Search Results - "O’Connor, Gemma"

Enhanced El Niño–Southern Oscillation Variability in Recent Decades by Grothe, Pamela R., Cobb, Kim M., Liguori, Giovanni, Di Lorenzo, Emanuele, Capotondi, Antonietta, Lu, Yanbin, Cheng, Hai, Edwards, R. Lawrence, Southon, John R., Santos, Guaciara M., Deocampo, Daniel M., Lynch‐Stieglitz, Jean, Chen, Tianran, Sayani, Hussein R., Thompson, Diane M., Conroy, Jessica L., Moore, Andrea L., Townsend, Kayla, Hagos, Melat, O'Connor, Gemma, Toth, Lauren T.

“…The El Niño–Southern Oscillation (ENSO) represents the largest source of year‐to‐year global climate variability. While Earth system models suggest a range of…”
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Geophysics and Thermodynamics at South Pole Lake Indicate Stability and a Regionally Thawed Bed by Hills, Benjamin H., Christianson, Knut, Hoffman, Andrew O., Fudge, T. J., Holschuh, Nicholas, Kahle, Emma C., Conway, Howard, Christian, John E., Horlings, Annika N., O’Connor, Gemma K., Steig, Eric J.

“…Subglacial lakes require a thawed bed either now or in the past; thus, their presence and stability have implications for current and past basal conditions,…”
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A site for deep ice coring at West Hercules Dome: results from ground-based geophysics and modeling by Fudge, T. J., Hills, Benjamin H., Horlings, Annika N., Holschuh, Nicholas, Christian, John Erich, Davidge, Lindsey, Hoffman, Andrew, O'Connor, Gemma K., Christianson, Knut, Steig, Eric J.

“…Hercules Dome, Antarctica, has long been identified as a prospective deep ice core site due to the undisturbed internal layering, climatic setting and…”
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A comparison of South Pacific Antarctic sea ice and atmospheric circulation reconstructions since 1900 by Fogt, Ryan L, Dalaiden, Quentin, O'Connor, Gemma K

“…The recent changes and record lows in Antarctic sea ice extent illustrate the need for longer estimates beyond the short satellite observation period…”
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Scars of tectonism promote ice-sheet nucleation from Hercules Dome into West Antarctica by Hoffman, Andrew O., Holschuh, Nicholas, Mueller, Megan, Paden, John, Muto, Atsuhiro, Ariho, Gordon, Brigham, Cassandra, Christian, John Erich, Davidge, Lindsey, Heitmann, Emma, Hills, Benjamin, Horlings, Annika, Morey, Susannah, O’Connor, Gemma, Fudge, T. J., Steig, Eric J., Christianson, Knut

“…Geology and bed topography influence how ice sheets respond to climate change. Despite the West Antarctic Ice Sheet’s capacity to retreat and advance quickly…”
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Characteristics and rarity of the strong 1940s westerly wind event over the Amundsen Sea, West Antarctica by O'Connor, Gemma K, Holland, Paul R, Steig, Eric J, Dutrieux, Pierre, Hakim, Gregory J

“…Glaciers in the Amundsen Sea Embayment of West Antarctica are rapidly retreating and contributing to sea level rise. Ice loss is occurring primarily via…”
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Anthropogenic and internal drivers of wind changes over the Amundsen Sea, West Antarctica, during the 20th and 21st centuries by Holland, Paul R, O'Connor, Gemma K, Bracegirdle, Thomas J, Dutrieux, Pierre, Naughten, Kaitlin A, Steig, Eric J, Schneider, David P, Jenkins, Adrian, Smith, James A

“…Ocean-driven ice loss from the West Antarctic Ice Sheet is a significant contributor to sea-level rise. Recent ocean variability in the Amundsen Sea is…”
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Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells by Tivnan, Amanda, Heilinger, Tatjana, Ramsey, Joanne M, O'Connor, Gemma, Pokorny, Jenny L, Sarkaria, Jann N, Stringer, Brett W, Day, Bryan W, Boyd, Andrew W, Kim, Ella L, Lode, Holger N, Cryan, Sally-Ann, Prehn, Jochen H M

“…Aromatase is a critical enzyme in the irreversible conversion of androgens to oestrogens, with inhibition used clinically in hormone-dependent malignancies. We…”
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Strengthening Southern Hemisphere Westerlies and Amundsen Sea Low Deepening Over the 20th Century Revealed by Proxy‐Data Assimilation by O’Connor, Gemma K., Steig, Eric J., Hakim, Gregory J.

