Search Results - "O’Connell, Kevin"

Genetic contributions to bipolar disorder: current status and future directions by O'Connell, Kevin S, Coombes, Brandon J

“…Bipolar disorder (BD) is a highly heritable mental disorder and is estimated to affect about 50 million people worldwide. Our understanding of the genetic…”
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Centrosomes: An acentriolar MTOC at the ciliary base by O’Connell, Kevin F.

“…Centrioles are microtubule-based organelles that are embedded within pericentriolar material (PCM). Together, they comprise the centrosome, a…”
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The kinase ZYG-1 phosphorylates the cartwheel protein SAS-5 to drive centriole assembly in C. elegans by Sankaralingam, Prabhu, Wang, Shaohe, Liu, Yan, Oegema, Karen F, O’Connell, Kevin F

“…Centrioles organize centrosomes, the cell’s primary microtubule-organizing centers (MTOCs). Centrioles double in number each cell cycle, and mis-regulation of…”
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Cryopreservation of C. elegans and Other Nematodes with Dimethyl Sulfoxide and Trehalose by O'Connell, Kevin F

“…One of the key attributes that has contributed to the popularity of Caenorhabditis elegans as a model system is its ability to survive freezing. By preserving…”
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Shared genetic architecture between schizophrenia and subcortical brain volumes implicates early neurodevelopmental processes and brain development in childhood by Cheng, Weiqiu, van der Meer, Dennis, Parker, Nadine, Hindley, Guy, O’Connell, Kevin S., Wang, Yunpeng, Shadrin, Alexey A., Alnæs, Dag, Bahrami, Shahram, Lin, Aihua, Karadag, Naz, Holen, Børge, Fernandez-Cabello, Sara, Fan, Chun-Chieh, Dale, Anders M., Djurovic, Srdjan, Westlye, Lars T., Frei, Oleksandr, Smeland, Olav B., Andreassen, Ole A.

“…Patients with schizophrenia have consistently shown brain volumetric abnormalities, implicating both etiological and pathological processes. However, the…”
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Genetic Association Between Schizophrenia and Cortical Brain Surface Area and Thickness by Cheng, Weiqiu, Frei, Oleksandr, van der Meer, Dennis, Wang, Yunpeng, O'Connell, Kevin S, Chu, Yunhan, Bahrami, Shahram, Shadrin, Alexey A, Alnæs, Dag, Hindley, Guy F L, Lin, Aihua, Karadag, Naz, Fan, Chun-Chieh, Westlye, Lars T, Kaufmann, Tobias, Molden, Espen, Dale, Anders M, Djurovic, Srdjan, Smeland, Olav B, Andreassen, Ole A

“…Schizophrenia is a complex heritable disorder associated with many genetic variants, each with a small effect. While cortical differences between patients with…”
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Genome-wide analysis reveals extensive genetic overlap between schizophrenia, bipolar disorder, and intelligence by Smeland, Olav B, Bahrami, Shahram, Frei, Oleksandr, Shadrin, Alexey, O’Connell, Kevin, Savage, Jeanne, Watanabe, Kyoko, Krull, Florian, Bettella, Francesco, Steen, Nils Eiel, Ueland, Torill, Posthuma, Danielle, Djurovic, Srdjan, Dale, Anders M, Andreassen, Ole A

“…Schizophrenia (SCZ) and bipolar disorder (BD) are severe mental disorders associated with cognitive impairment, which is considered a major determinant of…”
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Limiting Amounts of Centrosome Material Set Centrosome Size in C. elegans Embryos by Decker, Markus, Jaensch, Steffen, Pozniakovsky, Andrei, Zinke, Andrea, O'Connell, Kevin F., Zachariae, Wolfgang, Myers, Eugene, Hyman, Anthony A.

“…The ways in which cells set the size of intracellular structures is an important but largely unsolved problem [1]. Early embryonic divisions pose special…”
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Genome-wide Association Analysis of Parkinson’s Disease and Schizophrenia Reveals Shared Genetic Architecture and Identifies Novel Risk Loci by Smeland, Olav B., Shadrin, Alexey, Bahrami, Shahram, Broce, Iris, Tesli, Martin, Frei, Oleksandr, Wirgenes, Katrine V., O’Connell, Kevin S., Krull, Florian, Bettella, Francesco, Steen, Nils Eiel, Sugrue, Leo, Wang, Yunpeng, Svenningsson, Per, Sharma, Manu, Pihlstrøm, Lasse, Toft, Mathias, O’Donovan, Michael, Djurovic, Srdjan, Desikan, Rahul, Dale, Anders M., Andreassen, Ole A.

