Search Results - "O’Connor, Paul"

Alkali supplementation as a therapeutic in chronic kidney disease: what mediates protection? by Mannon, Elinor C, O'Connor, Paul M

“…Sodium bicarbonate (NaHCO ) has been recognized as a possible therapy to target chronic kidney disease (CKD) progression. Several small clinical trials have…”
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New mechanisms for the kidney-protective effect of alkali in chronic kidney disease by O'Connor, Paul M, Mannon, Elinor C

“…Worldwide, more than one in ten adults are estimated to have chronic kidney disease (CKD). As CKD progresses, both the cost of treatment and associated risk of…”
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A systematic review of 7 years of research on entrustable professional activities in graduate medical education, 2011–2018 by O'Dowd, Emily, Lydon, Sinéad, O'Connor, Paul, Madden, Caoimhe, Byrne, Dara

“…Purpose This review aimed to synthesise some of the extant work on the use of entrustable professional activities (EPAs) for postgraduate physicians, to assess…”
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Greater high-mobility group box 1 in male compared with female spontaneously hypertensive rats worsens renal ischemia-reperfusion injury by Mohamed, Riyaz, Rafikova, Olga, O'Connor, Paul M, Sullivan, Jennifer C

“…Renal ischemia is the most common cause of acute kidney injury. Damage-associated molecular patterns (DAMPs) initiate an inflammatory response and contribute…”
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Necrosis Contributes to the Development of Hypertension in Male, but Not Female, Spontaneously Hypertensive Rats by Abdelbary, Mahmoud, Rafikova, Olga, Gillis, Ellen E., Musall, Jacqueline B., Baban, Babak, O’Connor, Paul M., Brands, Michael W., Sullivan, Jennifer C.

“…Necrosis is a pathological form of cell death that induces an inflammatory response, and immune cell activation contributes to the development and maintenance…”
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NaHCO3 loading causes increased arterial pressure and kidney damage in rats with chronic kidney disease by Mannon, Elinor C, Muller, P Robinson, Sun, Jingping, Bush, Weston B, Coleman, Alex, Ocasio, Hiram, Polichnowski, Aaron J, Brands, Michael W, O'Connor, Paul M

“…Sodium bicarbonate (NaHCO3) is commonly utilized as a therapeutic to treat metabolic acidosis in people with chronic kidney disease (CKD). While increased…”
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Physiological and performance responses of sprint interval training and endurance training in Gaelic football players by Kelly, David T., Cregg, Cathal J., O’Connor, Paul L., Cullen, Bryan D., Moyna, Niall M.

“…Purpose While ideal for developing aerobic capacity, traditional endurance training (ET) is extremely time-consuming and may lack the specificity to maintain…”
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Oral teriflunomide for patients with a first clinical episode suggestive of multiple sclerosis (TOPIC): a randomised, double-blind, placebo-controlled, phase 3 trial by Miller, Aaron E, Prof, Wolinsky, Jerry S, Prof, Kappos, Ludwig, MD, Comi, Giancarlo, Prof, Freedman, Mark S, Prof, Olsson, Tomas P, Prof, Bauer, Deborah, MS, Benamor, Myriam, MD, Truffinet, Philippe, MD, O'Connor, Paul W, Prof

“…Summary Background Teriflunomide is a once-daily oral immunomodulator approved for the treatment of relapsing-remitting multiple sclerosis. We aimed to assess…”
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Reactive oxygen species as important determinants of medullary flow, sodium excretion, and hypertension by Cowley, Jr, Allen W, Abe, Michiaki, Mori, Takefumi, O'Connor, Paul M, Ohsaki, Yusuke, Zheleznova, Nadezhda N

“…The physiological evidence linking the production of superoxide, hydrogen peroxide, and nitric oxide in the renal medullary thick ascending limb of Henle…”
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Out of the Cold: Does the Immunoproteasome Play a Role in Kidney Graft Function after Cold Storage? by O'Connor, Paul M

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Differential release of extracellular vesicle tRNA from oxidative stressed renal cells and ischemic kidneys by Lee, Hee Kyung, Lee, Byung Rho, Lee, Tae Jin, Lee, Chang Min, Li, Chenglong, O’Connor, Paul M., Dong, Zheng, Kwon, Sang-Ho

“…While urine-based liquid biopsy has expanded to the analyses of extracellular nucleic acids, the potential of transfer RNA (tRNA) encapsulated within…”
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Aldosterone Antagonism Is More Effective at Reducing Blood Pressure and Excessive Renal ENaC Activity in AngII-Infused Female Rats Than in Males by Buncha, Vadym, Cherezova, Alena, Alexander, Sati, Baranovskaya, Irina, Coleman, Kathleen A, Cherian-Shaw, Mary, Brands, Michael W, Sullivan, Jennifer C, O'Connor, Paul M, Mamenko, Mykola

