Search Results - "O’Hara, Darren M."

LRRK2 and α-Synuclein: Distinct or Synergistic Players in Parkinson’s Disease? by O’Hara, Darren M., Pawar, Grishma, Kalia, Suneil K., Kalia, Lorraine V.

“…Parkinson’s disease (PD) is the most common neurodegenerative movement disorder, characterized by prominent degeneration of dopaminergic neurons in the…”
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Methods for detecting toxic α-synuclein species as a biomarker for Parkinson's disease by O'Hara, Darren M., Kalia, Suneil K., Kalia, Lorraine V.

“…Parkinson's disease (PD) is the most common neurodegenerative movement disorder and is characterized by the accumulation of α-synuclein (α-syn) into insoluble…”
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Bcl-2-associated athanogene 5 (BAG5) regulates Parkin-dependent mitophagy and cell death by De Snoo, Mitchell L., Friesen, Erik L., Zhang, Yu Tong, Earnshaw, Rebecca, Dorval, Geneviève, Kapadia, Minesh, O’Hara, Darren M., Agapova, Victoria, Chau, Hien, Pellerito, Ornella, Tang, Matthew Y., Wang, Xinzhu, Schmitt-Ulms, Gerold, Durcan, Thomas M., Fon, Edward A., Kalia, Lorraine V., Kalia, Suneil K.

“…As pathogenic Parkin mutations result in the defective clearance of damaged mitochondria, Parkin-dependent mitophagy is thought to be protective against the…”
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Semi-Quantitative Determination of Dopaminergic Neuron Density in the Substantia Nigra of Rodent Models using Automated Image Analysis by O'Hara, Darren M, Kapadia, Minesh, Ping, Susan, Kalia, Suneil K, Kalia, Lorraine V

“…Estimation of the number of dopaminergic neurons in the substantia nigra is a key method in pre-clinical Parkinson's disease research. Currently, unbiased…”
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Disrupting the α-synuclein-ESCRT interaction with a peptide inhibitor mitigates neurodegeneration in preclinical models of Parkinson’s disease by Nim, Satra, O’Hara, Darren M., Corbi-Verge, Carles, Perez-Riba, Albert, Fujisawa, Kazuko, Kapadia, Minesh, Chau, Hien, Albanese, Federica, Pawar, Grishma, De Snoo, Mitchell L., Ngana, Sophie G., Kim, Jisun, El-Agnaf, Omar M. A., Rennella, Enrico, Kay, Lewis E., Kalia, Suneil K., Kalia, Lorraine V., Kim, Philip M.

“…Accumulation of α-synuclein into toxic oligomers or fibrils is implicated in dopaminergic neurodegeneration in Parkinson’s disease. Here we performed a…”
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Emerging disease‐modifying strategies targeting α‐synuclein for the treatment of Parkinson's disease by O'Hara, Darren M, Kalia, Suneil K, Kalia, Lorraine V

“…Parkinson's disease is the most common neurodegenerative movement disorder. It arises as a result of neuronal cell death in specific brain regions, notably the…”
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Metabolic Labeling of Primary Neurons Using Carbohydrate Click Chemistry by Hayes, Jerrard M, O'Hara, Darren M, Davey, Gavin P

“…Glycans play an important role in many neuronal processes, such as neurotransmitter release and reuptake, cell-cell communication and adhesion, modulation of…”
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Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by α-synuclein by McKinnon, Chris, De Snoo, Mitchell L, Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G, O'Hara, Darren M, Brotchie, Jonathan M, Koprich, James B, Lozano, Andres M, Kalia, Lorraine V, Kalia, Suneil K

“…Parkinson's disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded α-synuclein in selected brain regions, including…”
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Small molecule inhibitors of α-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans by Chen, Kevin S, Menezes, Krystal, Rodgers, Jarlath B, O'Hara, Darren M, Tran, Nhat, Fujisawa, Kazuko, Ishikura, Seiya, Khodaei, Shahin, Chau, Hien, Cranston, Anna, Kapadia, Minesh, Pawar, Grishma, Ping, Susan, Krizus, Aldis, Lacoste, Alix, Spangler, Scott, Visanji, Naomi P, Marras, Connie, Majbour, Nour K, El-Agnaf, Omar M A, Lozano, Andres M, Culotti, Joseph, Suo, Satoshi, Ryu, William S, Kalia, Suneil K, Kalia, Lorraine V

“…Parkinson's disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by α-synuclein oligomers. There is an…”
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BAG5 Promotes Alpha-Synuclein Oligomer Formation and Functionally Interacts With the Autophagy Adaptor Protein p62 by Friesen, Erik L., Zhang, Yu Tong, Earnshaw, Rebecca, De Snoo, Mitch L., O’Hara, Darren M., Agapova, Victoria, Chau, Hien, Ngana, Sophie, Chen, Kevin S., Kalia, Lorraine V., Kalia, Suneil K.

“…Molecular chaperones are critical to maintaining intracellular proteostasis and have been shown to have a protective role against alpha-synuclein-mediated…”
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Small molecule inhibitors of [alpha]-synuclein oligomers identified by targeting early dopamine-mediated motor impairment in C. elegans by Chen, Kevin S, Menezes, Krystal, Rodgers, Jarlath B, O'Hara, Darren M, Tran, Nhat, Fujisawa, Kazuko, Ishikura, Seiya, Khodaei, Shahin, Chau, Hien, Cranston, Anna, Kapadia, Minesh, Pawar, Grishma, Ping, Susan, Krizus, Aldis, Lacoste, Alix, Spangler, Scott, Visanji, Naomi P, Marras, Connie, Majbour, Nour K, El-Agnaf, Omar M. A, Lozano, Andres M, Culotti, Joseph, Suo, Satoshi, Ryu, William S, Kalia, Suneil K, Kalia, Lorraine V

“…Background Parkinson's disease is a disabling neurodegenerative movement disorder characterized by dopaminergic neuron loss induced by [alpha]-synuclein…”
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Early-onset impairment of the ubiquitin-proteasome system in dopaminergic neurons caused by [alpha]-synuclein by McKinnon, Chris, De Snoo, Mitchell L, Gondard, Elise, Neudorfer, Clemens, Chau, Hien, Ngana, Sophie G, O'Hara, Darren M, Brotchie, Jonathan M, Koprich, James B, Lozano, Andres M, Kalia, Lorraine V, Kalia, Suneil K

“…Parkinson's disease is a progressive neurodegenerative disorder characterised by the accumulation of misfolded [alpha]-synuclein in selected brain regions,…”
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