Search Results - "O’Donoghue, J"

IL-33-mediated mast cell activation promotes gastric cancer through macrophage mobilization by Eissmann, Moritz F., Dijkstra, Christine, Jarnicki, Andrew, Phesse, Toby, Brunnberg, Jamina, Poh, Ashleigh R., Etemadi, Nima, Tsantikos, Evelyn, Thiem, Stefan, Huntington, Nicholas D., Hibbs, Margaret L., Boussioutas, Alex, Grimbaldeston, Michele A., Buchert, Michael, O’Donoghue, Robert J. J., Masson, Frederick, Ernst, Matthias

“…The contribution of mast cells in the microenvironment of solid malignancies remains controversial. Here we functionally assess the impact of tumor-adjacent,…”
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Mechanisms of outer membrane vesicle entry into host cells by O'Donoghue, Eloise J., Krachler, Anne Marie

“…Bacterial outer membrane vesicles (OMVs) are nano‐sized compartments consisting of a lipid bilayer that encapsulates periplasm‐derived, luminal content. OMVs,…”
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Pathogen-derived extracellular vesicles mediate virulence in the fatal human pathogen Cryptococcus gattii by Bielska, Ewa, Sisquella, Marta Arch, Aldeieg, Maha, Birch, Charlotte, O’Donoghue, Eloise J., May, Robin C.

“…The Pacific Northwest outbreak of cryptococcosis, caused by a near-clonal lineage of the fungal pathogen Cryptococcus gattii , represents the most significant…”
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Cathepsin B in neurodegeneration of Alzheimer's disease, traumatic brain injury, and related brain disorders by Hook, Vivian, Yoon, Michael, Mosier, Charles, Ito, Gen, Podvin, Sonia, Head, Brian P., Rissman, Robert, O'Donoghue, Anthony J., Hook, Gregory

“…Investigations of Alzheimer's disease (AD), traumatic brain injury (TBI), and related brain disorders have provided extensive evidence for involvement of…”
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Lipopolysaccharide structure impacts the entry kinetics of bacterial outer membrane vesicles into host cells by O'Donoghue, Eloise J, Sirisaengtaksin, Natalie, Browning, Douglas F, Bielska, Ewa, Hadis, Mohammed, Fernandez-Trillo, Francisco, Alderwick, Luke, Jabbari, Sara, Krachler, Anne Marie

“…Outer membrane vesicles are nano-sized microvesicles shed from the outer membrane of Gram-negative bacteria and play important roles in immune priming and…”
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Global upper-atmospheric heating on Jupiter by the polar aurorae by O’Donoghue, J., Moore, L., Bhakyapaibul, T., Melin, H., Stallard, T., Connerney, J. E. P., Tao, C.

“…Jupiter’s upper atmosphere is considerably hotter than expected from the amount of sunlight that it receives 1 – 3 . Processes that couple the magnetosphere to…”
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Estimating the financial cost of chronic kidney disease to the NHS in England by Kerr, Marion, Bray, Benjamin, Medcalf, James, O'Donoghue, Donal J, Matthews, Beverley

“…Chronic kidney disease (CKD) is a major challenge for health care systems around the world, and the prevalence rates appear to be increasing. We estimate the…”
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A single-cell RNA-seq atlas of Schistosoma mansoni identifies a key regulator of blood feeding by Wendt, George, Zhao, Lu, Chen, Rui, Liu, Chenxi, O'Donoghue, Anthony J, Caffrey, Conor R, Reese, Michael L, Collins, 3rd, James J

“…Schistosomiasis is a neglected tropical disease that infects 240 million people. With no vaccines and only one drug available, new therapeutic targets are…”
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Structure- and function-based design of Plasmodium-selective proteasome inhibitors by Li, Hao, O’Donoghue, Anthony J., van der Linden, Wouter A., Xie, Stanley C., Yoo, Euna, Foe, Ian T., Tilley, Leann, Craik, Charles S., da Fonseca, Paula C. A., Bogyo, Matthew

“…Structural and functional characterizations show that the specificity of the Plasmodium falciparum proteasome is sufficiently unique from that of the human…”
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Vaginal Tritrichomonas foetus infection in mice as an in vivo model for drug development against Trichomonas vaginalis by Nieskens, Noelle M, Miyamoto, Yukiko, Hurysz, Brianna M, O'Donoghue, Anthony J, Eckmann, Lars

“…Trichomonas vaginalis is the causative agent of the common sexually transmitted disease, trichomoniasis, which affects more than a hundred million people…”
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Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care by Davison, Sara N, Levin, Adeera, Moss, Alvin H, Jha, Vivekanand, Brown, Edwina A, Brennan, Frank, Murtagh, Fliss E M, Naicker, Saraladevi, Germain, Michael J, O'Donoghue, Donal J, Morton, Rachael L, Obrador, Gregorio T

“…Patients with advanced chronic kidney disease (CKD) have a high burden of physical and psychosocial symptoms, poor outcomes, and high costs of care. Current…”
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A Dual‐Color Fluorescent Probe Allows Simultaneous Imaging of Main and Papain‐like Proteases of SARS‐CoV‐2‐Infected Cells for Accurate Detection and Rapid Inhibitor Screening by Cheng, Yong, Borum, Raina M., Clark, Alex E., Jin, Zhicheng, Moore, Colman, Fajtová, Pavla, O'Donoghue, Anthony J., Carlin, Aaron F., Jokerst, Jesse V.

