Search Results - "O’Grady, Brian"

Biofunctionalized gelatin hydrogels support development and maturation of iPSC-derived cortical organoids by Kjar, Andrew, Haschert, Mia R., Zepeda, José C., Simmons, A. Joey, Yates, Alexis, Chavarria, Daniel, Fernandez, Melanie, Robertson, Gabriella, Abdulrahman, Adam M., Kim, Hyosung, Marguerite, Nicole T., Moen, Rachel K., Drake, Lauren E., Curry, Corinne W., O’Grady, Brian J., Gama, Vivian, Lau, Ken S., Grueter, Brad, Brunger, Jonathan M., Lippmann, Ethan S.

“…Human neural organoid models have become an important tool for studying neurobiology. However, improving the representativeness of neural cell populations in…”
Get full text

Development of an N‑Cadherin Biofunctionalized Hydrogel to Support the Formation of Synaptically Connected Neural Networks by O’Grady, Brian J, Balotin, Kylie M, Bosworth, Allison M, McClatchey, P. Mason, Weinstein, Robert M, Gupta, Mukesh, Poole, Kara S, Bellan, Leon M, Lippmann, Ethan S

“…In vitro models of the human central nervous system (CNS), particularly those derived from induced pluripotent stem cells (iPSCs), are becoming increasingly…”
Get full text

Growth factor free, peptide-functionalized gelatin hydrogel promotes arteriogenesis and attenuates tissue damage in a murine model of critical limb ischemia by Curry, Corinne W, Sturgeon, Sarah M, O'Grady, Brian J, Yates, Alexis, Kjar, Andrew, Paige, Hayden, Mowery, Lucas S, Katdare, Ketaki A, Patel, Riya, Mlouk, Kate, Stiefbold, Madison R, Vafaie-Partin, Sidney, Kawabata, Atsuyuki, McKee, Rachel, Moore-Lotridge, Stephanie, Hawkes, Adrienne, Kusunose, Jiro, Gibson-Corley, Katherine N, Schmeckpeper, Jeffrey, Schoenecker, Jonathan G, Caskey, Charles F, Lippmann, Ethan S

“…Critical limb ischemia (CLI) occurs when blood flow is restricted through the arteries, resulting in ulcers, necrosis, and chronic wounds in the downstream…”
Get full text

Rapid prototyping of cell culture microdevices using parylene-coated 3D prints by O'Grady, Brian J, Geuy, Michael D, Kim, Hyosung, Balotin, Kylie M, Allchin, Everett R, Florian, David C, Bute, Neelansh N, Scott, Taylor E, Lowen, Gregory B, Fricker, Colin M, Fitzgerald, Matthew L, Guelcher, Scott A, Wikswo, John P, Bellan, Leon M, Lippmann, Ethan S

“…Fabrication of microfluidic devices by photolithography generally requires specialized training and access to a cleanroom. As an alternative, 3D printing…”
Get more information

Spin∞: an updated miniaturized spinning bioreactor design for the generation of human cerebral organoids from pluripotent stem cells by Romero-Morales, Alejandra I., O'Grady, Brian J., Balotin, Kylie M., Bellan, Leon M., Lippmann, Ethan S., Gama, Vivian

“…[Display omitted] Three-dimensional (3D) brain organoids derived from human pluripotent stem cells (hPSCs), including human embryonic stem cells (hESCs) and…”
Get full text

Spatiotemporal Control of Morphogen Delivery to Pattern Stem Cell Differentiation in Three-Dimensional Hydrogels by O'Grady, Brian J, Balikov, Daniel A, Lippmann, Ethan S, Bellan, Leon M

“…Morphogens are biological molecules that alter cellular identity and behavior across both space and time. During embryonic development, morphogen spatial…”
Get more information

Pretreatment Spatially Aware Magnetic Resonance Imaging Radiomics Can Predict Distant Brain Metastases (DBMs) After Stereotactic Radiosurgery/Radiation Therapy (SRS/SRT) by Bae, Joseph, Mani, Kartik, Zabrocka, Ewa, Cattell, Renee, O'Grady, Brian, Payne, David, Roberson, John, Ryu, Samuel, Prasanna, Prateek

“…Stereotactic radiosurgery/radiation therapy (SRS/SRT) increasingly has been used to treat brain metastases. However, the development of distant brain…”
Get full text

Hepatitis C virus seroprevalence and prevalence of chronic infection in the adult population in Ireland: a study of residual sera, April 2014 to February 2016 by Garvey, Patricia, O'Grady, Brian, Franzoni, Geraldine, Bolger, Maeve, Irwin Crosby, Katie, Connell, Jeff, Burke, Deirdre, De Gascun, Cillian, Thornton, Lelia

