Search Results - "O’Harte, Finbarr P. M."

Long-term treatment with acylated analogues of apelin-13 amide ameliorates diabetes and improves lipid profile of high-fat fed mice by O'Harte, Finbarr P M, Parthsarathy, Vadivel, Hogg, Christopher, Flatt, Peter R

“…Previous studies have shown that modified apelin analogues exhibited enzyme resistance in plasma and improved circulating half-life compared to apelin-13. This…”
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A novel DPP IV-resistant C-terminally extended glucagon analogue exhibits weight-lowering and diabetes-protective effects in high-fat-fed mice mediated through glucagon and GLP-1 receptor activation by Lynch, Aisling M., Pathak, Nupur, Pathak, Varun, O’Harte, Finbarr P. M., Flatt, Peter R., Irwin, Nigel, Gault, Victor A.

“…Aims/hypothesis Modification of the structure of glucagon could provide useful compounds for the potential treatment of obesity-related diabetes. Methods This…”
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Potential Therapeutic Role for Apelin and Related Peptides in Diabetes: An Update by Palmer, Ethan S, Irwin, Nigel, O’Harte, Finbarr PM

“…Type 2 diabetes mellitus (T2DM) is an epidemic with an ever-increasing global prevalence. Current treatment strategies, although plentiful and somewhat…”
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Sustained glucagon receptor antagonism in insulin-deficient high-fat-fed mice by Lafferty, Ryan A, McShane, Laura M, Franklin, Zara J, Flatt, Peter R, O’Harte, Finbarr P M, Irwin, Nigel

“…Discerning modification to the amino acid sequence of native glucagon can generate specific glucagon receptor (GCGR) antagonists, that include…”
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Exendin-4 stimulates autophagy in pancreatic β-cells via the RAPGEF/EPAC-Ca2+-PPP3/calcineurin-TFEB axis by Zummo, Francesco P, Krishnanda, Stanislaus I, Georgiou, Merilin, O'Harte, Finbarr PM, Parthsarathy, Vadivel, Cullen, Kirsty S, Honkanen-Scott, Minna, Shaw, James AM, Lovat, Penny E, Arden, Catherine

“…Macroautophagy/autophagy is critical for the regulation of pancreatic β-cell mass and its deregulation has been implicated in the pathogenesis of type 2…”
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Insulinotropic actions of nateglinide in type 2 diabetic patients and effects on dipeptidyl peptidase-IV activity and glucose-dependent insulinotropic polypeptide degradation by McKillop, Aine M, Duffy, Nicola A, Lindsay, John R, Green, Brian D, Patterson, S, O'Harte, Finbarr P M, Bell, Patrick M, Flatt, Peter R

“…BackgroundNateglinide restores early-phase insulin secretion to feeding and reduces postprandial hyperglycaemia in type 2 diabetes. This study evaluated the…”
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Proglucagon-Derived Peptides as Therapeutics by Lafferty, Ryan A, O'Harte, Finbarr P M, Irwin, Nigel, Gault, Victor A, Flatt, Peter R

“…Initially discovered as an impurity in insulin preparations, our understanding of the hyperglycaemic hormone glucagon has evolved markedly over subsequent…”
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Physicochemical, Nutritional and In Vitro Antidiabetic Characterisation of Blue Whiting ( Micromesistius poutassou ) Protein Hydrolysates by Harnedy-Rothwell, Pádraigín A, Khatib, Neda, Sharkey, Shaun, Lafferty, Ryan A, Gite, Snehal, Whooley, Jason, O'Harte, Finbarr Pm, FitzGerald, Richard J

“…Protein hydrolysates from low-value underutilised fish species are potential sources of high-quality dietary protein and health enhancing peptides. Six blue…”
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Development of novel ligands for peptide GPCRs by Moran, Brian M, McKillop, Aine M, O’Harte, Finbarr PM

“…Graphical abstract…”
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Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1 by Green, Brian D., Irwin, Nigel, Duffy, Nicola A., Gault, Victor A., O'Harte, Finbarr P.M., Flatt, Peter R.

