Search Results - "O’Brien, Thomas P."

The Kilodegree Extremely Little Telescope (KELT): A Small Robotic Telescope for Large‐Area Synoptic Surveys by Pepper, Joshua, Pogge, Richard W., DePoy, D. L., Marshall, J. L., Stanek, K. Z., Stutz, Amelia M., Poindexter, Shawn, Siverd, Robert, O’Brien, Thomas P., Trueblood, Mark, Trueblood, Patricia

“…The Kilodegree Extremely Little Telescope (KELT) project is a survey for planetary transits of bright stars. It consists of a small‐aperture, wide‐field…”
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GC–MS Study of the formation of alkoxysilanes from a sol–gel precursor in a hydrophobic solution: A potential new route to hybrid molecular imprinted polymers by Skrdla, Peter J., Shnayderman, Marianna, Wright, Lisa, O’Brien, Thomas P.

“…Tetramethylorthosilicate (tetramethoxysilane; TMOS), a common sol–gel precursor, is found to undergo spontaneous hydrolysis and condensation reactions in a…”
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Privileged structure based ligands for melanocortin receptors—4,4-Disubstituted piperidine derivatives by Kuklish, Steven L., Backer, Ryan T., Briner, Karin, Doecke, Christopher W., Husain, Saba, Mullaney, Jeffrey T., Ornstein, Paul L., Zgombick, John M., O’Brien, Thomas P., Fisher, Matthew J.

“…Homologation and cyclization back to the chiral methine of compound 3 yields achiral 4,4-disubstituted piperidine privileged structures (e.g., 8a) useful in…”
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Synthesis and structure–activity relationships of novel dipeptides and reduced dipeptides as ligands for melanocortin subtype-4 receptor by Shi, Qing, Ornstein, Paul L., Briner, Karin, Richardson, Timothy I., Arnold, Macklin B., Backer, Ryan T., Buckmaster, Jennifer L., Canada, Emily J., Doecke, Christopher W., Hertel, Larry W., Honigschmidt, Nick, Hsiung, Hansen M., Husain, Saba, Kuklish, Steve L., Martinelli, Michael J., Mullaney, Jeffrey T., O’Brien, Thomas P., Reinhard, Matt R., Rothhaar, Roger, Shah, Jikesh, Wu, Zhipei, Xie, Chaoyu, Zgombick, John M., Fisher, Matthew J.

“…The synthesis and SAR studies on the N-terminal residue of the ‘address element’ are reported. A series of benzylic piperazines (e.g., 4 and 5) attached to an…”
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Privileged structure based ligands for melanocortin-4 receptors—Aliphatic piperazine derivatives by Briner, Karin, Collado, Iván, Fisher, Matthew J., García-Paredes, Cristina, Husain, Saba, Kuklish, Steven L., Mateo, Ana I., O’Brien, Thomas P., Ornstein, Paul L., Zgombick, John, de Frutos, Óscar

“…Different substituted cyclic aliphatic piperazines provide useful privileged structures for the construction of ligands with affinity for melanocortin 4…”
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Potent and selective MC-4 receptor agonists based on a novel disulfide scaffold by Yan, Liang Z., Flora, David, Edwards, Patrick, Smiley, David L., Emmerson, Paul J., Hsiung, Hansen M., Gadski, Robert, Hertel, JeAnne, Heiman, Mark L., Husain, Saba, O’Brien, Thomas P., Kahl, Steven D., Zhang, Lianshan, DiMarchi, Richard D., Mayer, John P.

“…Extensive structure–activity relationship studies utilizing a β-MSH-derived cyclic nonapeptide, Ac-Tyr-Arg-[Cys-Glu-His- d-Phe-Arg-Trp-Cys]-NH 2 ( 3), led to…”
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New Pulsatile Hydrostatic Pressure Bioreactor for Vascular Tissue-engineered Constructs by Shaikh, Faisal M., O'Brien, Thomas P., Callanan, Anthony, Kavanagh, Eamon G., Burke, Paul E., Grace, Pierce A., McGloughlin, Timothy M.