“…Robust data on hepatitis C virus (HCV) population prevalence are essential to inform national HCV services. In 2016, we undertook a survey to estimate HCV…”
Get full text

A Customizable, Low-Cost Perfusion System for Sustaining Tissue Constructs by O'Grady, Brian J, Wang, Jason X, Faley, Shannon L, Balikov, Daniel A, Lippmann, Ethan S, Bellan, Leon M

“…The fabrication of engineered vascularized tissues and organs requiring sustained, controlled perfusion has been facilitated by the development of several pump…”
Get more information

Spatiotemporal control and modeling of morphogen delivery to induce gradient patterning of stem cell differentiation using fluidic channels by O'Grady, Brian, Balikov, Daniel A, Wang, Jason X, Neal, Emma K, Ou, Yu-Chuan, Bardhan, Rizia, Lippmann, Ethan S, Bellan, Leon M

“…The process of cell differentiation in a developing embryo is influenced by numerous factors, including various biological molecules whose presentation varies…”
Get more information

Influence of Substrate Stiffness on Barrier Function in an iPSC-Derived In Vitro Blood-Brain Barrier Model by Bosworth, Allison M., Kim, Hyosung, O’Grady, Kristin P., Richter, Isabella, Lee, Lynn, O’Grady, Brian J., Lippmann, Ethan S.

“…Introduction Vascular endothelial cells respond to a variety of biophysical cues such as shear stress and substrate stiffness. In peripheral vasculature,…”
Get full text

Intracellular acidosis and pH regulation in central respiratory chemoreceptors by Ravindran, C R Marutha, Bayne, James N, Bravo, Sara C, Busby, Theo, Crain, Charles N, Escobedo, John A, Gresham, Kenneth, O'Grady, Brian J, Rios, Lourdes, Roy, Shashwata, Gdovin, Matthew J

“…Dysfunctions of brainstem regions responsible for central CO2 chemoreception have been proposed as an underlying pathophysiology of Sudden Infant Death…”
Get more information

Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3 by Campbell, Nicholas G., Shekar, Aparna, Aguilar, Jenny I., Peng, Dungeng, Navratna, Vikas, Yang, Dongxue, Morley, Alexander N., Duran, Amanda M., Galli, Greta, O’Grady, Brian, Ramachandran, Ramnarayan, Sutcliffe, James S., Sitte, Harald H., Erreger, Kevin, Meiler, Jens, Stockner, Thomas, Bellan, Leon M., Matthies, Heinrich J. G., Gouaux, Eric, Mchaourab, Hassane S., Galli, Aurelio

“…The human dopamine (DA) transporter (hDAT) mediates clearance of DA. Genetic variants in hDAT have been associated with DA dysfunction, a complication…”
Get full text

Anxiety, panic and adult asthma: A cognitive-behavioral perspective by Deshmukh, Vandana M, Toelle, Brett G, Usherwood, Tim, O’Grady, Brian, Jenkins, Christine R

“…Summary A review of previous research suggests increased probability of the prevalence of anxiety disorders, and particularly panic disorder and panic attacks…”
Get full text

Design, Development, and Modeling of Perfusable Hydrogels to Regulate Cell Fate and Behavior in 3D Constructs by O'Grady, Brian

“…Despite numerous promising preclinical in vivo models and several decades of clinical trials, the overwhelming majority of human drug trials have failed to…”
Get full text

A novel drug therapeutic treatment: Hydrogen uncaging using flash photolysis for fast and focal intracellular acidification as a cancer therapeutic system by O'Grady, Brian

“…Current therapies for many types of cancers involve the disruption of the cancer cells' ability to alter intracellular pH (pH i). Virtually all mammalian…”
Get full text

The association of comorbid anxiety and depression with asthma-related quality of life and symptom perception in adults by DESHMUKH, Vandana M., TOELLE, Brett G., USHERWOOD, Tim, O'GRADY, Brian, JENKINS, Christine R.

“…Background and objective:  There are limited data on the association and interaction between anxiety and depression comorbidity and asthma‐related quality of…”
Get full text

Drywell Replica by O'Grady, Brian

“…"I am definitely happy with the results," said [ChrisPelchat]. "The vendors on the project were all new to nuclear prior to this. The drywell mockup gave them…”
Get full text

Continued Focus on Excellence by O'Grady, Brian

“…[Guy Cooper] purchased the old Surry unit 1 Westinghouse main generator stator in May 2006, put the 1.2 million pound component on a barge in Virginia, and…”
Get full text

Run, Novak, run by O'Grady, Brian

Get full text