Search Results - "O’Brien, Richard J"

Amyloid precursor protein processing and Alzheimer's disease by O'Brien, Richard J, Wong, Philip C

“…Alzheimer's disease (AD), the leading cause of dementia worldwide, is characterized by the accumulation of the β-amyloid peptide (Aβ) within the brain along…”
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Long-term cortisol measures predict Alzheimer disease risk by Ennis, Gilda E, An, Yang, Resnick, Susan M, Ferrucci, Luigi, OʼBrien, Richard J, Moffat, Scott D

“…OBJECTIVE:To examine whether long-term measures of cortisol predict Alzheimer disease (AD) risk. METHOD:We used a prospective longitudinal design to examine…”
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Personality and risk of Alzheimer's disease: New data and meta-analysis by Terracciano, Antonio, Sutin, Angelina R, An, Yang, O'Brien, Richard J, Ferrucci, Luigi, Zonderman, Alan B, Resnick, Susan M

“…Abstract Background We examine whether broad factors and specific facets of personality are associated with increased risk of incident Alzheimer's disease (AD)…”
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Magnetic resonance imaging of mouse brain networks plasticity following motor learning by Badea, Alexandra, Ng, Kwan L, Anderson, Robert J, Zhang, Jiangyang, Miller, Michael I, O'Brien, Richard J

“…We do not have a full understanding of the mechanisms underlying plasticity in the human brain. Mouse models have well controlled environments and genetics,…”
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Changes in brain function occur years before the onset of cognitive impairment by Beason-Held, Lori L, Goh, Joshua O, An, Yang, Kraut, Michael A, O'Brien, Richard J, Ferrucci, Luigi, Resnick, Susan M

“…To develop targeted intervention strategies for the treatment of Alzheimer's disease, we first need to identify early markers of brain changes that occur…”
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Exploratory Assessment of Proteomic Network Changes in Cerebrospinal Fluid of Mild Cognitive Impairment Patients: A Pilot Study by Kamalian, Aida, Ho, Sara G, Patel, Megha, Lewis, Alexandria, Bakker, Arnold, Albert, Marilyn, O'Brien, Richard J, Moghekar, Abhay, Lutz, Michael W

“…(1) Background: Despite the existence of well-established, CSF-based biomarkers such as amyloid-β and phosphorylated-tau, the pathways involved in the…”
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Identifying vulnerable brain networks associated with Alzheimer’s disease risk by Mahzarnia, Ali, Stout, Jacques A, Anderson, Robert J, Moon, Hae Sol, Yar Han, Zay, Beck, Kate, Browndyke, Jeffrey N, Dunson, David B, Johnson, Kim G, O’Brien, Richard J, Badea, Alexandra

“…Abstract The selective vulnerability of brain networks in individuals at risk for Alzheimer’s disease (AD) may help differentiate pathological from normal…”
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Moxifloxacin-containing Regimen Greatly Reduces Time to Culture Conversion in Murine Tuberculosis by Nuermberger, Eric L, Yoshimatsu, Tetsuyuki, Tyagi, Sandeep, O'Brien, Richard J, Vernon, Andrew N, Chaisson, Richard E, Bishai, William R, Grosset, Jacques H

“…Tuberculosis continues to be a major cause of morbidity and mortality in the world. The expansion of tuberculosis control programs has been limited by the…”
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Optimizing Diffusion Imaging Protocols for Structural Connectomics in Mouse Models of Neurological Conditions by Anderson, Robert J, Long, Christopher M, Calabrese, Evan D, Robertson, Scott H, Johnson, G Allan, Cofer, Gary P, O'Brien, Richard J, Badea, Alexandra

“…Network approaches provide sensitive biomarkers for neurological conditions, such as Alzheimer's disease (AD). Mouse models can help advance our understanding…”
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The need for new drugs against tuberculosis : Obstacles, opportunities, and next steps by O'BRIEN, Richard J, NUNN, Paul P