“…Winds and pressure over the Southern Ocean are critical to many aspects of the climate system, but the brevity of climate data in this region makes it…”
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Multi‐Decadal Variability of Amundsen Sea Low Controlled by Natural Tropical and Anthropogenic Drivers by Dalaiden, Quentin, Abram, Nerilie J., Goosse, Hugues, Holland, Paul R., O’Connor, Gemma K., Topál, Dániel

“…A crucial factor influencing the mass balance of the West Antarctic Ice Sheet is the Amundsen Sea Low (ASL), a climatological low‐pressure region situated off…”
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Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NFκB and Autophagy Dependent Bacillary Killing by Lawlor, Ciaran, O'Connor, Gemma, O'Leary, Seonadh, Gallagher, Paul J, Cryan, Sally-Ann, Keane, Joseph, O'Sullivan, Mary P

“…The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has…”
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Central Equatorial Pacific Warming and Freshening in the Twentieth Century: Insights From a Coral Ensemble Approach by Hitt, Nicholas T., Sayani, Hussein R., Atwood, Alyssa R., Grothe, Pamela R., Maupin, Christopher, O’Connor, Gemma K., Walter, Rachel M., Gebregiorgis, Daniel, Hardt, Madeleine E., Lu, Yanbin, Cheng, Hai, Edwards, R. Lawrence, Cobb, Kim M.

“…The tropical Pacific influences climate patterns across the globe, yet robust constraints on decadal to centennial‐scale climate variations are difficult to…”
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Coral Oxygen Isotopic Records Capture the 2015/2016 El Niño Event in the Central Equatorial Pacific by O’Connor, Gemma K., Cobb, Kim M., Sayani, Hussein R., Atwood, Alyssa R., Grothe, Pamela R., Stevenson, Samantha, Baum, Julia K., Chen, Tianran, Claar, Danielle C., Hitt, Nicholas T., Lynch-Stieglitz, Jean, Mortlock, Richard A., Schmidt, Gavin A., Walter, Rachel

“…Coral oxygen isotopes (δ^(18)O) from the central equatorial Pacific provide monthly resolved records of El Niño-Southern Oscillation activity over past…”
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Investigating the Drivers of Glacier Retreat in West Antarctica Using Proxy-Data Assimilation and Numerical Modeling by O'Connor, Gemma

“…Outlet glaciers in West Antarctica are rapidly retreating and contributing to sea level rise. Ice loss is primarily occurring via wind-driven incursions of…”
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Inhalable poly(lactic-co-glycolic acid) (PLGA) microparticles encapsulating all-trans-Retinoic acid (ATRA) as a host-directed, adjunctive treatment for Mycobacterium tuberculosis infection by O'Connor, Gemma, Krishnan, Nitya, Fagan-Murphy, Aidan, Cassidy, Joseph, O'Leary, Seonadh, Robertson, Brian D., Keane, Joseph, O'Sullivan, Mary P., Cryan, Sally-Ann

“…[Display omitted] Ending the tuberculosis (TB) epidemic by 2030 was recently listed in the United Nations (UN) Sustainable Development Goals alongside HIV/AIDS…”
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Sharpening nature's tools for efficient tuberculosis control: A review of the potential role and development of host-directed therapies and strategies for targeted respiratory delivery by O'Connor, Gemma, Gleeson, Laura E., Fagan-Murphy, Aidan, Cryan, Sally-Ann, O'Sullivan, Mary P., Keane, Joseph

“…Centuries since it was first described, tuberculosis (TB) remains a significant global public health issue. Despite ongoing holistic measures implemented by…”
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Bronchodilator effects, pharmacokinetics and safety of PSX1002-GB, a novel glycopyrronium bromide formulation, in COPD patients; a randomised crossover study by Singh, Dave, Ravi, Arjun, Reid, Frederick, Buck, Helen, O'Connor, Gemma, Down, Geoff

“…Abstract Aims To establish the dose–response relationship for pharmacodynamics (bronchodilatation), safety and pharmacokinetics of a novel particle engineered…”
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Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF[kappa]B and Autophagy Dependent Bacillary Killing by Lawlor, Ciaran, O'Connor, Gemma, O'Leary, Seonadh, Gallagher, Paul J, Cryan, Sally-Ann, Keane, Joseph, O'Sullivan, Mary P

“…The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has…”
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Treatment of Mycobacterium tuberculosis-Infected Macrophages with Poly(Lactic-Co-Glycolic Acid) Microparticles Drives NF?B and Autophagy Dependent Bacillary Killing: e0149167 by Lawlor, Ciaran, O'Connor, Gemma, O'Leary, Seonadh, Gallagher, Paul J, Cryan, Sally-Ann, Keane, Joseph, O'Sullivan, Mary P

“…The emergence of multiple-drug-resistant tuberculosis (MDR-TB) has pushed our available repertoire of anti-TB therapies to the limit of effectiveness. This has…”
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Cleared to go by O'CONNOR, GEMMA

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