Search Results - "O’Donoghue, C."

Going Full Circle with Organocatalysis and Biocatalysis: The Latent Potential of Cofactor Mimics in Asymmetric Synthesis by Murray, Jacob, Hodgson, David R. W., O’Donoghue, AnnMarie C.

“…Many enzymes work in tandem with small molecule cofactors, which have inspired organocatalyst designs. Chemical modification of cofactor scaffolds has…”
Get full text

The impact of interactive advertising on consumer engagement, recall, and understanding: A scoping systematic review for informing regulatory science by Giombi, Kristen, Viator, Catherine, Hoover, Juliana, Tzeng, Janice, Sullivan, Helen W, O'Donoghue, Amie C, Southwell, Brian G, Kahwati, Leila C

“…We conducted a scoping systematic review with respect to how consumer engagement with interactive advertising is evaluated and if interactive features…”
Get full text

Recognising the benefits and harms of breast cancer screening: an opportunity to target improvement by O'Donoghue, C, Esserman, L

Get full text

Resilience and Innovation: Reflection on Critical Care Nursing Through the COVID-19 Era by DiLibero, Justin H., O’Donoghue, Sharon C.

Get full text

Rate and equilibrium constants for the addition of triazolium salt derived N-heterocyclic carbenes to heteroaromatic aldehydes by Duan, Zhuan, Young, Claire M, Zhu, Jiayun, Slawin, Alexandra M. Z, O'Donoghue, AnnMarie C, Smith, Andrew D

“…Heteroaromatic aldehydes are often used preferentially or exclusively in a range of NHC-catalysed processes that proceed through the generation of a reactive…”
Get full text

pKa Values of Chiral Brønsted Acid Catalysts: Phosphoric Acids/Amides, Sulfonyl/Sulfuryl Imides, and Perfluorinated TADDOLs (TEFDDOLs) by Christ, Philipp, Lindsay, Anita G., Vormittag, Sonja S., Neudörfl, Jörg-M., Berkessel, Albrecht, O'Donoghue, AnnMarie C.

“…Measure what is measurable, and make measurable what is not so! This timeless quotation by Galileo forms the basis of all quantitative understanding, including…”
Get full text

Patients’ understanding of oncology clinical endpoints: A literature review by Boudewyns, Vanessa, Southwell, Brian G., DeFrank, Jessica T., Ferriola-Bruckenstein, Kate, Halpern, Michael T., O’Donoghue, Amie C., Sullivan, Helen W.

“…•We reviewed the literature on patient understanding of oncology clinical endpoints.•Available literature (13 articles) yields little information on this…”
Get full text

Comparison of the Glidescope®, the Pentax AWS®, and the Truview EVO2® with the Macintosh laryngoscope in experienced anaesthetists: a manikin study by Malik, M.A., O’Donoghue, C., Carney, J., Maharaj, C.H., Harte, B.H., Laffey, J.G.

“…The Pentax Airwayscope®, the Glidescope®, and the Truview EVO2® constitute three novel laryngoscopes that facilitate visualization of the vocal cords without…”
Get full text

Enzyme Architecture: The Effect of Replacement and Deletion Mutations of Loop 6 on Catalysis by Triosephosphate Isomerase by Zhai, Xiang, Go, Maybelle K, O’Donoghue, AnnMarie C, Amyes, Tina L, Pegan, Scott D, Wang, Yan, Loria, J. Patrick, Mesecar, Andrew D, Richard, John P

“…Two mutations of the phosphodianion gripper loop in chicken muscle triosephosphate isomerase (cTIM) were examined: (1) the loop deletion mutant (LDM) formed by…”
Get full text

Physicians' Understanding of Clinical Trial Data in Professional Prescription Drug Promotion by Moynihan, Caitlin K, Burke, Panne A, Evans, Sarah A, O'Donoghue, Amie C, Sullivan, Helen W

“…Prescription drug marketing to physicians often includes clinical trial data. Prior research has shown that physicians may not have the necessary knowledge to…”
Get full text

Rate and Equilibrium Constants for the Addition of N-Heterocyclic Carbenes into Benzaldehydes: A Remarkable 2-Substituent Effect by Collett, Christopher J., Massey, Richard S., Taylor, James E., Maguire, Oliver R., O'Donoghue, AnnMarie C., Smith, Andrew D.