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Synaptic clustering of AMPA receptors by the extracellular immediate-early gene product Narp by O'Brien, R J, Xu, D, Petralia, R S, Steward, O, Huganir, R L, Worley, P

“…Narp (neuronal activity-regulated pentraxin) is a secreted immediate-early gene (IEG) regulated by synaptic activity in brain. In this study, we demonstrate…”
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children by Lewinsohn, David M., Leonard, Michael K., LoBue, Philip A., Cohn, David L., Daley, Charles L., Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A., Loeffler, Ann M., Mazurek, Gerald H., O'Brien, Richard J., Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M., Sterling, Timothy R., Warshauer, David M., Woods, Gail L.

“…Background. Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical…”
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New drugs for tuberculosis: current status and future prospects by O'Brien, Richard J, Spigelman, Mel

“…This article reviews two classes of compounds that have advanced into phase II and III clinical trials, long-acting rifamycins and fluoroquinolones, and a…”
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Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit by Roche, Katherine W, O'Brien, Richard J, Mammen, Andrew L, Bernhardt, Jeffrey, Huganir, Richard L

“…We have characterized the phosphorylation of the glutamate receptor subunit GluR1, using biochemical and electrophysiological techniques. GluR1 is…”
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Official American Thoracic Society/Infectious Diseases Society of America/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children by Lewinsohn, David M, Leonard, Michael K, LoBue, Philip A, Cohn, David L, Daley, Charles L, Desmond, Ed, Keane, Joseph, Lewinsohn, Deborah A, Loeffler, Ann M, Mazurek, Gerald H, O'Brien, Richard J, Pai, Madhukar, Richeldi, Luca, Salfinger, Max, Shinnick, Thomas M, Sterling, Timothy R, Warshauer, David M, Woods, Gail L

“…Individuals infected with Mycobacterium tuberculosis (Mtb) may develop symptoms and signs of disease (tuberculosis disease) or may have no clinical evidence of…”
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Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model by Ng, Kwan L, Gibson, Ellen M, Hubbard, Robert, Yang, Juemin, Caffo, Brian, O’Brien, Richard J, Krakauer, John W, Zeiler, Steven R

“…BACKGROUND AND PURPOSE—Data from both humans and animal models suggest that most recovery from motor impairment after stroke occurs in a sensitive period that…”
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Molecular mechanisms of glutamate receptor clustering at excitatory synapses by O'Brien, Richard J, Lau, Lit-Fui, Huganir, Richard L

“…The targeting of AMPA- and NMDA-type glutamate receptors to synapses in the central nervous system is essential for efficient excitatory synaptic transmission…”
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Redistribution and Stabilization of Cell Surface Glutamate Receptors during Synapse Formation by Mammen, Andrew L, Huganir, Richard L, O'Brien, Richard J

“…Although the regulation of neurotransmitter receptors during synaptogenesis has been studied extensively at the neuromuscular junction, little is known about…”
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Splice Variant-Specific Interaction of the NMDA Receptor Subunit NR1 with Neuronal Intermediate Filaments by Ehlers, Michael D, Fung, Eric T, O'Brien, Richard J, Huganir, Richard L

“…NMDA receptors are excitatory neurotransmitter receptors critical for synaptic plasticity and neuronal development in the mammalian brain. These receptors are…”
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Glucose intolerance, insulin resistance, and pathological features of Alzheimer disease in the Baltimore Longitudinal Study of Aging by Thambisetty, Madhav, Jeffrey Metter, E, Yang, An, Dolan, Hillary, Marano, Christopher, Zonderman, Alan B, Troncoso, Juan C, Zhou, Yun, Wong, Dean F, Ferrucci, Luigi, Egan, Josephine, Resnick, Susan M, O'Brien, Richard J

“…Peripheral glucose homeostasis has been implicated in the pathogenesis of Alzheimer disease (AD). The relationship among diabetes mellitus, insulin, and AD is…”
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