalisa L. E., Baloyan, David, Chisanga, David, Shi, Wei, Afshar-Sterle, Shoukat, Eissmann, Moritz F., Poh, Ashleigh R., Pal, Bhupinder, Seillet, Cyril, Locksley, Richard M., Ernst, Matthias, Buchert, Michael

“…Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic…”
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Epicardial surgical ligation of the left atrial appendage is safe, reproducible, and effective by transesophageal echocardiographic follow-up by Zapolanski, Alex, Johnson, Christopher K, Dardashti, Omid, O'Keefe, Ryan M, Rioux, Nancy, Ferrari, Giovanni, Shaw, Richard E, Brizzio, Mariano E, Grau, Juan B

“…The left atrial appendage (LAA) is the source of 90% of thrombi in patients with atrial fibrillation. Our double LAA ligation (LLAA) technique was shown to be…”
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Crosstalk between epithelium, myeloid and innate lymphoid cells during gut homeostasis and disease by Ghilas, Sonia, O’Keefe, Ryan, Mielke, Lisa Anna, Raghu, Dinesh, Buchert, Michael, Ernst, Matthias

“…The gut epithelium not only provides a physical barrier to separate a noxious outside from a sterile inside but also allows for highly regulated interactions…”
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1857 Not the Average Pseudopolyp by Pathirana, Induruwa, O'Keefe, Ryan

“…INTRODUCTION: Polyposis syndromes are rare and often undiagnosed or misdiagnosed in clinical practice. Presented here is a case of Cowden syndrome initially…”
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1856 Immediate Air-Tight Seal With a Padlock Clip Defect Closure System for Iatrogenic Colonic Perforation by O'Keefe, Ryan, Pathirana, Induruwa

“…INTRODUCTION: Iatrogenic colonic perforations are an infrequent complication of endoscopy that often require immediate surgical repair. However, endoscopic…”
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Minimum 5-Year Follow-up Results: CROSSBAT (Combined Randomised and Observational Study of Surgery vs No Surgery for Type B Ankle Fracture Treatment) by O’Keefe, Ryan, Naylor, Justine M., Symes, Michael J., Harris, Ian A., Mittal, Rajat

“…Background: Isolated Weber B, AO (Association for the Study of Internal Fixation) type 44B ankle fractures with no fracture to the medial side are the most…”
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DCLK1 induces a pro-tumorigenic phenotype to drive gastric cancer progression by Afshar-Sterle, Shoukat, Carli, Annalisa L E, O'Keefe, Ryan, Tse, Janson, Fischer, Stefanie, Azimpour, Alexander I, Baloyan, David, Elias, Lena, Thilakasiri, Pathum, Patel, Onisha, Ferguson, Fleur M, Eissmann, Moritz F, Chand, Ashwini L, Gray, Nathanael S, Busuttil, Rita, Boussioutas, Alex, Lucet, Isabelle S, Ernst, Matthias, Buchert, Michael

“…Doublecortin-like kinase 1 (DCLK1) is a proposed driver of gastric cancer (GC) that phosphorylates serine and threonine residues. Here, we showed that the…”
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A Mouse Model for the Rapid and Binomial Assessment of Putative WNT/β-Catenin Signalling Inhibitors by Tse, Janson, O’Keefe, Ryan, Rigopolous, Angela, Carli, Annalisa L. E, Waaler, Jo, Krauss, Stefan, Ernst, Matthias, Buchert, Michael

“…Specific signalling thresholds of the WNT/β-catenin pathway affect embryogenesis and tissue homeostasis in the adult, with mutations in this pathway frequently…”
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Therapeutic inhibition of the SRC-kinase HCK facilitates T cell tumor infiltration and improves response to immunotherapy by Poh, Ashleigh R, Love, Christopher G, Chisanga, David, Steer, James H, Baloyan, David, Chopin, Michaël, Nutt, Stephen, Rautela, Jai, Huntington, Nicholas D, Etemadi, Nima, O'Brien, Megan, O'Keefe, Ryan, Ellies, Lesley G, Macri, Christophe, Mintern, Justine D, Whitehead, Lachlan, Gangadhara, Gangadhara, Boon, Louis, Chand, Ashwini L, Lowell, Clifford A, Shi, Wei, Pixley, Fiona J, Ernst, Matthias

“…Although immunotherapy has revolutionized cancer treatment, many immunogenic tumors remain refractory to treatment. This can be largely attributed to an…”
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An analysis of content of lay-press articles focused on cancer from leading U.S. newspapers from 2010 to 2019 by Adwetewa-Badu, Abena A., O'Keefe, Ryan M, Callahan, Joseph X., Taylor, Catherine A., Gjino, Chris P., Hill-Kayser, Christine E.

“…Abstract only e24032 Background: Newspaper coverage of cancer-related topics has historically focused on research, treatment, survival, and impact of tobacco…”
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Abstract PS7-80: Family history (FH) of breast cancer (BC) and associated risk-factors and screening: Analysis of an internet-based risk assessment tool by O'Keefe, Ryan, LaRiviere, Michael, Vachani, Carolyn, Hampshire, Margaret, Bach, Christina, Arnold-Korzeniowski, Karen, Healy, Marisa, Metz, James, Hill-Kayser, Christine

“…Abstract BackgroundBreast cancer (BC) is the most common cancer in women worldwide, and a leading cause of death. There are well established risk-factors for…”
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Multicenter experience with extraction of the Riata/Riata ST ICD lead by Maytin, Melanie, MD, MSc, FHRS, Wilkoff, Bruce L., MD, FHRS, Brunner, Michael, MD, Cronin, Edmond, MD, Love, Charles J., MD, FHRS, Grazia Bongiorni, Maria, MD, Segreti, Luca, MD, Carrillo, Roger G., MD, FHRS, Garisto, Juan D., MD, Kutalek, Steven, MD, FHRS, Subzposh, Faiz, MD, Fischer, Avi, MD, Coffey, James O., MD, Gangireddy, Sandeep R., MD, Saba, Samir, MD, FHRS, Mittal, Suneet, MD, FHRS, Arshad, Aysha, MD, FHRS, O’Keefe, Ryan Michael, MD, Henrikson, Charles A., MD, FHRS, Belott, Peter, MD, FHRS, John, Roy M., MD, PhD, FHRS, Epstein, Laurence M., MD

“…Background In November 2011, the Food and Drug Administration issued a class I recall of Riata and Riata ST implantable cardioverter-defibrillator leads…”
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An analysis of characteristics and content of highly used books for the general population in the cancer space on Amazon.com by O'Keefe, Ryan M, Keaveny, Caitlin E., Vesey, Alicia M., Jordan, Mackenzie R., Hamilton, Grace A., Letendre, Nicole B., Santiago, Simonai E., Hill-Kayser, Christine E.

“…Abstract only e24034 Background: Cancer patients and supporters frequently turn to written resources for assistance and empowerment in decision-making…”
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