“…The main protease (Mpro) and papain‐like protease (PLpro) play critical roles in SARS‐CoV‐2 replication and are promising targets for antiviral inhibitors. The…”
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Global substrate profiling of proteases in human neutrophil extracellular traps reveals consensus motif predominantly contributed by elastase by O'Donoghue, Anthony J, Jin, Ye, Knudsen, Giselle M, Perera, Natascha C, Jenne, Dieter E, Murphy, John E, Craik, Charles S, Hermiston, Terry W

“…Neutrophil extracellular traps (NETs) consist of antimicrobial molecules embedded in a web of extracellular DNA. Formation of NETs is considered to be a…”
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The new AASM criteria for scoring hypopneas: impact on the apnea hypopnea index by Ruehland, Warren R, Rochford, Peter D, O'Donoghue, Fergal J, Pierce, Robert J, Singh, Parmjit, Thornton, Andrew T

“…To compare apnea-hypopnea indices (AHIs) derived using 3 standard hypopnea definitions published by the American Academy of Sleep Medicine (AASM); and to…”
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Early chronic kidney disease: diagnosis, management and models of care by Wouters, Olivier J., O'Donoghue, Donal J., Ritchie, James, Kanavos, Panos G., Narva, Andrew S.

“…Key Points Chronic kidney disease (CKD) is associated with early-onset cardiovascular disease, end-stage renal disease and premature death Patients with…”
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Selective Neutral pH Inhibitor of Cathepsin B Designed Based on Cleavage Preferences at Cytosolic and Lysosomal pH Conditions by Yoon, Michael C, Solania, Angelo, Jiang, Zhenze, Christy, Mitchell P, Podvin, Sonia, Mosier, Charles, Lietz, Christopher B, Ito, Gen, Gerwick, William H, Wolan, Dennis W, Hook, Gregory, O’Donoghue, Anthony J, Hook, Vivian

“…Cathepsin B is a cysteine protease that normally functions within acidic lysosomes for protein degradation, but in numerous human diseases, cathepsin B…”
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Small molecule in situ resin capture provides a compound first approach to natural product discovery by Bogdanov, Alexander, Salib, Mariam N., Chase, Alexander B., Hammerlindl, Heinz, Muskat, Mitchell N., Luedtke, Stephanie, da Silva, Elany Barbosa, O’Donoghue, Anthony J., Wu, Lani F., Altschuler, Steven J., Molinski, Tadeusz F., Jensen, Paul R.

“…Culture-based microbial natural product discovery strategies fail to realize the extraordinary biosynthetic potential detected across earth’s microbiomes. Here…”
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Peptidic Sulfhydryl for Interfacing Nanocrystals and Subsequent Sensing of SARS-CoV‑2 Protease by Jin, Zhicheng, Yeung, Justin, Zhou, Jiajing, Cheng, Yong, Li, Yi, Mantri, Yash, He, Tengyu, Yim, Wonjun, Xu, Ming, Wu, Zhuohong, Fajtova, Pavla, Creyer, Matthew N, Moore, Colman, Fu, Lei, Penny, William F, O’Donoghue, Anthony J, Jokerst, Jesse V

“…There is a need for surveillance of COVID-19 to identify individuals infected with SARS-CoV-2 coronavirus. Although specific, nucleic acid testing has…”
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Saturn's Weather‐Driven Aurorae Modulate Oscillations in the Magnetic Field and Radio Emissions by Chowdhury, M. N., Stallard, T. S., Baines, K. H., Provan, G., Melin, H., Hunt, G. J., Moore, L., O’Donoghue, J., Thomas, E. M., Wang, R., Miller, S., Badman, S. V.

“…The Cassini spacecraft revealed that Saturn's magnetic field displayed oscillations at a period originally thought to match the planetary rotation rate but…”
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Development of a Potent Inhibitor of the Plasmodium Proteasome with Reduced Mammalian Toxicity by LaMonte, Gregory M, Almaliti, Jehad, Bibo-Verdugo, Betsaida, Keller, Lena, Zou, Bing Yu, Yang, Jennifer, Antonova-Koch, Yevgeniya, Orjuela-Sanchez, Pamela, Boyle, Colleen A, Vigil, Edgar, Wang, Lawrence, Goldgof, Gregory M, Gerwick, Lena, O’Donoghue, Anthony J, Winzeler, Elizabeth A, Gerwick, William H, Ottilie, Sabine

“…Naturally derived chemical compounds are the foundation of much of our pharmacopeia, especially in antiproliferative and anti-infective drug classes. Here, we…”
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