Search Results - "O’Connor, Caitlin"

Selective PP2A Enhancement through Biased Heterotrimer Stabilization by Leonard, Daniel, Huang, Wei, Izadmehr, Sudeh, O’Connor, Caitlin M., Wiredja, Danica D., Wang, Zhizhi, Zaware, Nilesh, Chen, Yinghua, Schlatzer, Daniela M., Kiselar, Janna, Vasireddi, Nikhil, Schüchner, Stefan, Perl, Abbey L., Galsky, Matthew D., Xu, Wenqing, Brautigan, David L., Ogris, Egon, Taylor, Derek J., Narla, Goutham

“…Impairment of protein phosphatases, including the family of serine/threonine phosphatases designated PP2A, is essential for the pathogenesis of many diseases,…”
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Inactivation of PP2A by a recurrent mutation drives resistance to MEK inhibitors by O’Connor, Caitlin M., Leonard, Daniel, Wiredja, Danica, Avelar, Rita A., Wang, Zhizhi, Schlatzer, Daniela, Bryson, Benjamin, Tokala, Eesha, Taylor, Sarah E., Upadhyay, Aditya, Sangodkar, Jaya, Gingras, Anne-Claude, Westermarck, Jukka, Xu, Wenqing, DiFeo, Analisa, Brautigan, David L., Haider, Shozeb, Jackson, Mark, Narla, Goutham

“…The serine/threonine Protein Phosphatase 2A (PP2A) functions as a tumor suppressor by negatively regulating multiple oncogenic signaling pathways. The…”
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Biased holoenzyme assembly of protein phosphatase 2A (PP2A): From cancer to small molecules by Haanen, Terrance J., O'Connor, Caitlin M., Narla, Goutham

“…Protein phosphatase 2A (PP2A) is a family of serine threonine phosphatases responsible for regulating protein phosphorylation, thus opposing the activity of…”
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The Highly Recurrent PP2A Aα-Subunit Mutation P179R Alters Protein Structure and Impairs PP2A Enzyme Function to Promote Endometrial Tumorigenesis by Taylor, Sarah E, O'Connor, Caitlin M, Wang, Zhizhi, Shen, Guobo, Song, Haichi, Leonard, Daniel, Sangodkar, Jaya, LaVasseur, Corinne, Avril, Stefanie, Waggoner, Steven, Zanotti, Kristine, Armstrong, Amy J, Nagel, Christa, Resnick, Kimberly, Singh, Sareena, Jackson, Mark W, Xu, Wenqing, Haider, Shozeb, DiFeo, Analisa, Narla, Goutham

“…Somatic mutation of the protein phosphatase 2A (PP2A) Aα-subunit gene is highly prevalent in high-grade endometrial carcinoma. The structural, molecular, and…”
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PP2A modulation overcomes multidrug resistance in chronic lymphocytic leukemia via mPTP-dependent apoptosis by Jayappa, Kallesh D, Tran, Brian, Gordon, Vicki L, Morris, Christopher, Saha, Shekhar, Farrington, Caroline C, O'Connor, Caitlin M, Zawacki, Kaitlin P, Isaac, Krista M, Kester, Mark, Bender, Timothy P, Williams, Michael E, Portell, Craig A, Weber, Michael J, Narla, Goutham

“…Targeted therapies such as venetoclax (VEN) (Bcl-2 inhibitor) have revolutionized the treatment of chronic lymphocytic leukemia (CLL). We previously reported…”
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Integrated stress response plasticity governs normal cell adaptation to chronic stress via the PP2A-TFE3-ATF4 pathway by A Avelar, Rita, Gupta, Riya, Carvette, Grace, da Veiga Leprevost, Felipe, Jasti, Medhasri, Colina, Jose, Teitel, Jessica, Nesvizhskii, Alexey I, O'Connor, Caitlin M, Hatzoglou, Maria, Shenolikar, Shirish, Arvan, Peter, Narla, Goutham, DiFeo, Analisa

“…The integrated stress response (ISR) regulates cell fate during conditions of stress by leveraging the cell's capacity to endure sustainable and efficient…”
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Small-Molecule-Mediated Stabilization of PP2A Modulates the Homologous Recombination Pathway and Potentiates DNA Damage-Induced Cell Death by Avelar, Rita A, Armstrong, Amy J, Carvette, Gracie, Gupta, Riya, Puleo, Noah, Colina, Jose A, Joseph, Peronne, Sobeck, Alexander M, O'Connor, Caitlin M, Raines, Brynne, Gandhi, Agharnan, Dziubinski, Michele L, Ma, Daniel S, Resnick, Kimberly, Singh, Sareena, Zanotti, Kristine, Nagel, Christa, Waggoner, Steven, Thomas, Daffyd G, Skala, Stephanie L, Zhang, Junran, Narla, Goutham, DiFeo, Analisa