“…AngII (angiotensin II)-dependent hypertension causes comparable elevations of blood pressure (BP), aldosterone levels, and renal ENaC (epithelial Na channel)…”
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Ischemic Renal Injury: Can Renal Anatomy and Associated Vascular Congestion Explain Why the Medulla and Not the Cortex Is Where the Trouble Starts? by Ray, Sarah C., Mason, June, O'Connor, Paul M.

“…The kidneys receive approximately 20% of cardiac output and have a low fractional oxygen extraction. Quite paradoxically, however, the kidneys are highly…”
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Delayed Reperfusion of the Renal Outer Medulla Attenuates Ischemia Reperfusion‐Induced Vascular Congestion by McLarnon, Sarah R., Sun, Jingping, O'Connor, Paul M.

“…Vascular congestion, or red blood cell (RBC) trapping, of the renal outer medulla (OM) is a common finding in acute tubular necrosis caused by ischemia…”
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NaCl Intake Promotes Greater Increases in Blood Pressure Than NaHCO 3 in Rats with Chronic Kidney Disease by Mannon, Elinor C, O'Connor, Paul M

“…Sodium bicarbonate (NaHCO ) is used in patients with chronic kidney disease (CKD) to treat metabolic acidosis and slow CKD progression. One potential adverse…”
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Developmental Exposure to Endocrine Disruptors Expands Murine Myometrial Stem Cell Compartment as a Prerequisite to Leiomyoma Tumorigenesis by Mas, Aymara, Stone, Leyland, O'Connor, Paul M., Yang, Qiwei, Kleven, Daniel, Simon, Carlos, Walker, Cheryl L., Al‐Hendy, Ayman

“…Despite the high prevalence and major negative impact of uterine fibroids (UFs) on women's health, their pathogenesis remains largely unknown. While…”
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Effect of natalizumab on clinical and radiological disease activity in multiple sclerosis: a retrospective analysis of the Natalizumab Safety and Efficacy in Relapsing-Remitting Multiple Sclerosis (AFFIRM) study by Havrdova, Eva, MD, Galetta, Steven, MD, Hutchinson, Michael, MD, Stefoski, Dusan, MD, Bates, David, MD, Polman, Chris H, MD, O'Connor, Paul W, MD, Giovannoni, Gavin, PhD, Phillips, J Theodore, MD, Lublin, Fred D, MD, Pace, Amy, ScD, Kim, Richard, MD, Hyde, Robert, PhD

“…Summary Background The efficacy of natalizumab on clinical and radiological measures in the phase III Natalizumab Safety and Efficacy in Relapsing-Remitting…”
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Identification of novel macropinocytosis inhibitors using a rational screen of Food and Drug Administration‐approved drugs by Lin, Hui‐Ping, Singla, Bhupesh, Ghoshal, Pushpankur, Faulkner, Jessica L, Cherian‐Shaw, Mary, O'Connor, Paul M, She, Jin‐Xiong, Belin de Chantemele, Eric J, Csányi, Gábor

“…Background and Purpose Macropinocytosis is involved in many pathologies, including cardiovascular disorders, cancer, allergic diseases, viral and bacterial…”
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Vasa recta pericyte density is negatively associated with vascular congestion in the renal medulla following ischemia reperfusion in rats by Crislip, G Ryan, O'Connor, Paul M, Wei, Qingqing, Sullivan, Jennifer C

“…Recent evidence suggests that a greater density of pericytes in renal cadaveric allografts is associated with better recovery following transplant. The…”
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Oral NaHCO3 Activates a Splenic Anti-Inflammatory Pathway: Evidence That Cholinergic Signals Are Transmitted via Mesothelial Cells by Ray, Sarah C., Baban, Babak, Tucker, Matthew A., Seaton, Alec J., Chang, Kyu Chul, Mannon, Elinor C., Sun, Jingping, Patel, Bansari, Wilson, Katie, Musall, Jacqueline B., Ocasio, Hiram, Irsik, Debra, Filosa, Jessica A., Sullivan, Jennifer C., Marshall, Brendan, Harris, Ryan A., O’Connor, Paul M.

“…Abstract We tested the hypothesis that oral NaHCO3 intake stimulates splenic anti-inflammatory pathways. Following oral NaHCO3 loading, macrophage polarization…”
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