“…Rate and equilibrium constants for the reaction between N‐aryl triazolium N‐heterocyclic carbene (NHC) precatalysts and substituted benzaldehyde derivatives to…”
Get full text

Kinetic and Structure‐Activity Studies of the Triazolium Ion‐ Catalyzed Intramolecular Stetter Reaction by Collett, Christopher J., Young, Claire M., Massey, Richard S., O'Donoghue, AnnMarie C., Smith, Andrew D.

“…Mechanistic studies of the triazolium ion‐catalyzed intramolecular Stetter reaction using initial rates analysis in NEt3/NEt3 ⋅ HCl buffered methanol showed…”
Get full text

Triazolium Salt Organocatalysis: Mechanistic Evaluation of Unusual Ortho-Substituent Effects on Deprotonation by Peter Quinn, Matthew S. Smith, Jiayun Zhu, David R. W. Hodgson, AnnMarie C. O’Donoghue

“…Organocatalysis by N-heterocyclic carbenes is normally initiated by the deprotonation of precursor azolium ions to form active nucleophilic species…”
Get full text

Peer-Generated Health Information: The Role of Online Communities in Patient and Caregiver Health Decisions by Rupert, Douglas J., Gard Read, Jennifer, Amoozegar, Jacqueline B., Moultrie, Rebecca R., Taylor, Olivia M., O'Donoghue, Amie C., Sullivan, Helen W.

“…Individuals increasingly access peer-generated health information (PGHI) through social media, especially online health communities (OHCs). Previous research…”
Get full text

Application of a decision analytic framework for adoption of clinical trial results: are the data regarding TARGIT-A IORT ready for prime time? by Esserman, L. J., Alvarado, M. D., Howe, R. J., Mohan, A. J., Harrison, B., Park, C., O’Donoghue, C., Ozanne, E. M.

“…The results from randomized clinical trials are often adopted slowly. This practice potentially prevents many people from benefiting from more effective care…”
Get full text

The impact of agricultural knowledge transfer resources on farm level profitability during the economic recession - a quantitative study by Cawley, A., O'Donoghue, C., Heanue, K., Hilliard, R., Sheehan, M.

“…Purpose: The impact of agricultural knowledge transfer (KT) is related to the access to and the quality of services available. Within this context, the…”
Get full text

Effects of comparative claims in prescription drug direct-to-consumer advertising on consumer perceptions and recall by O'Donoghue, Amie C., Williams, Pamela A., Sullivan, Helen W., Boudewyns, Vanessa, Squire, Claudia, Willoughby, Jessica Fitts

“…Although pharmaceutical companies cannot make comparative claims in direct-to-consumer (DTC) ads for prescription drugs without substantial evidence, the U.S…”
Get full text

An Innovative Approach to Improving the Accuracy of Delirium Assessments Using the Confusion Assessment Method for the Intensive Care Unit by DiLibero, Justin, O’Donoghue, Sharon C, DeSanto-Madeya, Susan, Felix, Janice, Ninobla, Annalyn, Woods, Allison

“…BACKGROUND:Delirium occurs in up to 80% of intensive care unit (ICU) patients. Despite its prevalence in this population, there continues to be inaccuracies in…”
Get full text

Improving the Accuracy of Delirium Assessments in Neuroscience Patients: Scaling a Quality Improvement Program to Improve Nurses’ Skill, Compliance, and Accuracy in the Use of the Confusion Assessment Method in the Intensive Care Unit Tool by DiLibero, Justin, DeSanto-Madeya, Susan, Dottery, Rachael, Sullivan, Lauren, O’Donoghue, Sharon C

“…BACKGROUND:Delirium affects up to 80% of critically ill patients; however, many cases of delirium go unrecognized because of inaccurate assessments. The…”
Get full text

Unusually high α-proton acidity of prolyl residues in cyclic peptides by Maguire, Oliver R, Taylor, Bethany, Higgins, Eleanor M, Rees, Matthew, Cobb, Steven L, Simpkins, Nigel S, Hayes, Christopher J, O'Donoghue, AnnMarie C

“…The acidity of the α-proton in peptides has an essential role in numerous biochemical reactions and underpins their stereochemical integrity, which is critical…”
Get full text