“…Parkinson’s disease (PD) and schizophrenia (SCZ) are heritable brain disorders that involve dysregulation of the dopaminergic system. Epidemiological studies…”
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The chromatin remodeling protein CHD-1 and the EFL-1/DPL-1 transcription factor cooperatively down regulate CDK-2 to control SAS-6 levels and centriole number by Iyer, Jyoti, Gentry, Lindsey K, Bergwell, Mary, Smith, Amy, Guagliardo, Sarah, Kropp, Peter A, Sankaralingam, Prabhu, Liu, Yan, Spooner, Eric, Bowerman, Bruce, O'Connell, Kevin F

“…Centrioles are submicron-scale, barrel-shaped organelles typically found in pairs, and play important roles in ciliogenesis and bipolar spindle assembly. In…”
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Charting the Landscape of Genetic Overlap Between Mental Disorders and Related Traits Beyond Genetic Correlation by Hindley, Guy, Frei, Oleksandr, Shadrin, Alexey A., Cheng, Weiqiu, O’Connell, Kevin S., Icick, Romain, Parker, Nadine, Bahrami, Shahram, Karadag, Naz, Roelfs, Daniel, Holen, Børge, Lin, Aihua, Fan, Chun C., Djurovic, Srdjan, Dale, Anders M., Smeland, Olav B., Andreassen, Ole A.

“…Objective:Mental disorders are heritable and polygenic, and genome-wide genetic correlations (rg) have indicated widespread shared genetic risk across multiple…”
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Genetic Overlap between Global Cortical Brain Structure, C-Reactive Protein, and White Blood Cell Counts by Parker, Nadine, Cheng, Weiqiu, Hindley, Guy F.L., O’Connell, Kevin S., Karthikeyan, Sandeep, Holen, Børge, Shadrin, Alexey A., Rahman, Zillur, Karadag, Naz, Bahrami, Shahram, Lin, Aihua, Steen, Nils Eiel, Ueland, Thor, Aukrust, Pål, Djurovic, Srdjan, Dale, Anders M., Smeland, Olav B., Frei, Oleksandr, Andreassen, Ole A.

“…For many brain disorders, a subset of patients jointly exhibit alterations in cortical brain structure and elevated levels of circulating immune markers. This…”
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Genomic Stratification of Clozapine Prescription Patterns Using Schizophrenia Polygenic Scores by Kappel, Djenifer B., Legge, Sophie E., Hubbard, Leon, Willcocks, Isabella R., O’Connell, Kevin S., Smith, Robert L., Molden, Espen, Andreassen, Ole A., King, Adrian, Jansen, John, Helthuis, Marinka, Owen, Michael J., O’Donovan, Michael C., Walters, James T.R., Pardiñas, Antonio F.

“…Treatment-resistant schizophrenia affects approximately 30% of individuals with the disorder. Clozapine is the medication of choice in treatment-resistant…”
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Identification of genetic overlap and novel risk loci for attention-deficit/hyperactivity disorder and bipolar disorder by O’Connell, Kevin S., Shadrin, Alexey, Bahrami, Shahram, Smeland, Olav B., Bettella, Francesco, Frei, Oleksandr, Krull, Florian, Askeland, Ragna B., Walters, G. Bragi, Davíðsdóttir, Katrín, Haraldsdóttir, Gyða S., Guðmundsson, Ólafur Ó., Stefánsson, Hreinn, Fan, Chun C., Steen, Nils Eiel, Reichborn-Kjennerud, Ted, Dale, Anders M., Stefánsson, Kári, Djurovic, Srdjan, Andreassen, Ole A.