“…High-grade serous carcinoma (HGSC) is the most common and lethal ovarian cancer subtype. PARP inhibitors (PARPi) have become the mainstay of HGSC-targeted…”
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Targeting Ribonucleotide Reductase Induces Synthetic Lethality in PP2A-Deficient Uterine Serous Carcinoma by O'Connor, Caitlin M, Taylor, Sarah E, Miller, Kathryn M, Hurst, Lauren, Haanen, Terrance J, Suhan, Tahra K, Zawacki, Kaitlin P, Noto, Fallon K, Trako, Jonida, Mohan, Arathi, Sangodkar, Jaya, Zamarin, Dmitriy, DiFeo, Analisa, Narla, Goutham

“…Uterine serous carcinoma (USC) is a highly aggressive endometrial cancer subtype with limited therapeutic options and a lack of targeted therapies. While…”
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Symptoms Improve After a Yoga Program Designed for PTSD in a Randomized Controlled Trial With Veterans and Civilians by Davis, Louanne W, Schmid, Arlene A, Daggy, Joanne K, Yang, Ziyi, O'Connor, Caitlin E, Schalk, Nancy, Do, Ai-Nghia L, Maric, Danka, Lazarick, Donna, Knock, Heidi

“…Objective: Although yoga shows promise as a treatment for posttraumatic stress disorder (PTSD), there are few randomized controlled trials that demonstrate…”
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Loss of LCMT1 and biased protein phosphatase 2A heterotrimerization drive prostate cancer progression and therapy resistance by Rasool, Reyaz ur, O’Connor, Caitlin M., Das, Chandan Kanta, Alhusayan, Mohammed, Verma, Brijesh Kumar, Islam, Sehbanul, Frohner, Ingrid E., Deng, Qu, Mitchell-Velasquez, Erick, Sangodkar, Jaya, Ahmed, Aqila, Linauer, Sarah, Mudrak, Ingrid, Rainey, Jessica, Zawacki, Kaitlin P., Suhan, Tahra K., Callahan, Catherine G., Rebernick, Ryan, Natesan, Ramakrishnan, Siddiqui, Javed, Sauter, Guido, Thomas, Dafydd, Wang, Shaomeng, Taylor, Derek J., Simon, Ronald, Cieslik, Marcin, Chinnaiyan, Arul M., Busino, Luca, Ogris, Egon, Narla, Goutham, Asangani, Irfan A.

“…Loss of the tumor suppressive activity of the protein phosphatase 2A (PP2A) is associated with cancer, but the underlying molecular mechanisms are unclear…”
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Effects of Two Group Prenatal Care Interventions on Mental Health: An RCT by Gennaro, Susan, Melnyk, Bernadette Mazurek, Szalacha, Laura A., Gibeau, Anne M., Hoying, Jacqueline, O'Connor, Caitlin M., Cooper, Andrea R., Aviles, Melanie M.

“…Perinatal depression and anxiety cost the U.S. health system $102 million annually and result in adverse health outcomes. Research supports that cognitive…”
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A generic approach to construct pseudo components for oil weathering models by Geng, Xiaolong, Barker, Christopher H., MacFadyen, Amy, Boufadel, Michel C., Thrift-Viveros, Dalina L., Jones, Robert K., O’Connor, Caitlin, Lee, Kenneth

“…Oil weathering models are essential for predicting the behavior of spilled oil in the environment. Most models use a “Pseudo Component” (PC) approach to…”
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Mutant PP2A Induces IGFBP2 Secretion to Promote Development of High-Grade Uterine Cancer by Haanen, Terrance J., Boock, Sophie, Callahan, Catherine G., Peris, Irene, Zawacki, Kaitlin P., Raines, Brynne, Nino, Charles A., Tran, Brian, Harold, Alexis, Hodges Onishi, Gabrielle, Hinderman, Matthew, Dowdican, Amanda, Huang, Wei, Taylor, Derek J., Taylor, Sarah E., Jackson, Mark W., DiFeo, Analisa, O'Connor, Caitlin M., Narla, Goutham

