Search Results - "O’Connor, J. J."

Targeting the DNA Damage Response in Cancer by O’Connor, Mark J.

“…An underlying hallmark of cancers is their genomic instability, which is associated with a greater propensity to accumulate DNA damage. Historical treatment of…”
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Distinguishing genetic correlation from causation across 52 diseases and complex traits by O’Connor, Luke J., Price, Alkes L.

“…Mendelian randomization, a method to infer causal relationships, is confounded by genetic correlations reflecting shared etiology. We developed a model in…”
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Laying a trap to kill cancer cells: PARP inhibitors and their mechanisms of action by Pommier, Yves, O'Connor, Mark J, de Bono, Johann

“…Poly(ADP-ribose) polymerase (PARP) inhibitors are the first DNA damage response targeted agents approved for cancer therapy. Here, we focus on their molecular…”
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The distribution of common-variant effect sizes by O’Connor, Luke J.

“…The genetic effect-size distribution of a disease describes the number of risk variants, the range of their effect sizes and sample sizes that will be required…”
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Impacts of land management practices on blue carbon stocks and greenhouse gas fluxes in coastal ecosystems—A meta‐analysis by O’Connor, J. Jack, Fest, Benedikt J., Sievers, Michael, Swearer, Stephen E.

“…Global recognition of climate change and its predicted consequences has created the need for practical management strategies for increasing the ability of…”
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Political correctness and the alt-right: The development of extreme political attitudes by Moss, Jordan T, O'Connor, Peter J

“…Recent studies have documented a shift from moderate political attitudes to more extreme attitudes at the ends of the political spectrum. This can be seen in…”
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1000 dams down and counting by O'Connor, J. E., Duda, J. J., Grant, G. E.

“…Dam removals are reconnecting rivers in the United States Forty years ago, the demolition of large dams was mostly fiction, notably plotted in Edward Abbey's…”
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Postdischarge symptoms and rehabilitation needs in survivors of COVID‐19 infection: A cross‐sectional evaluation by Halpin, Stephen J., McIvor, Claire, Whyatt, Gemma, Adams, Anastasia, Harvey, Olivia, McLean, Lyndsay, Walshaw, Christopher, Kemp, Steven, Corrado, Joanna, Singh, Rajinder, Collins, Tamsin, O'Connor, Rory J., Sivan, Manoj

“…Background There is currently very limited information on the nature and prevalence of post‐COVID‐19 symptoms after hospital discharge. Methods A purposive…”
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The Measurement of Emotional Intelligence: A Critical Review of the Literature and Recommendations for Researchers and Practitioners by O'Connor, Peter J, Hill, Andrew, Kaya, Maria, Martin, Brett

“…Emotional Intelligence (EI) emerged in the 1990s as an ability based construct analogous to general Intelligence. However, over the past 3 decades two further,…”
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Subjective Responses to Alcohol in the Development and Maintenance of Alcohol Use Disorder by King, Andrea, Vena, Ashley, Hasin, Deborah S, deWit, Harriet, O’Connor, Sean J, Cao, Dingcai

“…Objective: Alcohol use disorder (AUD) remains an urgent public health problem. Longitudinal data are needed to clarify the role of acute subjective responses…”
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Quantifying genetic effects on disease mediated by assayed gene expression levels by Yao, Douglas W., O’Connor, Luke J., Price, Alkes L., Gusev, Alexander

“…Disease variants identified by genome-wide association studies (GWAS) tend to overlap with expression quantitative trait loci (eQTLs), but it remains unclear…”
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Effects of Arsenic on Gut Microbiota and Its Biotransformation Genes in Earthworm Metaphire sieboldi by Wang, Hong-Tao, Zhu, Dong, Li, Gang, Zheng, Fei, Ding, Jing, O’Connor, Patrick J, Zhu, Yong-Guan, Xue, Xi-Mei

“…Arsenic biotransformation mediated by gut microbiota can affect arsenic bioavailability and microbial community. Arsenic species, arsenic biotransformation…”
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Generation of Axially Chiral Fluoroallenes through a Copper-Catalyzed Enantioselective β‑Fluoride Elimination by O’Connor, Thomas J, Mai, Binh Khanh, Nafie, Jordan, Liu, Peng, Toste, F. Dean

“…Herein we report the copper-catalyzed silylation of propargylic difluorides to generate axially chiral, tetrasubstituted monofluoroallenes in both good yields…”
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Spider-silk inspired polymeric networks by harnessing the mechanical potential of β-sheets through network guided assembly by Chan, Nicholas Jun-An, Gu, Dunyin, Tan, Shereen, Fu, Qiang, Pattison, Thomas Geoffrey, O’Connor, Andrea J., Qiao, Greg G.

“…The high toughness of natural spider-silk is attributed to their unique β-sheet secondary structures. However, the preparation of mechanically strong β-sheet…”
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Targeting the replication stress response in cancer by Forment, Josep V., O’Connor, Mark J.

“…Many conventional chemotherapies used in cancer treatment exert their effect by inflicting DNA damage. Highly proliferative tissues, as well as tumour cells,…”
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Extreme Polygenicity of Complex Traits Is Explained by Negative Selection by O'Connor, Luke J., Schoech, Armin P., Hormozdiari, Farhad, Gazal, Steven, Patterson, Nick, Price, Alkes L.

“…Complex traits and common diseases are extremely polygenic, their heritability spread across thousands of loci. One possible explanation is that thousands of…”
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Harnessing the patient voice in real-world evidence: the essential role of patient-reported outcomes by Calvert, Melanie J., O’Connor, Daniel J., Basch, Ethan M.

“…Real-world evidence is increasingly valued by regulators and payers. Central to this evidence base is patient-reported outcome data describing the impact of…”
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Circulating exosomes deliver free fatty acids from the bloodstream to cardiac cells: Possible role of CD36 by Garcia, N A, González-King, H, Grueso, E, Sánchez, R, Martinez-Romero, A, Jávega, B, O'Connor, J E, Simons, P J, Handberg, A, Sepúlveda, P

“…Regulation of circulating free fatty acid (FFA) levels and delivery is crucial to maintain tissue homeostasis. Exosomes are nanomembranous vesicles that are…”
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PARP Inhibitors: Extending Benefit Beyond BRCA -Mutant Cancers by Pilié, Patrick G, Gay, Carl M, Byers, Lauren A, O'Connor, Mark J, Yap, Timothy A

“…A mounting body of evidence now indicates that PARP inhibitors have the potential to be used as a foundation for both monotherapy and combination strategies…”
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NSAID therapy effects on healing of bone, tendon, and the enthesis by Su, Bailey, O'Connor, J Patrick

“…Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of skeletal injuries. The ability of NSAIDs to reduce pain and inflammation…”
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