Search Results - "O’Donovan, M. C."

Evaluating historical candidate genes for schizophrenia by Farrell, M S, Werge, T, Sklar, P, Owen, M J, Ophoff, R A, O'Donovan, M C, Corvin, A, Cichon, S, Sullivan, P F

“…Prior to the genome-wide association era, candidate gene studies were a major approach in schizophrenia genetics. In this invited review, we consider the…”
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The genetics of schizophrenia and bipolar disorder: dissecting psychosis by Craddock, N, O’Donovan, M C, Owen, M J

“…Much work has been done to identify susceptibility genes in schizophrenia and bipolar disorder. Several well established linkages have emerged in…”
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Convergent functional genomics of schizophrenia: from comprehensive understanding to genetic risk prediction by Ayalew, M, Le-Niculescu, H, Levey, D F, Jain, N, Changala, B, Patel, S D, Winiger, E, Breier, A, Shekhar, A, Amdur, R, Koller, D, Nurnberger, J I, Corvin, A, Geyer, M, Tsuang, M T, Salomon, D, Schork, N J, Fanous, A H, O'Donovan, M C, Niculescu, A B

“…We have used a translational convergent functional genomics (CFG) approach to identify and prioritize genes involved in schizophrenia, by gene-level…”
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Copy number variation in schizophrenia in Sweden by Szatkiewicz, J P, O'Dushlaine, C, Chen, G, Chambert, K, Moran, J L, Neale, B M, Fromer, M, Ruderfer, D, Akterin, S, Bergen, S E, Kähler, A, Magnusson, P K E, Kim, Y, Crowley, J J, Rees, E, Kirov, G, O'Donovan, M C, Owen, M J, Walters, J, Scolnick, E, Sklar, P, Purcell, S, Hultman, C M, McCarroll, S A, Sullivan, P F

“…Schizophrenia (SCZ) is a highly heritable neuropsychiatric disorder of complex genetic etiology. Previous genome-wide surveys have revealed a greater burden of…”
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Psychosis Genetics: Modeling the Relationship Between Schizophrenia, Bipolar Disorder, and Mixed (or "Schizoaffective") Psychoses by Craddock, Nick, O'Donovan, M. C., Owen, M. J.

“…As a result of improving technologies and greatly increased sample sizes, the last 2 years has seen unprecedented advances in identification of specific…”
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Genome-wide significant associations in schizophrenia to ITIH3/4, CACNA1C and SDCCAG8, and extensive replication of associations reported by the Schizophrenia PGC by Hamshere, M L, Walters, J T R, Smith, R, Richards, A L, Green, E, Grozeva, D, Jones, I, Forty, L, Jones, L, Gordon-Smith, K, Riley, B, O'Neill, T, Kendler, K S, Sklar, P, Purcell, S, Kranz, J, Morris, D, Gill, M, Holmans, P, Craddock, N, Corvin, A, Owen, M J, O'Donovan, M C

“…The Schizophrenia Psychiatric Genome-Wide Association Study Consortium (PGC) highlighted 81 single-nucleotide polymorphisms (SNPs) with moderate evidence for…”
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De novo CNV analysis implicates specific abnormalities of postsynaptic signalling complexes in the pathogenesis of schizophrenia by Kirov, G, Pocklington, A J, Holmans, P, Ivanov, D, Ikeda, M, Ruderfer, D, Moran, J, Chambert, K, Toncheva, D, Georgieva, L, Grozeva, D, Fjodorova, M, Wollerton, R, Rees, E, Nikolov, I, van de Lagemaat, L N, Bayés, À, Fernandez, E, Olason, P I, Böttcher, Y, Komiyama, N H, Collins, M O, Choudhary, J, Stefansson, K, Stefansson, H, Grant, S G N, Purcell, S, Sklar, P, O'Donovan, M C, Owen, M J

“…A small number of rare, recurrent genomic copy number variants (CNVs) are known to substantially increase susceptibility to schizophrenia. As a consequence of…”
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Functional gene group analysis identifies synaptic gene groups as risk factor for schizophrenia by Lips, E S, Cornelisse, L N, Toonen, R F, Min, J L, Hultman, C M, Holmans, P A, O'Donovan, M C, Purcell, S M, Smit, A B, Verhage, M, Sullivan, P F, Visscher, P M, Posthuma, D

“…Schizophrenia is a highly heritable disorder with a polygenic pattern of inheritance and a population prevalence of ∼1%. Previous studies have implicated…”
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Genome-wide analysis of over 106 000 individuals identifies 9 neuroticism-associated loci by Smith, D J, Escott-Price, V, Davies, G, Bailey, M E S, Colodro-Conde, L, Ward, J, Vedernikov, A, Marioni, R, Cullen, B, Lyall, D, Hagenaars, S P, Liewald, D C M, Luciano, M, Gale, C R, Ritchie, S J, Hayward, C, Nicholl, B, Bulik-Sullivan, B, Adams, M, Couvy-Duchesne, B, Graham, N, Mackay, D, Evans, J, Smith, B H, Porteous, D J, Medland, S E, Martin, N G, Holmans, P, McIntosh, A M, Pell, J P, Deary, I J, O'Donovan, M C