“…Mechanical conditioning represents a potential means to enhance the biochemical and biomechanical properties of tissue‐engineered cell constructs. Bioreactors…”
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Interaction Between Synesthetically Corresponding Dimensions by Melara, Robert D, O'Brien, Thomas P

“…This article presents findings of cross-sensory dimensional interaction for the visual dimension of vertical position and the auditory dimension of pitch…”
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A Balanced Approach for Corrections Policy Needed by O'Brien, Thomas P, Jones, Derek J

“…O'Brien and Jones comment negatively on Haney and Zimbardo's treatment of the past 25 years of corrections policy, citing that it suffers from politicization…”
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Synthesis and Structure−Activity Relationships of Novel Arylpiperazines as Potent and Selective Agonists of the Melanocortin Subtype-4 Receptor by Richardson, Timothy I, Ornstein, Paul L, Briner, Karin, Fisher, Matthew J, Backer, Ryan T, Biggers, C. Kelly, Clay, Michael P, Emmerson, Paul J, Hertel, Larry W, Hsiung, Hansen M, Husain, Saba, Kahl, Steven D, Lee, Jonathan A, Lindstrom, Terry D, Martinelli, Michael J, Mayer, John P, Mullaney, Jeffery T, O'Brien, Thomas P, Pawlak, Joseph M, Revell, Kevin D, Shah, Jikesh, Zgombick, John M, Herr, R. Jason, Melekhov, Alex, Sampson, Peter B, King, Chi-Hsin R

“…The melanocortin receptors have been implicated as potential targets for a number of important therapeutic indications, including inflammation, sexual…”
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Evaluation of endotoxin retention by adsorptive-based filtration media by O'Brien, Thomas P, Conway, Robert, Chen, Hsiao-Lin, Buckland, Kim

“…Control of endotoxin contamination is an important issue in pharmaceutical and bioprocess manufacturing. Endotoxins can contaminate process intermediates used…”
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Discovery of a β-MSH-Derived MC-4R Selective Agonist by Mayer, John P, Hsiung, Hansen M, Flora, David B, Edwards, Patrick, Smith, Dennis P, Zhang, Xing-Yue, Gadski, Robert A, Heiman, Mark L, Hertel, JeAnne L, Emmerson, Paul J, Husain, Saba, O'Brien, Thomas P, Kahl, Steven D, Smiley, David L, Zhang, Lianshan, DiMarchi, Richard D, Yan, Liang Zeng

“…A series of novel, disulfide-constrained human β-melanocyte stimulating hormone (β-MSH)-derived peptides were optimized for in vitro melanocortin-4 receptor…”
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Rational Design of an Imprinted Polymer: Maximizing Selectivity by Optimizing the Monomer-Template Ratio for a Cinchonidine MIP, Prior to Polymerization, Using Microcalorimetry by Fish, William P., Ferreira, James, Sheardy, Richard D., Snow, Nicholas H., O'Brien, Thomas P.

“…Molecular imprinting, a technique that allows for preparation of adsorbents with sites tailored for recognition of a particular molecule, continues to grow…”
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A Retention Model for Polar Selectivity in Reversed Phase Chromatography as a Function of Mobile Phase Organic Modifier Type by Zhuang, Ping, Thompson, Richard A., O'Brien, Thomas P.

“…Elucidation of solute retention as a function of the mobile phase modifier type under reversed phase conditions was investigated. The retention of steroid…”
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Increasing the Quantity and Quality of School Leadership Candidates Through Formation Experiences by Busch, Joseph R., O'Brien, Thomas P., Spangler, William D.

“…After a review of the relevant school leadership and business management literatures, a leadership program was established based on the formation component of…”
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Comparison of cerebrovascular effects of intravenous cocaine injection in fetal, newborn, and adult sheep by Robinson, R, Iida, H, O'Brien, T P, Pane, M A, Traystman, R J, Gleason, C A

“…Cocaine may cause stroke, intracranial hemorrhage, seizures, and neurobehavioral abnormalities in fetuses, newborns, and adults, and there could be…”
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MECHANISTIC ASPECTS OF CHIRAL DISCRIMINATION ON A MOLECULAR IMPRINTED POLYMER PHASE by O'Brien, Thomas P., Snow, Nicholas H., Grinberg, Nelu, Crocker, Louis

“…The mechanism of chiral selectivity of a difunctional polymer imprinted with dansyl-L-phenylalanine was investigated using the polymer as an HPLC stationary…”
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Propranolol blocks cocaine-induced cerebral vasodilation in newborn sheep by O'Brien, Thomas P, Pane, Maria A, Traystman, Richard J, Gleason, Christine A

“…OBJECTIVEThe objective of this study was to test the hypothesis that cocaine-induced cerebral vasodilation in newborn sheep is mediated via beta-adrenergic…”
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Social Science and the Crafting of Legislation by O'Brien, Thomas P, Cox, Philip

“…O'Brien and Cox emphasize the need for social scientists to avoid dressing up their ideological agendas under the category of science. They are quick to point…”
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Determination of bis(tributyltin) oxide by GC–MS with on-line hydride derivatization: application to drug substance analysis by O'Brien, Thomas P, Dowling, Thomas M, Moeder, Charles W, Bicker, Gary R

“…We report the determination of residual bis(tributyltin) oxide in a drug substance by GC–MS after extraction and on-line conversion to tributyltin hydride. Gas…”
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