“…Abstract Uterine serous carcinoma (USC) and uterine carcinosarcoma (UCS) tumors are uniquely aggressive, suggesting that the primary tumor is intrinsically…”
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Structure-Based Design of Selective Fat Mass and Obesity Associated Protein (FTO) Inhibitors by Shishodia, Shifali, Demetriades, Marina, Zhang, Dong, Tam, Nok Yin, Maheswaran, Pratheesh, Clunie-O’Connor, Caitlin, Tumber, Anthony, Leung, Ivanhoe K. H, Ng, Yi Min, Leissing, Thomas M, El-Sagheer, Afaf H, Salah, Eidarus, Brown, Tom, Aik, Wei Shen, McDonough, Michael A, Schofield, Christopher J

“…FTO catalyzes the Fe­(II) and 2-oxoglutarate (2OG)-dependent modification of nucleic acids, including the demethylation of N 6-methyladenosine (m6A) in mRNA…”
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Protein phosphatase 2A Aα regulates Aβ protein expression and stability by O'Connor, Caitlin M., Hoffa, Matthew T., Taylor, Sarah E., Avelar, Rita A., Narla, Goutham

“…Protein phosphatase 2A (PP2A) represses many oncogenic signaling pathways and is an important tumor suppressor. PP2A comprises three distinct subunits and…”
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The SRG rat, a Sprague-Dawley Rag2/Il2rg double-knockout validated for human tumor oncology studies by Noto, Fallon K, Sangodkar, Jaya, Adedeji, Bisoye Towobola, Moody, Sam, McClain, Christopher B, Tong, Ming, Ostertag, Eric, Crawford, Jack, Gao, Xiaohua, Hurst, Lauren, O'Connor, Caitlin M, Hanson, Erika N, Izadmehr, Sudeh, Tohmé, Rita, Narla, Jyothsna, LeSueur, Kristin, Bhattacharya, Kajari, Rupani, Amit, Tayeh, Marwan K, Innis, Jeffrey W, Galsky, Matthew D, Evers, B Mark, DiFeo, Analisa, Narla, Goutham, Jamling, Tseten Y

“…We have created the immunodeficient SRG rat, a Sprague-Dawley Rag2/Il2rg double knockout that lacks mature B cells, T cells, and circulating NK cells. This…”
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Comparison of transversus abdominis plane blocks with liposomal bupivacaine versus ropivacaine in open total abdominal hysterectomy by Alexander, John C., Sunna, Mary, Goldenmerry, YPaul, Mootz, Allison, O'Connor, Caitlin, Ringqvist, Jenny, Bunker, Matthew, Joshi, Girish P., Gasanova, Irina

“…Regional anesthesia is frequently employed in efforts to improve postoperative analgesia and reduce opioid requirements following abdominal surgery. The…”
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Testing the effectiveness of 3D film for laboratory-based studies of emotion by Bride, Daniel L, Crowell, Sheila E, Baucom, Brian R, Kaufman, Erin A, O'Connor, Caitlin G, Skidmore, Chloe R, Yaptangco, Mona

“…Research in psychology and affective neuroscience often relies on film as a standardized and reliable method for evoking emotion. However, clip validation is…”
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Shaping the future of kidney genetics in Australia: proceedings from the KidGen policy implementation workshop 2023 by Mallawaarachchi, Amali, Biros, Erik, Harris, Trudie, Bennetts, Bruce, Boughtwood, Tiffany, Elliott, Justine, Fowles, Lindsay, Gardos, Robert, Garza, Denisse, Goranitis, Ilias, Haas, Matilda, Huntley, Vanessa, Jefferis, Julia, Kassahn, Karin, Leaver, Anna, Lundie, Ben, Lunke, Sebastian, O'Connor, Caitlin, Pratt, Greg, Quinlan, Catherine, Shearman, Dianne, Soraru, Jacqueline, Sundaram, Madhivanan, Tchan, Michel, Valente, Giulia, White, Julie, Wilkins, Ella, Alexander, Steve I, Amir, Noa, Best, Stephanie, Gul, Hossai, Jayasinghe, Kushani, McCarthy, Hugh, Patel, Chirag, Stark, Zornitza, Mallett, Andrew J

“…The KidGen Collaborative's Policy Implementation Workshop 2023 celebrated the 10th anniversary of Australia's first kidney genetics clinic in Brisbane. This…”
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Therapeutic targeting of PP2A by O’Connor, Caitlin M., Perl, Abbey, Leonard, Daniel, Sangodkar, Jaya, Narla, Goutham

“…Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase that regulates many cellular processes. Given the central role of PP2A in regulating…”
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