“…Neuroticism is a personality trait of fundamental importance for psychological well-being and public health. It is strongly associated with major depressive…”
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The catechol-O-methyl transferase (COMT) gene as a candidate for psychiatric phenotypes : evidence and lessons by CRADDOCK, N, OWEN, M. J, O'DONOVAN, M. C

“…The enzyme catechol-O-methyl transferase (COMT), identified in the 1950s, is involved in catabolism of monoamines that are influenced by psychotropic…”
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Common alleles contribute to schizophrenia in CNV carriers by Tansey, K E, Rees, E, Linden, D E, Ripke, S, Chambert, K D, Moran, J L, McCarroll, S A, Holmans, P, Kirov, G, Walters, J, Owen, M J, O'Donovan, M C

“…The genetic architecture of schizophrenia is complex, involving risk alleles ranging from common alleles of weak effect to rare alleles of large effect, the…”
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Replication of bipolar disorder susceptibility alleles and identification of two novel genome-wide significant associations in a new bipolar disorder case–control sample by Green, E K, Hamshere, M, Forty, L, Gordon-Smith, K, Fraser, C, Russell, E, Grozeva, D, Kirov, G, Holmans, P, Moran, J L, Purcell, S, Sklar, P, Owen, M J, O'Donovan, M C, Jones, L, Jones, I R, Craddock, N

“…We have conducted a genotyping study using a custom Illumina Infinium HD genotyping array, the ImmunoChip, in a new UK sample of 1218 bipolar disorder (BD)…”
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Gene-wide analyses of genome-wide association data sets: evidence for multiple common risk alleles for schizophrenia and bipolar disorder and for overlap in genetic risk by Moskvina, V, Craddock, N, Holmans, P, Nikolov, I, Pahwa, J S, Green, E, Owen, M J, O'Donovan, M C

“…Genome-wide association (GWAS) analyses have identified susceptibility loci for many diseases, but most risk for any complex disorder remains unattributed…”
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The bipolar disorder risk allele at CACNA1C also confers risk of recurrent major depression and of schizophrenia by Green, E K, Grozeva, D, Jones, I, Jones, L, Kirov, G, Caesar, S, Gordon-Smith, K, Fraser, C, Forty, L, Russell, E, Hamshere, M L, Moskvina, V, Nikolov, I, Farmer, A, McGuffin, P, Holmans, P A, Owen, M J, O'Donovan, M C, Craddock, N

“…Molecular genetic analysis offers opportunities to advance our understanding of the nosological relationship between psychiatric diagnostic categories in…”
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Schizophrenia genetics: emerging themes for a complex disorder by Kavanagh, D H, Tansey, K E, O'Donovan, M C, Owen, M J

“…After two decades of frustration, genetic studies of schizophrenia have entered an era of spectacular success. Advances in genotyping technologies and high…”
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Genome-wide common and rare variant analysis provides novel insights into clozapine-associated neutropenia by Legge, S E, Hamshere, M L, Ripke, S, Pardinas, A F, Goldstein, J I, Rees, E, Richards, A L, Leonenko, G, Jorskog, L F, Chambert, K D, Collier, D A, Genovese, G, Giegling, I, Holmans, P, Jonasdottir, A, Kirov, G, McCarroll, S A, MacCabe, J H, Mantripragada, K, Moran, J L, Neale, B M, Stefansson, H, Rujescu, D, Daly, M J, Sullivan, P F, Owen, M J, O'Donovan, M C, Walters, J T R

“…The antipsychotic clozapine is uniquely effective in the management of schizophrenia; however, its use is limited by its potential to induce agranulocytosis…”
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Schizophrenia: genes at last? by Owen, M.J., Craddock, N., O'Donovan, M.C.

“…Genetic epidemiological studies suggest that individual variation in susceptibility to schizophrenia is largely genetic, reflecting alleles of moderate to…”
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Hypothesis-driven candidate genes for schizophrenia compared to genome-wide association results by Collins, A L, Kim, Y, Sklar, P, O'Donovan, M C, Sullivan, P F

“…Candidate gene studies have been a key approach to the genetics of schizophrenia (SCZ). However, the results of these studies are confusing and no genes have…”
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Genetic risk for schizophrenia is associated with increased proportion of indirect connections in brain networks revealed by a semi-metric analysis: evidence from population sample stratified for polygenic risk by Dimitriadis, S I, Perry, G, Lancaster, T M, Tansey, K E, Singh, K D, Holmans, P, Pocklington, A, Davey Smith, G, Zammit, S, Hall, J, O’Donovan, M C, Owen, M J, Jones, D K, Linden, D E

“…Abstract Research studies based on tractography have revealed a prominent reduction of asymmetry in some key white-matter tracts in schizophrenia (SCZ)…”
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The molecular genetics of schizophrenia: new findings promise new insights by OWEN, M. J, WILLIAMS, N. M, O'DONOVAN, M. C

“…The high heritability of schizophrenia has stimulated much work aimed at identifying susceptibility genes using positional genetics. However, difficulties in…”
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