“…GLP-1 and GIP are insulin-releasing ‘incretin’ hormones inactivated following degradation by dipeptidyl peptidase IV. Incretin hormone analogues resistant to…”
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Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein by Cullen, Kirsty S., Al-Oanzi, Ziad H., O'Harte, Finbarr P.M., Agius, Loranne, Arden, Catherine

“…Glucokinase activity is a major determinant of hepatic glucose metabolism and blood glucose homeostasis. Liver glucokinase activity is regulated acutely by…”
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Fatty acid derivatised analogues of glucose-dependent insulinotropic polypeptide with improved antihyperglycaemic and insulinotropic properties by Kerr, Barry D., Irwin, Nigel, O’Harte, Finbarr P.M., Bailey, Clifford J., Flatt, Peter R., Gault, Victor A.

“…C-terminal acylation of Lys 37 with myristic (MYR; tetradecanoic acid), palmitic (PAL; hexadecanoic acid) and stearic (octadecanoic acid) fatty acids with or…”
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Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: Nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1 by Duffy, Nicola A., Green, Brian D., Irwin, Nigel, Gault, Victor A., McKillop, Aine M., O'Harte, Finbarr P.M., Flatt, Peter R.

“…Dipeptidyl peptidase IV (DPP IV) is the primary inactivator of glucoregulatory incretin hormones. This has lead to development of DPP IV inhibitors as a new…”
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Atlantic salmon (Salmo salar) co-product-derived protein hydrolysates: A source of antidiabetic peptides by Harnedy, Pádraigín A., Parthsarathy, Vadivel, McLaughlin, Chris M., O'Keeffe, Martina B., Allsopp, Philip J., McSorley, Emeir M., O'Harte, Finbarr P.M., FitzGerald, Richard J.

“…Large quantities of low-value protein rich co-products, such as salmon skin and trimmings, are generated annually. These co-products can be upgraded to…”
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Beneficial actions of a long‐acting apelin analogue in diabetes are related to positive effects on islet cell turnover and transdifferentiation by Tanday, Neil, Irwin, Nigel, Moffett, R. Charlotte, Flatt, Peter R., O'Harte, Finbarr P. M.

“…Aim The current study has tested the hypothesis that the positive effects of apelin receptor activation in diabetes are linked to benefits on islet cell…”
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Identification and characterisation of peptides from a boarfish (Capros aper) protein hydrolysate displaying in vitro dipeptidyl peptidase-IV (DPP-IV) inhibitory and insulinotropic activity by Harnedy-Rothwell, Pádraigín A., McLaughlin, Chris M., O'Keeffe, Martina B., Le Gouic, Aurélien V., Allsopp, Philip J., McSorley, Emeir M., Sharkey, Shaun, Whooley, Jason, McGovern, Brian, O'Harte, Finbarr P.M., FitzGerald, Richard J.

“…[Display omitted] •Boarfish muscle proteins contain peptides relevant to glycaemic management.•Novel peptide sequences were identified by UPLC-ESI-MS/MS.•These…”
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The bioactive conformation of glucose-dependent insulinotropic polypeptide by NMR and CD spectroscopy by Alaña, Iñigo, Malthouse, J. Paul G., O'Harte, Finbarr P. M., Hewage, Chandralal M.

“…Glucose‐dependent insulinotropic polypeptide (GIP) is a gastrointestinal incretin hormone, which modulates physiological insulin secretion. Because of its…”
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An update on galanin and spexin and their potential for the treatment of type 2 diabetes and related metabolic disorders by Gallagher, Daniel M, O'Harte, Finbarr P M, Irwin, Nigel

“…Spexin (SPX) and galanin (GAL) are two neuropeptides widely expressed in the central nervous system as well as within peripheral tissues in humans and other…”
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Chronic apelin analogue administration is more effective than established incretin therapies for alleviating metabolic dysfunction in diabetic db/db mice by O'Harte, Finbarr P.M., Parthsarathy, Vadivel, Flatt, Peter R.

“…Stable apelin-13 peptide analogues have shown promising acute antidiabetic effects in mice with diet-induced obesity diabetes. Here the efficacy of…”
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Dual-agonist incretin peptides from fish with potential for obesity-related Type 2 diabetes therapy – A review by Conlon, J. Michael, O’Harte, Finbarr P.M., Flatt, Peter R.

“…•Proglucagon-derived peptide from phylogenetically ancient fish are dual-agonists at GLP1R and GCGR.•Paddlefish glucagon and lamprey GLP-1 are the most potent…”
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