“…Differential diagnosis between childhood onset attention-deficit/hyperactivity disorder (ADHD) and bipolar disorder (BD) remains a challenge, mainly due to…”
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Associations Between Symptoms of Premenstrual Disorders and Polygenic Liability for Major Psychiatric Disorders by Jaholkowski, Piotr, Shadrin, Alexey A, Jangmo, Andreas, Frei, Evgeniia, Tesfaye, Markos, Hindley, Guy F L, Haram, Marit, Rahman, Zillur, Athanasiu, Lavinia, Bakken, Nora Refsum, Holen, Børge, Fominykh, Vera, Kutrolli, Gleda, Parekh, Pravesh, Parker, Nadine, Rødevand, Linn, Birkenæs, Viktoria, Djurovic, Srdjan, Frei, Oleksandr, O'Connell, Kevin S, Smeland, Olav B, Tesli, Martin, Andreassen, Ole A

“…Premenstrual disorders are heritable, clinically heterogenous, with a range of affective spectrum comorbidities. It is unclear whether genetic predispositions…”
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Intracellular neutralisation of rotavirus by VP6-specific IgG by Caddy, Sarah L, Vaysburd, Marina, Wing, Mark, Foss, Stian, Andersen, Jan Terje, O'Connell, Kevin, Mayes, Keith, Higginson, Katie, Iturriza-Gómara, Miren, Desselberger, Ulrich, James, Leo C

“…Rotavirus is a major cause of gastroenteritis in children, with infection typically inducing high levels of protective antibodies. Antibodies targeting the…”
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Genome-wide Association Analysis of Schizophrenia and Vitamin D Levels Shows Shared Genetic Architecture and Identifies Novel Risk Loci by Jaholkowski, Piotr, Hindley, Guy F L, Shadrin, Alexey A, Tesfaye, Markos, Bahrami, Shahram, Nerhus, Mari, Rahman, Zillur, O’Connell, Kevin S, Holen, Børge, Parker, Nadine, Cheng, Weiqiu, Lin, Aihua, Rødevand, Linn, Karadag, Naz, Frei, Oleksandr, Djurovic, Srdjan, Dale, Anders M, Smeland, Olav B, Andreassen, Ole A

“…Abstract Low vitamin D (vitD) levels have been consistently reported in schizophrenia (SCZ) suggesting a role in the etiopathology. However, little is known…”
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The genetic architecture of schizophrenia, bipolar disorder, obsessive-compulsive disorder and autism spectrum disorder by O'Connell, Kevin S., McGregor, Nathaniel W., Lochner, Christine, Emsley, Robin, Warnich, Louise

“…Considerable evidence suggests that autism spectrum disorders (ASD), schizophrenia (SCZ), bipolar disorder (BD) and obsessive-compulsive disorder (OCD) share a…”
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Systemic Cell Adhesion Molecules in Severe Mental Illness: Potential Role of Intercellular CAM-1 in Linking Peripheral and Neuroinflammation by Sheikh, Mashhood A., O’Connell, Kevin S., Lekva, Tove, Szabo, Attila, Akkouh, Ibrahim A., Osete, Jordi Requena, Agartz, Ingrid, Engh, John A., Andreou, Dimitrios, Boye, Birgitte, Bøen, Erlend, Elvsåshagen, Torbjørn, Hope, Sigrun, Frogner Werner, Maren Caroline, Joa, Inge, Johnsen, Erik, Kroken, Rune A., Lagerberg, Trine Vik, Melle, Ingrid, Drange, Ole Kristian, Morken, Gunnar, Nærland, Terje, Sørensen, Kjetil, Vaaler, Arne E., Weibell, Melissa Authen, Westlye, Lars T., Aukrust, Pål, Djurovic, Srdjan, Steen, Nils Eiel, Andreassen, Ole A., Ueland, Thor

“…Cell adhesion molecules (CAMs) orchestrate leukocyte trafficking and could link peripheral and neuroinflammation in patients with severe mental illness (SMI),…”
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Cross-trait genome-wide association analysis of C-reactive protein level and psychiatric disorders by Hindley, Guy, Drange, Ole Kristian, Lin, Aihua, Kutrolli, Gleda, Shadrin, Alexey A., Parker, Nadine, O’Connell, Kevin S., Rødevand, Linn, Cheng, Weiqiu, Bahrami, Shahram, Karadag, Naz, Holen, Børge, Jaholkowski, Piotr, Woldeyohannes, Markos Tesfaye, Djurovic, Srdjan, Dale, Anders M., Frei, Oleksandr, Ueland, Thor, Smeland, Olav B., Andreassen, Ole A.

“…C-reactive protein (CRP) tends to be elevated in individuals with psychiatric disorders. Recent findings have suggested a protective effect of the genetic…”
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